Title: Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
Authors: Glaser, SP
Lee, EF
Trounson, E
Bouillet, P
Wei, A
Fairlie, WD
Izon, DJ
Zuber, J
Rappaport, AR
Herold, MJ
Alexander, WS
Lowe, SW
Robb, L
Strasser, A
Issue Year: 2012
Series GENES & DEVELOPMENT: 26(2): 120-125
Abstract Acute myeloid leukemia (AML) frequently relapses after initial treatment. Drug resistance in AML has been attributed to high levels of the anti-apoptotic Bcl-2 family members Bcl-x(L) and Mcl-1. Here we report that removal of Mcl-1, but not loss or pharmacological blockade of Bcl-x(L), Bcl-2, or Bcl-w, caused the death of transformed AML and could cure disease in AML-afflicted mice. Enforced expression of selective inhibitors of prosurvival Bcl-2 family members revealed that Mcl-1 is critical for survival of human AML cells. Thus, targeting of Mcl-1 or regulators of its expression may be a useful strategy for the treatment of AML.
URI: https://publications.svi.edu.au/publications/1614
Other Identifiers 10.1101/gad.182980.111
Publication type Article
Find it online http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273836/