Publications by Researcher: Purton, LE

Year	Title	Author(s)
2011	Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment Blood. 117(21):5631-42	Liddicoat, B Jovic, T Russell, MR Singbrant, S Izon, DJ Purton, LE Sankaran, VG Martin, TJ Sims, NA Walkley, CR
2012	Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche? Blood Cancer Journal	Noll, JE Williams, SA Purton, LE Zannettino, ACW
2012	A Novel Population of Cells Expressing Both Hematopoietic and Mesenchymal Markers Is Present in the Normal Adult Bone Marrow and Is Augmented in a Murine Model of Marrow Fibrosis American Journal Of Pathology	Ohishi, M Ono, W Ono, N Khatri, R Marzia, M Baker, EK Root, SH Wilson, TL Iwamototo, Y Kronenberg, HM Aguila, HL Purton, LE Schipani, E
2013	The granulocyte-colony stimulating factor receptor (G-CSFR) interacts with retinoic acid receptors (RARs) in the regulation of myeloid differentiation Journal Of Leukocyte Biology	Chee, LCY Hendy, J Purton, LE McArthur, GA
2013	ATRA and the specific RAR alpha agonist, NRX195183, have opposing effects on the clonogenicity of pre-leukemic murine AML1-ETO bone marrow cells Leukemia	Chee, LCY Hendy, J Purton, LE McArthur, GA
2013	Deciphering Hematopoietic Stem Cells in Their Niches: A Critical Appraisal of Genetic Models, Lineage Tracing, and Imaging Strategies Cell Stem Cell	Joseph, C Quach, JM Walkley, CR Lane, SW Lo Celso, C Purton, LE
2013	Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA Bone	Mutsaers, AJ Ng, AJM Baker, EK Russell, MR Chalk, AM Wall, M Liddicoat, BJJ Ho, PWM Slavin, JL Goradia, A Martin, TJ Purton, LE Dickins, RA Walkley, CR
2014	Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors British Journal Of Haematology	Dewamitta, SR Joseph, C Purton, LE Walkley, CR
2014	Myeloma plasma cells alter the bone marrow microenvironment by stimulating the proliferation of mesenchymal stromal cells Haematologica	Noll, JE Williams, SA Tong, CM Wang, HS Quach, JM Purton, LE Pilkington, K To, LB Evdokiou, A Gronthos, S Zannettino, ACW
2014	The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis Journal Of Clinical Investigation	Smeets, MF DeLuca, E Wall, M Quach, JM Chalk, AM Deans, AJ Heierhorst, J Purton, LE Izon, DJ Walkley, CR
2015	Src family kinases and their role in hematological malignancies Leukemia & Lymphoma	Ku, M Wall, M MacKinnon, RN Walkley, CR Purton, LE Tam, C Izon, D Campbell, L Cheng, HC Nandurkar, H
2015	The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation Plos Genetics	Ng, AJM Walia, MK Smeets, MF Mutsaers, AJ Sims, NA Purton, LE Walsh, NC Martin, TJ Walkley, CR
2015	EphB4 Expressing Stromal Cells Exhibit an Enhanced Capacity for Hematopoietic Stem Cell Maintenance Stem Cells	Nguyen, TM Arthur, A Panagopoulos, R Paton, S Hayball, JD Zannettino, ACW Purton, LE Matsuo, K Gronthos, S
2015	Ciliary neutrotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure. Sci Rep	King, HA Walkley, CR Jovic, T Smeets, MF White, KE Baker, EK Askmyr, M Maluenda, AC Quach, JM Purton, LE
2015	Myelosuppressive Therapies Significantly Increase ProInflammatory Cytokines and Directly Cause Bone Loss Journal Of Bone And Mineral Research	Quach, JM Askmyr, M Jovic, T Baker, EK Walsh, NC Harrison, SJ Neeson, P Ritchie, D Ebeling, PR Purton, LE
2015	Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure Cell Reports	Askmyr, M White, KE Jovic, T King, HA Quach, JM Maluenda, JC Baker, EK Smeets, MF Walkley, CR Purton, LE
2015	Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma Bone	Baker, EK Taylor, S Gupte, A Chalk, AM Bhattacharya, S Green, AC Martin, TJ Strbenac, D Robinson, MD Purton, LE Walkley, CR
2015	Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure Sci Rep	Askmyr, M White, KE Jovic, T King, HA Quach, JM Maluenda, AC Baker, EK Smeets, MF Walkley, CR Purton, LE
2015	RAR gamma is a negative regulator of osteoclastogenesis J. Steroid Biochem. Mol. Biol.	Green, AC Poulton, IJ Vrahnas, C Hausler, KD Walkley, CR Wu, JY Martin, TJ Gillespie, MT Chandraratna, RAS Quinn, JMW Sims, NA Purton, LE
2016	Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis Exp Hematol	Li, JB Piskol, R Wall, M Lu, J Hartner, JC Sankaran, VG Orkin, SH Liddicoat, BJ Kingsley, PD Palis, J Chalk, AM Seeburg, PH Ramaswami, G Purton, LE Walkley, CR
2016	The role of vitamin A and retinoic acid receptor signaling in post-natal maintenance of bone J. Steroid Biochem. Mol. Biol.	Green, AC Martin, TJ Purton, LE
2016	Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death Oncogene	Bhattacharya, S Chalk, AM Ng, AJM Martin, TJ Zannettino, AC Purton, LE Lu, J Baker, EK Walkley, CR
2016	Retinoic Acid Receptor γ Regulates B and T Lymphopoiesis via Nestin-Expressing Cells in the Bone Marrow and Thymic Microenvironm J Immunol	Nota, C Joseph, C Fletcher, JL Maluenda, AC Green, AC Purton, LE
2016	Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr Mol. Cell. Biol.	Thoms, JAI Knezevic, K Liu, JJ Glaros, EN Thai, T Qiao, Q Campbell, H Packham, D Huang, YZ Papathanasiou, P Tunningley, R Whittle, B Yeung, AWS Chandrakanthan, V Hesson, L Chen, V Wong, JWH Purton, LE Ward, RL Thomas, SR Pimanda, JE
2016	T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments Nature	Hawkins, ED Duarte, D Akinduro, O Khorshed, RA Passaro, D Nowicka, M Straszkowski, L Scott, MK Rothery, S Ruivo, N Foster, K Waibel, M Johnstone, RW Harrison, SJ Westerman, DA Quach, H Gribben, J Robinson, MD Purton, LE Bonnet, D Lo Celso, C
2016	PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells Proc. Natl. Acad. Sci. U. S. A.	Chandrakanthan, V Yeola, A Kwan, JC Oliver, RA Qiao, Q Kang, YC Zarzour, P Beck, D Boelen, L Unnikrishnan, A Villanueva, JE Nunez, AC Knezevic, K Palu, C Nasrallah, R Carnell, M Macmillan, A Whan, R Yu, Y Hardy, P Grey, ST Gladbach, A Delerue, F Ittner, L Mobbs, R Walkley, CR Purton, LE Ward, RL Wong, JWH Hesson, LB Walsh, W Pimanda, JE
2017	Retinoic acid receptor signalling directly regulates osteoblast and adipocyte differentiation from mesenchymal progenitor cells Exp. Cell Res.	Green, AC Kocovski, P Jovic, T Walia, MK Chandraratna, RAS Martin, TJ Baker, EK Purton, LE
2018	Extrinsic Regulation of Hematopoietic Stem Cells and Lymphocytes by Vitamin A Curr. Stem. Cell Rep.	Joseph, C Green, AC Kwang, D Purton, LE
2018	Protagonist or antagonist? The complex roles of retinoids in the regulation of hematopoietic stem cells and their specification from pluripotent stem cells Exp. Hematol.	Grace, CS Mikkola, HKA Dou, DR Calvanese, V Ronn, RE Purton, LE
2018	mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis Sci Rep	Martin, SK Fitter, S El Khawanky, N Grose, RH Walkley, CR Purton, LE Ruegg, MA Hall, MN Gronthos, S Zannettino, ACW
2018	Retinoic Acid Receptor gamma Activity in Mesenchymal Stem Cells Regulates Endochondral Bone, Angiogenesis, and B Lymphopoiesis J. Bone Miner. Res.	Green, AC Rudolph-Stringer, V Straszkowski, L Tjin, G Crimeen-Irwin, B Walia, M Martin, TJ Sims, NA Purton, LE
2018	Srsf2(P95H) initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells Blood	Smeets, MF Tan, SY Xu, JJ Anande, G Unnikrishnan, A Chalk, AM Taylor, SR Pimanda, JE Wall, M Purton, LE Walkley, CR
2018	Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML Cell Stem Cell	Duarte, D Hawkins, ED Akinduro, O Ang, H Filippo, KD Kong, IY Haltalli, M Ruivo, N Straszkowski, L Vervoort, SJ McLean, C Weber, TS Khorshed, R Pirillo, C Wei, A Ramasamy, SK Kusumbe, AP Duffy, K Adams, RH Purton, LE Carlin, LM Celso, CL
2019	The haematopoietic stem cell niche: a new player in cardiovascular disease? Cardiovasc. Res.	Al-Sharea, A Lee, MKS Purton, LE Hawkins, ED Murphy, AJ
2019	Mesenchymal lineage cells and their importance in B lymphocyte niches Bone	Green, AC Rudolph-Stringer, V Chantry, AD Wu, JY Purton, LE
2019	A population of nonneuronal GFR alpha 3-expressing cells in the bone marrow resembles nonmyelinating Schwann cells Cell And Tissue Research	Thai, J Green, AC Stamp, LA Spencer, NJ Purton, LE Ivanusic, J
2019	Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal Exp. Hematol.	Xu, JJ Srneets, MF Tan, SY Wall, M Purton, LE Walkley, CR
2019	Higher Intensity of Cell Surface Glucose-Regulated Protein 78 (csGRP78) Expression Is Seen in Patients with Early Progressive Disease/Mortality in a Cohort of Relapsed, Refractory Multiple Myeloma Patients Treated with Carfilzomib, Thalidomide and Dexamethasone Blood	Ninkovic, S Harrison, S Straszkowski, L Quattrocchi, G Chng, WJ Purton, LE Quach, H
2019	Imaging methods used to study mouse and human HSC niches: Current and emerging technologies Bone	Tjin, G Flores-Figueroa, E Duarte, D Straszkowski, L Scott, M Khorshed, RA Purton, LE Lo Celso, C
2019	Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly Scientific Reports	Ku, M MacKinnon, RN Wall, M Narayan, N Walkley, C Cheng, HC Campbell, LJ Purton, LE Nandurkar, H
2019	All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia Cell Death & Disease	Nguyen, CH Bauer, K Hackl, H Schlerka, A Koller, E Hladik, A Stoiber, D Zuber, J Staber, PB Hoelbl-Kovacic, A Purton, LE Grebien, F Wieser, R
2020	Sugar Rush: Supercharging Blood Cell Specification via the Inflammasome Developmental Cell	Tjin, G Purton, LE
2020	All-transretinoic acid in non-promyelocytic acute myeloid leukemia: driver lesion dependent effects on leukemic stem cells Cell Cycle	Nguyen, CH Grandits, AM Purton, LE Sill, H Wieser, R
2020	Effects of chemotherapy agents used to treat pediatric acute lymphoblastic leukemia patients on bone parameters and longitudinal growth of juvenile mice Experimental Hematology	Straszkowski, L Jovic, T Castillo-Tandazo, W Ritchie, DS Purton, LE
2021	From the niche to malignant hematopoiesis and back: reciprocal interactions between leukemia and the bone marrow microenvironment Jbmr Plus	Soto, CA Lo Celso, C Purton, LE Frisch, BJ
2021	Regulation of murine B lymphopoiesis by stromal cells Immunological Reviews	Kwang, D Tjin, G Purton, LE
2021	Human, mouse, and dog bone marrow show similar mesenchymal stromal cells within a distinctive microenvironment Experimental Hematology	Meza-Leon, B Gratzinger, D Aguilar-Navarro, AG Juarez-Aguilar, FG Rebel, VI Torlakovic, E Purton, LE Dorantes-Acosta, EM Escobar-Sanchez, A Dick, JE Flores-Figueroa, E
2021	The characterization of distinct populations of murine skeletal cells that have different roles in B lymphopoiesis Blood	Green, AC Tjin, G Lee, SC Chalk, AM Straszkowski, L Kwang, D Baker, EK Quach, JM Kimura, T Wu, JY Purton, LE