Title: Most individuals with treated blood pressures above target receive only one or two antihypertensive drug classes
Authors: Campbell, DJ
McGrady, M
Prior, DL
Coller, JM
Boffa, U
Shiel, L
Liew, D
Wolfe, R
Stewart, S
Reid, CM
Krum, H
Issue Year: 2013
Publisher WILEY-BLACKWELL
Series INTERNAL MEDICINE JOURNAL: 43(2): 137-143
Abstract Background A significant proportion of individuals taking antihypertensive therapies fail to achieve blood pressures <140/90mmHg. In order to develop strategies for improved treatment of blood pressure, we examined the association of blood pressure control with antihypertensive therapies and clinical and lifestyle factors in a cohort of adults at increased cardiovascular risk. Methods A cross-sectional study of 3994 adults from Melbourne and Shepparton, Australia enrolled in the SCReening Evaluation of the Evolution of New Heart Failure (SCREEN-HF) study. Inclusion criteria were age 60 years with one or more of self-reported ischaemic or other heart disease, atrial fibrillation, cerebrovascular disease, renal impairment or treatment for hypertension or diabetes for 2 years. Exclusion criteria were known heart failure or cardiac abnormality on echocardiography or other imaging. The main outcome measures were the proportion of participants receiving antihypertensive therapy with blood pressures 140/90mmHg and the association of blood pressure control with antihypertensive therapies and clinical and lifestyle factors. Results Of 3623 participants (1975 men and 1648 women) receiving antihypertensive therapy, 1867 (52%) had blood pressures 140/90mmHg. Of these 1867 participants, 1483 (79%) were receiving only one or two antihypertensive drug classes. Blood pressures 140/90mmHg were associated with increased age, male sex, waist circumference and log amino-terminal-pro-B-type natriuretic peptide levels. Conclusions Most individuals with treated blood pressures above target receive only one or two antihypertensive drug classes. Prescribing additional antihypertensive drug classes and lifestyle modification may improve blood pressure control in this population of individuals at increased cardiovascular risk.
URI: https://publications.svi.edu.au/publications/1732
ISSN 1444-0903
Other Identifiers 10.1111/j.1445-5994.2012.02927.x
Publication type Article