Title: Remote Control in Formation of 3D Multicellular Assemblies Using Magnetic Forces
Authors: Jafari, J
Han, XL
Palmer, J
Tran, PA
O’Connor, AJ
Issue Year: 2019
Publisher AMER CHEMICAL SOC
Series ACS BIOMATERIALS SCIENCE & ENGINEERING:
Abstract The oxytocinase subfamily of M1 aminopeptidases plays an important role in processing and trimming of peptides for presentation on major histocompatibility (MHC) Class I molecules. Several large-scale genomic studies have identified association of members of this family of enzymes, most notably ERAP1 and ERAP2, with immune-mediated diseases including ankylosing spondylitis, psoriasis and birdshot chorioretinopathy. Much is now known about the genetics of these enzymes and how genetic variants alter their function, but how these variants contribute to disease remains largely unresolved. Here we discuss what is known about their structure and function and highlight some of the knowledge gaps that affect development of drugs targeting these enzymes.
URI: https://publications.svi.edu.au/publications/7861
Other Identifiers 10.1021/acsbiomaterials.9b00297
Publication type Article