Publications by Researcher: Purton, LE

2011 Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment
Blood. 117(21):5631-42
Liddicoat, B Jovic, T Russell, MR Singbrant, S Izon, DJ Purton, LE Sankaran, VG Martin, TJ Sims, NA Walkley, CR
2012 Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche?
Blood Cancer Journal
Noll, JE Williams, SA Purton, LE Zannettino, ACW
2012 A Novel Population of Cells Expressing Both Hematopoietic and Mesenchymal Markers Is Present in the Normal Adult Bone Marrow and Is Augmented in a Murine Model of Marrow Fibrosis
American Journal Of Pathology
Ohishi, M Ono, W Ono, N Khatri, R Marzia, M Baker, EK Root, SH Wilson, TL Iwamototo, Y Kronenberg, HM Aguila, HL Purton, LE Schipani, E
2013 The granulocyte-colony stimulating factor receptor (G-CSFR) interacts with retinoic acid receptors (RARs) in the regulation of myeloid differentiation
Journal Of Leukocyte Biology
Chee, LCY Hendy, J Purton, LE McArthur, GA
2013 ATRA and the specific RAR alpha agonist, NRX195183, have opposing effects on the clonogenicity of pre-leukemic murine AML1-ETO bone marrow cells
Chee, LCY Hendy, J Purton, LE McArthur, GA
2013 Deciphering Hematopoietic Stem Cells in Their Niches: A Critical Appraisal of Genetic Models, Lineage Tracing, and Imaging Strategies
Cell Stem Cell
Joseph, C Quach, JM Walkley, CR Lane, SW Lo Celso, C Purton, LE
2013 Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA
Mutsaers, AJ Ng, AJM Baker, EK Russell, MR Chalk, AM Wall, M Liddicoat, BJJ Ho, PWM Slavin, JL Goradia, A Martin, TJ Purton, LE Dickins, RA Walkley, CR
2014 Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors
British Journal Of Haematology
Dewamitta, SR Joseph, C Purton, LE Walkley, CR
2014 Myeloma plasma cells alter the bone marrow microenvironment by stimulating the proliferation of mesenchymal stromal cells
Noll, JE Williams, SA Tong, CM Wang, HS Quach, JM Purton, LE Pilkington, K To, LB Evdokiou, A Gronthos, S Zannettino, ACW
2014 The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis
Journal Of Clinical Investigation
Smeets, MF DeLuca, E Wall, M Quach, JM Chalk, AM Deans, AJ Heierhorst, J Purton, LE Izon, DJ Walkley, CR
2015 Src family kinases and their role in hematological malignancies
Leukemia & Lymphoma
Ku, M Wall, M MacKinnon, RN Walkley, CR Purton, LE Tam, C Izon, D Campbell, L Cheng, HC Nandurkar, H
2015 The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation
Plos Genetics
Ng, AJM Walia, MK Smeets, MF Mutsaers, AJ Sims, NA Purton, LE Walsh, NC Martin, TJ Walkley, CR
2015 EphB4 Expressing Stromal Cells Exhibit an Enhanced Capacity for Hematopoietic Stem Cell Maintenance
Stem Cells
Nguyen, TM Arthur, A Panagopoulos, R Paton, S Hayball, JD Zannettino, ACW Purton, LE Matsuo, K Gronthos, S
2015 Ciliary neutrotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure.
Sci Rep
King, HA Walkley, CR Jovic, T Smeets, MF White, KE Baker, EK Askmyr, M Maluenda, AC Quach, JM Purton, LE
2015 Myelosuppressive Therapies Significantly Increase ProInflammatory Cytokines and Directly Cause Bone Loss
Journal Of Bone And Mineral Research
Quach, JM Askmyr, M Jovic, T Baker, EK Walsh, NC Harrison, SJ Neeson, P Ritchie, D Ebeling, PR Purton, LE
2015 Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure
Cell Reports
Askmyr, M White, KE Jovic, T King, HA Quach, JM Maluenda, JC Baker, EK Smeets, MF Walkley, CR Purton, LE
2015 Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma
Baker, EK Taylor, S Gupte, A Chalk, AM Bhattacharya, S Green, AC Martin, TJ Strbenac, D Robinson, MD Purton, LE Walkley, CR
2015 Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure
Sci Rep
Askmyr, M White, KE Jovic, T King, HA Quach, JM Maluenda, AC Baker, EK Smeets, MF Walkley, CR Purton, LE
2015 RAR gamma is a negative regulator of osteoclastogenesis
J. Steroid Biochem. Mol. Biol.
Green, AC Poulton, IJ Vrahnas, C Hausler, KD Walkley, CR Wu, JY Martin, TJ Gillespie, MT Chandraratna, RAS Quinn, JMW Sims, NA Purton, LE
2016 Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis
Exp Hematol
Li, JB Piskol, R Wall, M Lu, J Hartner, JC Sankaran, VG Orkin, SH Liddicoat, BJ Kingsley, PD Palis, J Chalk, AM Seeburg, PH Ramaswami, G Purton, LE Walkley, CR
2016 The role of vitamin A and retinoic acid receptor signaling in post-natal maintenance of bone
J. Steroid Biochem. Mol. Biol.
Green, AC Martin, TJ Purton, LE
2016 Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death
Bhattacharya, S Chalk, AM Ng, AJM Martin, TJ Zannettino, AC Purton, LE Lu, J Baker, EK Walkley, CR
2016 Retinoic Acid Receptor γ Regulates B and T Lymphopoiesis via Nestin-Expressing Cells in the Bone Marrow and Thymic Microenvironm
J Immunol
Nota, C Joseph, C Fletcher, JL Maluenda, AC Green, AC Purton, LE
2016 Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr
Mol. Cell. Biol.
Thoms, JAI Knezevic, K Liu, JJ Glaros, EN Thai, T Qiao, Q Campbell, H Packham, D Huang, YZ Papathanasiou, P Tunningley, R Whittle, B Yeung, AWS Chandrakanthan, V Hesson, L Chen, V Wong, JWH Purton, LE Ward, RL Thomas, SR Pimanda, JE
2016 T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments
Hawkins, ED Duarte, D Akinduro, O Khorshed, RA Passaro, D Nowicka, M Straszkowski, L Scott, MK Rothery, S Ruivo, N Foster, K Waibel, M Johnstone, RW Harrison, SJ Westerman, DA Quach, H Gribben, J Robinson, MD Purton, LE Bonnet, D Lo Celso, C
2016 PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells
Proc. Natl. Acad. Sci. U. S. A.
Chandrakanthan, V Yeola, A Kwan, JC Oliver, RA Qiao, Q Kang, YC Zarzour, P Beck, D Boelen, L Unnikrishnan, A Villanueva, JE Nunez, AC Knezevic, K Palu, C Nasrallah, R Carnell, M Macmillan, A Whan, R Yu, Y Hardy, P Grey, ST Gladbach, A Delerue, F Ittner, L Mobbs, R Walkley, CR Purton, LE Ward, RL Wong, JWH Hesson, LB Walsh, W Pimanda, JE
2017 Retinoic acid receptor signalling directly regulates osteoblast and adipocyte differentiation from mesenchymal progenitor cells
Exp. Cell Res.
Green, AC Kocovski, P Jovic, T Walia, MK Chandraratna, RAS Martin, TJ Baker, EK Purton, LE
2018 Extrinsic Regulation of Hematopoietic Stem Cells and Lymphocytes by Vitamin A
Curr. Stem. Cell Rep.
Joseph, C Green, AC Kwang, D Purton, LE
2018 Protagonist or antagonist? The complex roles of retinoids in the regulation of hematopoietic stem cells and their specification from pluripotent stem cells
Exp. Hematol.
Grace, CS Mikkola, HKA Dou, DR Calvanese, V Ronn, RE Purton, LE
2018 mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis
Sci Rep
Martin, SK Fitter, S El Khawanky, N Grose, RH Walkley, CR Purton, LE Ruegg, MA Hall, MN Gronthos, S Zannettino, ACW
2018 Retinoic Acid Receptor gamma Activity in Mesenchymal Stem Cells Regulates Endochondral Bone, Angiogenesis, and B Lymphopoiesis
J. Bone Miner. Res.
Green, AC Rudolph-Stringer, V Straszkowski, L Tjin, G Crimeen-Irwin, B Walia, M Martin, TJ Sims, NA Purton, LE
2018 Srsf2(P95H) initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells
Smeets, MF Tan, SY Xu, JJ Anande, G Unnikrishnan, A Chalk, AM Taylor, SR Pimanda, JE Wall, M Purton, LE Walkley, CR
2018 Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML
Cell Stem Cell
Duarte, D Hawkins, ED Akinduro, O Ang, H Filippo, KD Kong, IY Haltalli, M Ruivo, N Straszkowski, L Vervoort, SJ McLean, C Weber, TS Khorshed, R Pirillo, C Wei, A Ramasamy, SK Kusumbe, AP Duffy, K Adams, RH Purton, LE Carlin, LM Celso, CL
2019 The haematopoietic stem cell niche: a new player in cardiovascular disease?
Cardiovasc. Res.
Al-Sharea, A Lee, MKS Purton, LE Hawkins, ED Murphy, AJ
2019 Mesenchymal lineage cells and their importance in B lymphocyte niches
Green, AC Rudolph-Stringer, V Chantry, AD Wu, JY Purton, LE
2019 A population of nonneuronal GFR alpha 3-expressing cells in the bone marrow resembles nonmyelinating Schwann cells
Cell And Tissue Research
Thai, J Green, AC Stamp, LA Spencer, NJ Purton, LE Ivanusic, J
2019 Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal
Exp. Hematol.
Xu, JJ Srneets, MF Tan, SY Wall, M Purton, LE Walkley, CR
2019 Higher Intensity of Cell Surface Glucose-Regulated Protein 78 (csGRP78) Expression Is Seen in Patients with Early Progressive Disease/Mortality in a Cohort of Relapsed, Refractory Multiple Myeloma Patients Treated with Carfilzomib, Thalidomide and Dexamethasone
Ninkovic, S Harrison, S Straszkowski, L Quattrocchi, G Chng, WJ Purton, LE Quach, H
2019 Imaging methods used to study mouse and human HSC niches: Current and emerging technologies
Tjin, G Flores-Figueroa, E Duarte, D Straszkowski, L Scott, M Khorshed, RA Purton, LE Lo Celso, C
2019 Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly
Scientific Reports
Ku, M MacKinnon, RN Wall, M Narayan, N Walkley, C Cheng, HC Campbell, LJ Purton, LE Nandurkar, H
2019 All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia
Cell Death & Disease
Nguyen, CH Bauer, K Hackl, H Schlerka, A Koller, E Hladik, A Stoiber, D Zuber, J Staber, PB Hoelbl-Kovacic, A Purton, LE Grebien, F Wieser, R
2020 Sugar Rush: Supercharging Blood Cell Specification via the Inflammasome
Developmental Cell
Tjin, G Purton, LE
2020 All-transretinoic acid in non-promyelocytic acute myeloid leukemia: driver lesion dependent effects on leukemic stem cells
Cell Cycle
Nguyen, CH Grandits, AM Purton, LE Sill, H Wieser, R
2020 Effects of chemotherapy agents used to treat pediatric acute lymphoblastic leukemia patients on bone parameters and longitudinal growth of juvenile mice
Experimental Hematology
Straszkowski, L Jovic, T Castillo-Tandazo, W Ritchie, DS Purton, LE
2021 From the niche to malignant hematopoiesis and back: reciprocal interactions between leukemia and the bone marrow microenvironment
Jbmr Plus
Soto, CA Lo Celso, C Purton, LE Frisch, BJ
2021 Regulation of murine B lymphopoiesis by stromal cells
Immunological Reviews
Kwang, D Tjin, G Purton, LE
2021 Human, mouse, and dog bone marrow show similar mesenchymal stromal cells within a distinctive microenvironment
Experimental Hematology
Meza-Leon, B Gratzinger, D Aguilar-Navarro, AG Juarez-Aguilar, FG Rebel, VI Torlakovic, E Purton, LE Dorantes-Acosta, EM Escobar-Sanchez, A Dick, JE Flores-Figueroa, E
2021 The characterization of distinct populations of murine skeletal cells that have different roles in B lymphopoiesis
Green, AC Tjin, G Lee, SC Chalk, AM Straszkowski, L Kwang, D Baker, EK Quach, JM Kimura, T Wu, JY Purton, LE