| Year | Title | Author(s) |
|---|
| 2012 |
AMPK functions as an adenylate charge-regulated protein kinase
Trends In Endocrinology And Metabolism |
Oakhill, JS Scott, JW Kemp, BE |
| 2014 |
ATP sensitive bi-quinoline activator of the AMP-activated protein kinase
Biochemical And Biophysical Research Communications |
Scott, JW Oakhill, JS Ling, NXY Langendorf, CG Foitzik, RC Kemp, BE Issinger, OG |
| 2014 |
Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling
Chemistry & Biology |
Scott, JW Ling, NM Issa, SMA Dite, TA O’Brien, MT Chen, ZP Galic, S Langendorf, CG Steinberg, GR Kemp, BE Oakhill, JS |
| 2015 |
Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder
Sci Rep |
Scott, JW Park, E Rodriguiz, RM Oakhill, JS Issa, SMA O’Brien, MT Dite, TA Langendorf, CG Wetsel, WC Means, AR Kemp, BE |
| 2015 |
Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity
Biochem. J. |
Ford, RJ Fullerton, MD Pinkosky, SL Day, EA Scott, JW Oakhill, JS Bujak, AL Smith, BK Crane, JD Blumer, RM Marcinko, K Kemp, BE Gerstein, HC Steinberg, GR |
| 2015 |
SnRK1 from Arabidopsis thaliana is an atypical AMPK
Plant Journal |
Emanuelle, S Hossain, MI Moller, IE Pedersen, HL van de Meene, AML Doblin, MS Koay, A Oakhill, JS Scott, JW Willats, WGT Kemp, BE Bacic, A Gooley, PR Stapleton, DI |
| 2015 |
Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release
Chem Biol |
Langendorf, CG Steinberg, GR Galic, S Issa, SMA Birnberg, NC Scott, JW Dite, TA Kay, TW Ling, NXY Thomas, HE Foitzik, R Weng, QP Kemp, BE Graham, KL Oakhill, JS |
| 2015 |
Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release
Chem. Biol. |
Scott, JW Galic, S Graham, KL Foitzik, R Ling, NXY Dite, TA Issa, SMA Langendorf, CG Weng, QP Thomas, HE Kay, TW Birnberg, NC Steinberg, GR Kemp, BE Oakhill, JS |
| 2016 |
beta-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase
Sci Rep |
Ali, N Ling, NM Krishnamurthy, S Oakhill, JS Scott, JW Stapleton, DI Kemp, BE Anand, GS Gooley, PR |
| 2016 |
Cyclin-dependent kinase-mediated phosphorylation of breast cancer metastasis suppressor 1 (BRMS1) affects cell migration
Cell Cycle |
Roesley, SNA Suryadinata, R Morrish, E Tan, AR Issa, SMA Oakhill, JS Bernard, O Welch, DR Sarcevic, B |
| 2016 |
Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding
Nat. Commun. |
Langendorf, CG Ngoei, KRW Scott, JW Ling, NXY Issa, SMA Gorman, MA Parker, MW Sakamoto, K Oakhill, JS Kemp, BE |
| 2017 |
Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation
Sci Rep |
O’Brien, MT Oakhill, JS Ling, NMXY Langendorf, CG Hoque, A Dite, TA Means, AR Kemp, BE Scott, JW |
| 2017 |
Mdivi-1 Protects Human W8B2(+) Cardiac Stem Cells from Oxidative Stress and Simulated Ischemia-Reperfusion Injury
Stem Cells Dev. |
Rosdah, AA Bond, ST Sivakumaran, P Hoque, A Oakhill, JS Drew, BG Delbridge, LMD Lim, SY |
| 2017 |
The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
Nat. Commun. |
Dite, TA Ling, NXY Scott, JW Hoque, A Galic, S Parker, BL Ngoei, KRW Langendorf, CG O’Brien, MT Kundu, M Viollet, B Steinberg, GR Sakamoto, K Kemp, BE Oakhill, JS |
| 2018 |
Transient Expression of AMPK Heterotrimer Complexes in Mammalian Cells
Methods Mol. Biol. |
Oakhill, JS Scott, JW Dite, TA |
| 2018 |
Visualizing AMPK Drug Binding Sites Through Crystallization of Full-Length Phosphorylated alpha 2 beta 1 gamma 1 Heterotrimer
Methods Mol. Biol. |
Langendorf, CG Oakhill, JS Kemp, BE |
| 2018 |
Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion
Cell Death Differ. |
Lindqvist, LM Frank, D McArthur, K Dite, TA Lazarou, M Oakhill, JS Kile, BT Vaux, DL |
| 2018 |
1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors
Molecules |
Asquith, CRM Godoi, PH Counago, RM Laitinen, T Scott, JW Langendorf, CG Oakhill, JS Drewry, DH Zuercher, WJ Koutentis, PA Willson, TM Kalogirou, AS |
| 2018 |
AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965
J. Biol. Chem. |
Dite, TA Langendorf, CG Hoque, A Galic, S Rebello, RJ Ovens, AJ Lindqvist, LM Ngoei, KRW Ling, NXY Furic, L Kemp, BE Scott, JW Oakhill, JS |
| 2018 |
Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells
Cell Death Discov. |
Hogue, A Sivakumaran, P Bond, ST Ling, NXY Kong, AM Scott, JW Bandara, N Hernandez, D Liu, GS Wong, RCB Ryan, MT Hausenloy, DJ Kemp, BE Oakhill, JS Drew, BG Pebay, A Lim, SY |
| 2018 |
Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4
Cell Chem. Biol. |
Ngoei, KRW Langendorf, CG Ling, NXY Hoque, A Varghese, S Camerino, MA Walker, SR Bozikis, YE Dite, TA Ovens, AJ Smiles, WJ Jacobs, R Huang, H Parker, MW Scott, JW Rider, MH Foitzik, RC Kemp, BE Baell, JB Oakhill, JS |
| 2019 |
Allosteric regulation of AMP-activated protein kinase by adenylate nucleotides and small-molecule drugs
Biochemical Society Transactions |
Matos, ALDA Oakhill, JS Moreira, J Loh, K Galic, S Scott, JW |
| 2019 |
Quantitative proteomic analyses of dynamic signalling events associated with neuronal death in excitotoxicity
Journal Of Neurochemistry |
Hoque, MA Williamson, NA Ang, CS Oakhill, JS Cheng, HC |
| 2019 |
Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death
Cell Death Dis. |
Hoque, A Williamson, NA Ameen, SS Ciccotosto, GD Hossain, MI Oakhill, JS Ng, DCH Ang, CS Cheng, HC |
| 2019 |
AMP-activated protein kinase complexes containing the beta 2 regulatory subunit are up-regulated during and contribute to adipogenesis
Biochemical Journal |
Katwan, OJ Aighamdi, F Almabrouk, TA Mancini, SJ Kennedy, S Oakhill, JS Scott, JW Salt, IP |
| 2019 |
Import of extracellular ATP in yeast and man modulates AMPK and TORC1 signalling
J. Cell Sci. |
Forte, GM Davie, E Lie, S Franz-Wachtel, M Ovens, AJ Wang, TT Oakhill, JS Macek, B Hagan, IM Petersen, J |
| 2019 |
Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry
Embo Journal |
Nelson, ME Parker, BL Burchfield, JG Hoffman, NJ Needham, EJ Cooke, KC Naim, T Sylow, L Ling, NXY Francis, D Norris, DM Chaudhuri, R Oakhill, JS Richter, EA Lynch, GS Stockli, J James, DE |
| 2019 |
Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
Nature Communications |
Vrahnas, C Blank, M Dite, TA Tatarczuch, L Ansari, N Crimeen-Irwinl, B Nguyen, H Forwood, MR Hu, YF Ikegame, M Bambery, KR Petibois, C Mackie, EJ Tobin, MJ Smyth, GK Oakhill, JS Martin, TJ Sims, NA |
| 2019 |
Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone (vol 10, 3436, 2019)
Nature Communications |
Vrahnas, C Blank, M Dite, TA Tatarczuch, L Ansari, N Crimeen-Irwin, B Nguyen, H Forwood, MR Hu, YF Ikegame, M Bambery, KR Petibois, C Mackie, EJ Tobin, MJ Smyth, GK Oakhill, JS Martin, TJ Sims, NA |
| 2019 |
ATP synthase inhibitory factor 1 (IF1), a novel myokine, regulates glucose metabolism by AMPK and Akt dual pathways
Faseb Journal |
Lee, HJ Moon, J Chung, I Chung, JH Park, C Lee, JO Han, JA Kang, MJ Yoo, EH Kwak, SY Jo, G Park, W Park, J Kim, KM Lim, S Ngoei, KRW Ling, NXY Oakhill, JS Galic, S Murray-Segal, L Kemp, BE Mantzoros, CS Krauss, RM Shin, MJ Kim, HS |
| 2020 |
New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology
Pharmacology & Therapeutics |
Rosdah, AA Smiles, WJ Oakhill, JS Scott, JW Langendorf, CG Delbridge, LMD Holien, JK Lim, SY |
| 2020 |
In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds
Molecules |
O’Byrne, SN Scott, JW Pilotte, JR Santiago, AD Langendorf, CG Oakhill, JS Eduful, BJ Counago, RM Wells, CI Zuercher, WJ Willson, TM Drewry, DH |
| 2020 |
DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy
Autophagy |
Puustinen, P Keldsbo, A Corcelle-Termeau, E Ngoei, K Sonder, SL Farkas, T Kaae Andersen, K Oakhill, JS Jaattela, M |
| 2020 |
Functional analysis of an R311C variant of Ca2+-calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder
Bipolar Disorders |
Ling, NXY Langendorf, CG Hoque, A Galic, S Loh, K Kemp, BE Gundlach, AL Oakhill, JS Scott, JW |
| 2020 |
Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism
Molecular Metabolism |
Hoffman, NJ Whitfield, J Janzen, NR Belhaj, MR Galic, S Murray-Segal, L Smiles, WJ Ling, NXY Dite, TA Scott, JW Oakhill, JS Brink, R Kemp, BE Hawley, JA |
| 2020 |
CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins
Journal Of Biological Chemistry |
Langendorf, CG O’Brien, MT Ngoei, KRW McAloon, LM Dhagat, U Hoque, A Ling, NXY Dite, TA Galic, S Loh, K Parker, MW Oakhill, JS Kemp, BE Scott, JW |
| 2020 |
mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress
Nature Metabolism |
Ling, NXY Kaczmarek, A Hoque, A Davie, E Ngoei, KRW Morrison, KR Smiles, WJ Forte, GM Wang, TT Lie, S Dite, TA Langendorf, CG Scott, JW Oakhill, JS Petersen, J |
| 2020 |
The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPK alpha 2
Febs Journal |
Lee, JO Byun, WS Kang, MJ Han, JA Moon, J Shin, MJ Lee, HJ Chung, JH Lee, JS Son, CG Song, KH Kim, TW Lee, ES Kim, HM Chung, CH Ngoei, KRW Ling, NXY Oakhill, JS Galic, S Murray-Segal, L Kemp, BE Kim, KM Lim, S Kim, HS |
| 2020 |
Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK beta 1 isoforms
Nature Metabolism |
Pinkosky, SL Scott, JW Desjardins, EM Smith, BK Day, EA Ford, RJ Langendorf, CG Ling, NXY Nero, TL Loh, K Galic, S Hoque, A Smiles, WJ Ngoei, KRW Parker, MW Yan, Y Melcher, K Kemp, BE Oakhill, JS Steinberg, GR |
| 2021 |
Regulation of Pancreatic beta-Cell Function by the NPY System
Endocrinology |
Yang, CH Onda, DA Oakhill, JS Scott, JW Galic, S Loh, K |
| 2021 |
Post-Translational Modifications of the Energy Guardian AMP-Activated Protein Kinase
International Journal Of Molecular Sciences |
Ovens, AJ Scott, JW Langendorf, CG Kemp, BE Oakhill, JS Smiles, WJ |
| 2021 |
Molecular Mechanisms Underlying the Beneficial Effects of Exercise on Brain Function and Neurological Disorders
International Journal Of Molecular Sciences |
Nay, K Smiles, WJ Kaiser, J McAloon, LM Loh, K Galic, S Oakhill, JS Gundlach, AL Scott, JW |
| 2021 |
Compound- and fiber type-selective requirement of AMPKy3 for insulin-independent glucose uptake in skeletal muscle
Molecular Metabolism |
Rhein, P Desjardins, EM Rong, P Ahwazi, D Bonhoure, N Stolte, J Santos, MD Ovens, AJ Ehrlich, AM Garcia, JLS Ouyang, Q Yabut, JM Membrez, M Kjolby, M Jessen, N Oakhill, JS Treebak, JT Maire, P Scott, JW Sanders, MJ Descombes, P Chen, S Steinberg, GR Sakamoto, K |
| 2021 |
Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes
Journal Of Medicinal Chemistry |
Eduful, BJ O’Byrne, SN Temme, L Asquith, CRM Liang, Y Picado, A Pilotte, JR Hossain, MA Wells, CI Zuercher, WJ Catta-Preta, CMC Ramos, PZ Santiago, AD Counago, RM Langendorf, CG Nay, K Oakhill, JS Pulliam, TL Lin, C Awad, D Willson, TM Frigo, DE Scott, JW Drewry, DH |
| 2022 |
Neuropeptide Y1 receptor antagonism protects beta-cells and improves glycemic control in type 2 diabetes
Molecular Metabolism |
Yang, CH Ann-Onda, D Lin, XZ Fynch, S Nadarajah, S Pappas, EG Liu, X Scott, JW Oakhill, JS Galic, S Shi, YC Moreno-Asso, A Smith, C Loudovaris, T Levinger, I Eizirik, DL Laybutt, DR Herzog, H Thomas, HE Loh, K |
| 2022 |
Personalized phosphoproteomics identifies functional signaling
Nature Biotechnology |
Needham, EJ Hingst, JR Parker, BL Morrison, KR Yang, G Onslev, J Kristensen, JM Hojlund, K Ling, NMXY Oakhill, JS Richter, EA Kiens, B Petersen, J Pehmoller, C James, DE Wojtaszewski, JFP Humphrey, SJ |
| 2022 |
An AMPKa2-specific phospho-switch controls lysosomal targeting for activation
Cell Reports |
Morrison, KR Smiles, WJ Ling, NXY Hoque, A Shea, G Ngoei, KRW Yu, DY Murray-Segal, L Scott, JW Galic, S Kemp, BE Petersen, J Oakhill, JS |