Title: The granulocyte-colony stimulating factor receptor (G-CSFR) interacts with retinoic acid receptors (RARs) in the regulation of myeloid differentiation
Authors: Chee, LCY
Hendy, J
Purton, LE
McArthur, GA
Issue Year: 2013
Publisher FEDERATION AMER SOC EXP BIOL
Series JOURNAL OF LEUKOCYTE BIOLOGY: 93(2): 235-243
Abstract The key roles of RARs and G-CSFR in the regulation of granulopoiesis have been well-documented. In this study, we sought to investigate the interaction between G-CSFR and RARs in myeloid differentiation of adult mice through conditional deletion of RAR alpha or RAR gamma on a G-CSFR-/- background and by pharmacological intervention of WT and G-CSFR-/- mice with a pan-RAR inverse agonist, NRX194310. Our findings show that residual granulopoiesis still persists in mice doubly null for G-CSFR and RAR alpha or RAR gamma, confirming that RARs and G-CSFR are dispensable in maintaining residual granulopoiesis. Moreover, an increase in mature myeloid cells was seen in the conditional RAR gamma(Delta/Delta) mice and WT mice treated with NRX194310, likely mediated through increased G-CSF production. However, with the loss of G-CSFR, this expansion in granulopoiesis was attenuated, supporting the hypothesis that G-CSFR signaling interacts with RARs in the regulation of myeloid differentiation. J. Leukoc. Biol. 93: 235-243; 2013.
URI: https://publications.svi.edu.au/publications/1673
Other Identifiers 10.1189/jlb.1211609
Publication type Article
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