Title: Crystallisation and preliminary X-ray diffraction analysis of the Fab portion of Alzheimer’s disease immunotherapy Bapineuzumab
Authors:
Issue Year: 2014
Publisher
Series Acta Crystallogr F Struct Biol Commun:
Abstract Bapineuzumab (AAB-001) and its derivative (AAB-003) are humanized versions of the anti-Aβ murine antibody 3D6 and are immunotherapy candidates in Alzheimer's disease. The common Fab fragment of these immunotherapies has been expressed, purified and crystallized in complex with β-amyloid peptides (residues 1-8 and 1-28). Diffraction data at high resolution were acquired from crystals of Fab-Aβ8 (2.0 Å) and Fab-Aβ28 (2.2 Å) complexes at the Australian Synchrotron. Both crystal forms belonged to the primitive orthorhombic space group P21221
URI: https://publications.svi.edu.au/publications/2420
ISSN
Other Identifiers 70(Pt 3):374-7
Publication type Article
Grant ID GNT1021645; GNT1021935
Find it online https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944706/