Publications by Researcher: Sims, NA

YearTitleAuthor(s)
2011 Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment
Blood. 117(21):5631-42
Liddicoat, B Jovic, T Russell, MR Singbrant, S Izon, DJ Purton, LE Sankaran, VG Martin, TJ Sims, NA Walkley, CR
2012 Leukemia inhibitory factor: A paracrine mediator of bone metabolism
Growth Factors
Sims, NA Johnson, RW
2012 Contrasting roles of leukemia inhibitory factor in murine bone development and remodeling involve region-specific changes in vascularization
Journal Of Bone And Mineral Research
Poulton, IJ McGregor, NE Pompolo, S Walker, EC Sims, NA
2012 Proteinase-activated receptor-2 is required for normal osteoblast and osteoclast differentiation during skeletal growth and repair
Bone
Georgy, SR Pagel, CN Ghasem-Zadeh, A Zebaze, RMD Pike, RN Sims, NA Mackie, EJ
2012 Sustained RANKL Response to Parathyroid Hormone in Oncostatin M Receptor-Deficient Osteoblasts Converts Anabolic Treatment to a Catabolic Effect In Vivo
Journal Of Bone And Mineral Research
Walker, EC Poulton, IJ McGregor, NE Ho, PWM Allan, EH Quach, JM Martin, TJ Sims, NA
2012 Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation
Leukemia
Winkler, IG Pettit, AR Raggatt, LJ Jacobsen, RN Forristal, CE Barbier, V Nowlan, B Cisterne, A Bendall, LJ Sims, NA Levesque, JP
2012 Strain-Dependent Differences in Bone Development, Myeloid Hyperplasia, Morbidity and Mortality in Ptpn2-Deficient Mice
Plos One
Wiede, F Chew, SH van Vliet, C Poulton, IJ Kyparissoudis, K Sasmono, T Loh, K Tremblay, ML Godfrey, DI Sims, NA Tiganis, T
2012 Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance (vol 14, pg 684, 2011)
Cell Metabolism
Loh, K Fukushima, A Zhang, XM Galic, S Briggs, D Enriori, PJ Simonds, S Wiede, F Reichenbach, A Hauser, C Sims, NA Bence, KK Zhang, S Zhang, ZY Kahn, BB Neel, BG Andrews, ZB Cowley, MA Tiganis, T
2013 Delayed development of specific thyroid hormone-regulated events in transthyretin null mice
American Journal Of Physiology-endocrinology And Metabolism
Monk, JA Sims, NA Dziegielewska, KM Weiss, RE Ramsay, RG Richardson, SJ
2013 Prospective Histomorphometric and DXA Evaluation of Bone Remodeling in Imatinib-Treated CML Patients: Evidence for Site-Specific Skeletal Effects
Journal Of Clinical Endocrinology & Metabolism
Vandyke, K Fitter, S Drew, J Fukumoto, S Schultz, CG Sims, NA Yeung, DT Hughes, TP Zannettino, ACW
2013 Lactating Ctcgrp Nulls Lose Twice the Normal Bone Mineral Content due to Fewer Osteoblasts and More Osteoclasts, Whereas Bone Mass Is Fully Restored After Weaning in Association With Up-Regulation of Wnt Signaling and Other Novel Genes
Endocrinology
Collins, JN Kirby, BJ Woodrow, JP Gagel, RF Rosen, CJ Sims, NA Kovacs, CS
2013 EphrinB2/EphB4 inhibition in the osteoblast lineage modifies the anabolic response to parathyroid hormone
Journal Of Bone And Mineral Research
Takyar, FM Tonna, S Ho, PWM Crimeen-Irwin, B Baker, EK Martin, TJ Sims, NA
2013 Ciliary Neurotrophic Factor Inhibits Bone Formation and Plays a Sex-Specific Role in Bone Growth and Remodeling (vol 86, pg 261, 2010)
Calcified Tissue International
McGregor, NE Poulton, IJ Walker, EC Pompolo, S Quinn, JMW Martin, TJ Sims, NA
2013 EphB4 enhances the process of endochondral ossification and inhibits remodeling during bone fracture repair
Journal Of Bone And Mineral Research
Arthur, A Panagopoulos, RA Cooper, L Menicanin, D Parkinson, IH Codrington, JD Vandyke, K Zannettino, ACW Koblar, SA Sims, NA Matsuo, K Gronthos, S
2014 Cell-Cell Signaling: Broadening Our View of the Basic Multicellular Unit
Calcified Tissue International
Sims, NA Civitelli, R
2014 Regulation of cortical and trabecular bone mass by communication between osteoblasts, osteocytes and osteoclasts
Archives Of Biochemistry And Biophysics
Sims, NA Vrahnas, C
2014 Talking among Ourselves: Paracrine Control of Bone Formation within the Osteoblast Lineage
Calcified Tissue International
Tonna, S Sims, NA
2014 Myokines (muscle-derived cytokines and chemokines) including ciliary neurotrophic factor (CNTF) inhibit osteoblast differentiation
Bone
Johnson, RW White, JD Walker, EC Martin, TJ Sims, NA
2014 Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts
Cytokine
Le Goff, B Singbrant, S Tonkin, BA Martin, TJ Romas, E Sims, NA Walsh, NC
2014 gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation
Journal Of Endocrinology
Standal, T Johnson, RW McGregor, NE Poulton, IJ Ho, PWM Martin, TJ Sims, NA
2014 Decline in calcitonin receptor expression in osteocytes with age
Journal Of Endocrinology
Gooi, JH Chia, LY Walsh, NC Karsdal, MA Quinn, JMW Martin, TJ Sims, NA
2014 gp130 signalling in osteocytes is required for the anabolic action of parathyroid hormone
Journal Of Endocrinology
Standal, T Walker, EC McGregor, NE Poulton, IJ Brennan, HJ Johnson, RW Martin, TJ Sims, NA
2014 Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss
Proceedings Of The National Academy Of Sciences Of The United States Of America
Chen, WQ Foo, SS Rulli, NE Taylor, A Sheng, KC Herrero, LJ Herring, BL Lidbury, BA Li, RW Walsh, NC Sims, NA Smith, PN Mahalingam, S
2014 The Primary Function of gp130 Signaling in Osteoblasts Is To Maintain Bone Formation and Strength, Rather Than Promote Osteoclast Formation
Journal Of Bone And Mineral Research
Johnson, RW Brennan, HJ Vrahnas, C Poulton, IJ McGregor, NE Standal, T Walker, EC Koh, TT Nguyen, H Walsh, NC Forwood, MR Martin, TJ Sims, NA
2014 EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis
Faseb Journal
Tonna, S Takyar, FM Vrahnas, C Crimeen-Irwin, B Ho, PWM Poulton, IJ Brennan, HJ McGregor, NE Allan, EH Nguyen, H Forwood, MR Tatarczuch, L Mackie, EJ Martin, TJ Sims, NA
2015 Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders
Cytokine Growth Factor Rev.
Sims, NA
2015 RANKL/OPG; Critical role in bone physiology
Rev. Endocr. Metab. Disord.
Martin, TJ Sims, NA
2015 Quantifying the osteocyte network in the human skeleton
Bone
Buenzli, PR Sims, NA
2015 Calcitonin Physiology, Saved by a Lysophospholipid
Journal Of Bone And Mineral Research
Martin, TJ Sims, NA
2015 Arthritogenic alphaviruses: new insights into arthritis and bone pathology
Trends In Microbiology
Chen, WQ Foo, SS Sims, NA Herrero, LJ Walsh, NC Mahalingam, S
2015 Isolation and gene expression of haematopoietic-cell-free preparations of highly purified murine osteocytes
Bone
Chia, LY Walsh, NC Martin, TJ Sims, NA
2015 The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation
Plos Genetics
Ng, AJM Walia, MK Smeets, MF Mutsaers, AJ Sims, NA Purton, LE Walsh, NC Martin, TJ Walkley, CR
2015 Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle
J. Pathol.
Genet, F Kulina, I Vaquette, C Torossian, F Millard, S Pettit, AR Sims, NA Anginot, A Guerton, B Winkler, IG Barbier, V Lataillade, JJ Le Bousse-Kerdiles, MC Hutmacher, DW Levesque, JP
2015 Glycoprotein130 (Gp130)/interleukin-6 (IL-6) signalling in osteoclasts promotes bone formation in periosteal and trabecular bone
Bone
Johnson, RW McGregor, NE Brennan, HJ Crimeen-Irwin, B Poulton, IJ Martin, TJ Sims, NA
2015 Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection
Journal Of Virology
Chen, WQ Foo, SS Taylor, A Lulla, A Merits, A Hueston, L Forwood, MR Walsh, NC Sims, NA Herrero, LJ Mahalingam, S
2015 Parthenolide inhibits pro-inflammatory cytokine production and exhibits protective effects on progression of collagen-induced arthritis in a rat model
Scandinavian Journal Of Rheumatology
Liu, Q Zhao, J Tan, R Zhou, H Lin, Z Zheng, M Romas, E Xu, J Sims, NA
2015 RAR gamma is a negative regulator of osteoclastogenesis
J. Steroid Biochem. Mol. Biol.
Green, AC Poulton, IJ Vrahnas, C Hausler, KD Walkley, CR Wu, JY Martin, TJ Gillespie, MT Chandraratna, RAS Quinn, JMW Sims, NA Purton, LE
2015 Ubiquitous expression of the Pik3ca(H1047R) mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly
Faseb Journal
Kinross, KM Montgomery, KG Mangiafico, SP Hare, LM Kleinschmidt, M Bywater, MJ Poulton, IJ Vrahnas, C Henneicke, H Malaterre, J Waring, PM Cullinane, C Sims, NA McArthur, GA Andrikopoulos, S Phillips, WA
2016 Cell-specific paracrine actions of IL-6 family cytokines from bone, marrow and muscle that control bone formation and resorption
Int. J. Biochem. Cell Biol.
Sims, NA
2016 Coupling: The Influences of Immune and Bone Cells
Sims, NA Martin, J Quinn, JMW
2016 Response to "Letter to the Editor. On osteocyte density in the human body"
Bone
Buenzli, PR Sims, NA
2016 Anabolic action of parathyroid hormone (PTH) does not compromise bone matrix mineral composition or maturation
Bone
Vrahnas, C Pearson, TA Brunt, AR Forwood, MR Bambery, KR Tobin, MJ Martin, TJ Sims, NA
2016 Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass
J. Biol. Chem.
Walker, EC Johnson, RW Hu, YF Brennan, HJ Poulton, IJ Zhang, JG Jenkins, BJ Smyth, GK Nicola, NA Sims, NA
2016 Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification
Development
Tonna, S Poulton, IJ Taykar, F Ho, PWM Tonkin, B Crimeen-Irwin, B Tatarczuch, L McGregor, NE Mackie, EJ Martin, TJ Sims, NA
2016 Loss of G(s)alpha in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy
J. Biol. Chem.
Sinha, P Aarnisalo, P Chubb, R Poulton, IJ Guo, J Nachtrab, G Kimura, T Swami, S Saeed, H Chen, M Weinstein, LS Schipani, E Sims, NA Kronenberg, HM Wu, JY
2017 Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6
Nat. Commun.
Cho, DC Brennan, HJ Johnson, RW Poulton, IJ Gooi, JH Tonkin, BA McGregor, NE Walker, EC Handelsman, DJ Martin, TJ Sims, NA
2017 Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications
Jci Insight
Torossian, F Guerton, B Anginot, A Alexander, KA Desterke, C Soave, S Tseng, HW Arouche, N Boutin, L Kulina, I Salga, M Jose, B Pettit, AR Clay, D Rochet, N Vlachos, E Genet, G Debaud, C Denormandie, P Genet, F Sims, NA Banzet, S Levesque, JP Lataillade, JJ Le Bousse-Kerdiles, MC
2018 Biomechanical testing of the calcified metacarpal articular surface and its association with subchondral bone microstructure in Thoroughbred racehorses
Equine Vet. J.
Williamson, AJ Sims, NA Thomas, CDL Lee, PVS Stevenson, MA Whitton, RC
2018 Macrophages Driving Heterotopic Ossification: Convergence of Genetically-Driven and Trauma-Driven Mechanisms
J. Bone Miner. Res.
Levesque, JP Sims, NA Pettit, AR Alexander, KA Tseng, HW Torossian, F Genet, F Lataillade, JJ Le Bousse-Kerdiles, MC
2018 Adolescent Inhalant Abuse Results in Adrenal Dysfunction and a Hypermetabolic Phenotype with Persistent Growth Impairments
Neuroendocrinology
Crossin, R Andrews, ZB Sims, NA Pang, T Mathai, M Gooi, JH Stefanidis, A Oldfield, BJ Lawrence, AJ Duncan, JR
2018 IL-6 trans-signalling mediates trabecular, but not cortical, bone loss after ovariectomy
Bone
Lazzaro, L Tonkin, BA Poulton, IJ McGregor, NE Ferlin, W Sims, NA
2018 Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner
Front. Endocrinol.
Johnson, RW Sun, Y Ho, PWM Chan, ASM Johnson, JA Pavlos, NJ Sims, NA Martin, TJ
2018 Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease
J. Clin. Invest.
Tsantikos, E Lau, M Castelino, CMN Maxwell, MJ Passey, SL Hansen, MJ McGregor, NE Sims, NA Steinfort, DP Irving, LB Anderson, GP Hibbs, ML
2018 Absence of Calcitriol Causes Increased Lactational Bone Loss and Lower Milk Calcium but Does Not Impair Post-lactation Bone Recovery in Cyp27b1 Null Mice
J. Bone Miner. Res.
Gillies, BR Ryan, BA Tonkin, BA Poulton, IJ Ma, Y Kirby, BJ St-Arnaud, R Sims, NA Kovacs, CS
2018 Differing Effects of Parathyroid Hormone, Alendronate, and Odanacatib on Bone Formation and on the Mineralization Process in Intracortical and Endocortical Bone of Ovariectomized Rabbits
Calcif. Tissue Int.
Vrahnas, C Buenzli, PR Pearson, TA Pennypacker, BL Tobin, MJ Bambery, KR Duong, LT Sims, NA
2018 Retinoic Acid Receptor gamma Activity in Mesenchymal Stem Cells Regulates Endochondral Bone, Angiogenesis, and B Lymphopoiesis
J. Bone Miner. Res.
Green, AC Rudolph-Stringer, V Straszkowski, L Tjin, G Crimeen-Irwin, B Walia, M Martin, TJ Sims, NA Purton, LE
2018 Osteoblasts Are Rapidly Ablated by Virus-Induced Systemic Inflammation following Lymphocytic Choriomeningitis Virus or Pneumonia Virus of Mice Infection in Mice
J. Immunol.
Maltby, S Lochrin, AJ Bartlett, B Tay, HL Weaver, J Poulton, IJ Plank, MW Rosenberg, HF Sims, NA Foster, PS
2018 Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein
J. Bone Miner. Res.
Ansari, N Ho, PWM Crimeen-Irwin, B Poulton, IJ Brunt, AR Forwood, MR Pajevic, PD Gooi, JH Martin, TJ Sims, NA
2019 Overcoming natural Wnt inhibition to optimize therapy
Nature Reviews Rheumatology
Sims, NA
2019 Cellular Processes by Which Osteoblasts and Osteocytes Control Bone Mineral Deposition and Maturation Revealed by Stage-Specific EphrinB2 Knockdown
Current Osteoporosis Reports
Blank, M Sims, NA
2019 Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar dynein function in primary cilia
Human Molecular Genetics
King, A Hoch, NC McGregor, NE Sims, NA Smyth, IM Heierhorst, J
2019 Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persistent generation of cyclic AMP through an endocytosis-dependent mechanism
Biochemical Pharmacology
Ho, PWM Chan, AS Pavlos, NJ Sims, NA Martin, TJ
2019 Effect of rapamycin on bone mass and strength in the alpha 2(I)-G610C mouse model of osteogenesis imperfecta
J. Cell. Mol. Med.
Bateman, JF Sampurno, L Maurizi, A Lamande, SR Sims, NA Cheng, TL Schindeler, A Little, DG
2019 Deleting Suppressor of Cytokine Signaling-3 in chondrocytes reduces bone growth by disrupting mitogen-activated protein kinase signaling
Osteoarthritis And Cartilage
Liu, X D’Cruz, AA Hansen, J Croker, BA Lawlor, KE Sims, NA Wicks, IP
2019 Osteopontin is An Important Regulative Component of the Fetal Bone Marrow Hematopoietic Stem Cell Niche
Cells
Cao, HM Cao, B Heazlewood, CK Domingues, M Sun, X Debele, E McGregor, NE Sims, NA Heazlewood, SY Nilsson, SK
2019 Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs
Matrix Biology
Gauci, SJ Golub, SB Tatarczuch, L Lee, E Chan, D Walsh, NC Little, CB Stanton, H Lokmic, Z Sims, NA Mackie, EJ Fosang, AJ
2019 IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis
Journal Of Biological Chemistry
McGregor, NE Murat, M Elango, J Poulton, IJ Walker, EC Crimeen-Irwin, B Ho, PWM Gooi, JH Martin, TJ Sims, NA
2019 Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone (vol 10, 3436, 2019)
Nature Communications
Vrahnas, C Blank, M Dite, TA Tatarczuch, L Ansari, N Crimeen-Irwin, B Nguyen, H Forwood, MR Hu, YF Ikegame, M Bambery, KR Petibois, C Mackie, EJ Tobin, MJ Smyth, GK Oakhill, JS Martin, TJ Sims, NA
2019 Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
Nature Communications
Vrahnas, C Blank, M Dite, TA Tatarczuch, L Ansari, N Crimeen-Irwinl, B Nguyen, H Forwood, MR Hu, YF Ikegame, M Bambery, KR Petibois, C Mackie, EJ Tobin, MJ Smyth, GK Oakhill, JS Martin, TJ Sims, NA
2020 The JAK1/STAT3/SOCS3 axis in bone development, physiology, and pathology
Experimental And Molecular Medicine
Sims, NA
2020 Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms
Annual Review Of Physiology, Vol 82
Sims, NA Martin, TJ
2020 Testing Bone Formation Induction by Calvarial Injection Assay in vivo
Bio-protocol
McGregor, NE Poulton, IJ Walker, EC Sims, NA
2020 Asymmetric midshaft femur remodeling in an adult male with left sided hip joint ankylosis, Metal Period Nagsabaran, Philippines
International Journal Of Paleopathology
Miszkiewicz, JJ Rider, C Kealy, S Vrahnas, C Sims, NA Vongsvivut, J Tobin, MJ Bolunia, MJLA De Leon, AS Penalosa, AL Pagulayan, PS Soriano, AV Page, R Oxenham, MF
2020 Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes
Elife
Walker, EC Truong, K McGregor, NE Poulton, IJ Isojima, T Gooi, JH Martin, TJ Sims, NA
2020 Interaction between osteocyte SOCS3-dependent signaling and the bone marrow microenvironment maintains cortical bone integrity
Journal Of Bone And Mineral Research
Isojima, T Walker, EC Crimeen-Irwin, B Poulton, IJ McGregor, NE Gooi, JH Martin, TJ Sims, NA
2021 Rothmund-Thomson Syndrome-Like RECQL4 Truncating Mutations Cause a Haploinsufficient Low-Bone-Mass Phenotype in Mice
Molecular And Cellular Biology
Castillo-Tandazo, W Frazier, AE Sims, NA Smeets, MF Walkley, CR
2021 Bone loss markers in the earliest Pacific Islanders
Scientific Reports
Miszkiewicz, JJ Valentin, F Vrahnas, C Sims, NA Vongsvivut, J Tobin, MJ Clark, G
2021 Measuring Bone Volume at Multiple Densities by Micro-computed Tomography
Bio-protocol
Walker, EC McGregor, NE Chan, ASM Sims, NA