| Title: | Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia |
| Authors: | Glaser, SP Lee, EF Trounson, E Bouillet, P Wei, A Fairlie, WD Izon, DJ Zuber, J Rappaport, AR Herold, MJ Alexander, WS Lowe, SW Robb, L Strasser, A |
| Issue Year: | 2012 |
| Publisher | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT |
| Series | GENES & DEVELOPMENT: 26(2): 120-125 |
| Abstract | Acute myeloid leukemia (AML) frequently relapses after initial treatment. Drug resistance in AML has been attributed to high levels of the anti-apoptotic Bcl-2 family members Bcl-x(L) and Mcl-1. Here we report that removal of Mcl-1, but not loss or pharmacological blockade of Bcl-x(L), Bcl-2, or Bcl-w, caused the death of transformed AML and could cure disease in AML-afflicted mice. Enforced expression of selective inhibitors of prosurvival Bcl-2 family members revealed that Mcl-1 is critical for survival of human AML cells. Thus, targeting of Mcl-1 or regulators of its expression may be a useful strategy for the treatment of AML. |
| URI: | https://publications.svi.edu.au/publications/1614 |
| Other Identifiers | 10.1101/gad.182980.111 |
| Publication type | Article |
| Find it online | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273836/ |