Publications by Researcher: Oakhill, JS

YearTitleAuthor(s)
2012 AMPK functions as an adenylate charge-regulated protein kinase
Trends In Endocrinology And Metabolism
Oakhill, JS Scott, JW Kemp, BE
2014 ATP sensitive bi-quinoline activator of the AMP-activated protein kinase
Biochemical And Biophysical Research Communications
Scott, JW Oakhill, JS Ling, NXY Langendorf, CG Foitzik, RC Kemp, BE Issinger, OG
2014 Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling
Chemistry & Biology
Scott, JW Ling, NM Issa, SMA Dite, TA O’Brien, MT Chen, ZP Galic, S Langendorf, CG Steinberg, GR Kemp, BE Oakhill, JS
2015 Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder
Sci Rep
Scott, JW Park, E Rodriguiz, RM Oakhill, JS Issa, SMA O’Brien, MT Dite, TA Langendorf, CG Wetsel, WC Means, AR Kemp, BE
2015 Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity
Biochem. J.
Ford, RJ Fullerton, MD Pinkosky, SL Day, EA Scott, JW Oakhill, JS Bujak, AL Smith, BK Crane, JD Blumer, RM Marcinko, K Kemp, BE Gerstein, HC Steinberg, GR
2015 SnRK1 from Arabidopsis thaliana is an atypical AMPK
Plant Journal
Emanuelle, S Hossain, MI Moller, IE Pedersen, HL van de Meene, AML Doblin, MS Koay, A Oakhill, JS Scott, JW Willats, WGT Kemp, BE Bacic, A Gooley, PR Stapleton, DI
2015 Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release
Chem Biol
Foitzik, R Weng, QP Kemp, BE Graham, KL Langendorf, CG Steinberg, GR Galic, S Issa, SMA Birnberg, NC Scott, JW Dite, TA Kay, TW Ling, NXY Thomas, HE Oakhill, JS
2015 Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release
Chem. Biol.
Scott, JW Galic, S Graham, KL Foitzik, R Ling, NXY Dite, TA Issa, SMA Langendorf, CG Weng, QP Thomas, HE Kay, TW Birnberg, NC Steinberg, GR Kemp, BE Oakhill, JS
2016 beta-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase
Sci Rep
Ali, N Ling, NM Krishnamurthy, S Oakhill, JS Scott, JW Stapleton, DI Kemp, BE Anand, GS Gooley, PR
2016 Cyclin-dependent kinase-mediated phosphorylation of breast cancer metastasis suppressor 1 (BRMS1) affects cell migration
Cell Cycle
Roesley, SNA Suryadinata, R Morrish, E Tan, AR Issa, SMA Oakhill, JS Bernard, O Welch, DR Sarcevic, B
2016 Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding
Nat. Commun.
Langendorf, CG Ngoei, KRW Scott, JW Ling, NXY Issa, SMA Gorman, MA Parker, MW Sakamoto, K Oakhill, JS Kemp, BE
2017 Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation
Sci Rep
O’Brien, MT Oakhill, JS Ling, NMXY Langendorf, CG Hoque, A Dite, TA Means, AR Kemp, BE Scott, JW
2017 Mdivi-1 Protects Human W8B2(+) Cardiac Stem Cells from Oxidative Stress and Simulated Ischemia-Reperfusion Injury
Stem Cells Dev.
Rosdah, AA Bond, ST Sivakumaran, P Hoque, A Oakhill, JS Drew, BG Delbridge, LMD Lim, SY
2017 The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
Nat. Commun.
Dite, TA Ling, NXY Scott, JW Hoque, A Galic, S Parker, BL Ngoei, KRW Langendorf, CG O’Brien, MT Kundu, M Viollet, B Steinberg, GR Sakamoto, K Kemp, BE Oakhill, JS
2018 Transient Expression of AMPK Heterotrimer Complexes in Mammalian Cells
Methods Mol. Biol.
Oakhill, JS Scott, JW Dite, TA
2018 Visualizing AMPK Drug Binding Sites Through Crystallization of Full-Length Phosphorylated alpha 2 beta 1 gamma 1 Heterotrimer
Methods Mol. Biol.
Langendorf, CG Oakhill, JS Kemp, BE
2018 Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion
Cell Death Differ.
Lindqvist, LM Frank, D McArthur, K Dite, TA Lazarou, M Oakhill, JS Kile, BT Vaux, DL
2018 1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors
Molecules
Asquith, CRM Godoi, PH Counago, RM Laitinen, T Scott, JW Langendorf, CG Oakhill, JS Drewry, DH Zuercher, WJ Koutentis, PA Willson, TM Kalogirou, AS
2018 AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965
J. Biol. Chem.
Dite, TA Langendorf, CG Hoque, A Galic, S Rebello, RJ Ovens, AJ Lindqvist, LM Ngoei, KRW Ling, NXY Furic, L Kemp, BE Scott, JW Oakhill, JS
2018 Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells
Cell Death Discov.
Hogue, A Sivakumaran, P Bond, ST Ling, NXY Kong, AM Scott, JW Bandara, N Hernandez, D Liu, GS Wong, RCB Ryan, MT Hausenloy, DJ Kemp, BE Oakhill, JS Drew, BG Pebay, A Lim, SY
2018 Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4
Cell Chem. Biol.
Ngoei, KRW Langendorf, CG Ling, NXY Hoque, A Varghese, S Camerino, MA Walker, SR Bozikis, YE Dite, TA Ovens, AJ Smiles, WJ Jacobs, R Huang, H Parker, MW Scott, JW Rider, MH Foitzik, RC Kemp, BE Baell, JB Oakhill, JS
2019 Allosteric regulation of AMP-activated protein kinase by adenylate nucleotides and small-molecule drugs
Biochemical Society Transactions
Matos, ALDA Oakhill, JS Moreira, J Loh, K Galic, S Scott, JW
2019 Quantitative proteomic analyses of dynamic signalling events associated with neuronal death in excitotoxicity
Journal Of Neurochemistry
Hoque, MA Williamson, NA Ang, CS Oakhill, JS Cheng, HC
2019 AMP-activated protein kinase complexes containing the beta 2 regulatory subunit are up-regulated during and contribute to adipogenesis
Biochemical Journal
Katwan, OJ Aighamdi, F Almabrouk, TA Mancini, SJ Kennedy, S Oakhill, JS Scott, JW Salt, IP
2019 Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death
Cell Death Dis.
Hoque, A Williamson, NA Ameen, SS Ciccotosto, GD Hossain, MI Oakhill, JS Ng, DCH Ang, CS Cheng, HC
2019 Import of extracellular ATP in yeast and man modulates AMPK and TORC1 signalling
J. Cell Sci.
Forte, GM Davie, E Lie, S Franz-Wachtel, M Ovens, AJ Wang, TT Oakhill, JS Macek, B Hagan, IM Petersen, J
2019 Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry
Embo Journal
Nelson, ME Parker, BL Burchfield, JG Hoffman, NJ Needham, EJ Cooke, KC Naim, T Sylow, L Ling, NXY Francis, D Norris, DM Chaudhuri, R Oakhill, JS Richter, EA Lynch, GS Stockli, J James, DE
2019 Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone (vol 10, 3436, 2019)
Nature Communications
Vrahnas, C Blank, M Dite, TA Tatarczuch, L Ansari, N Crimeen-Irwin, B Nguyen, H Forwood, MR Hu, YF Ikegame, M Bambery, KR Petibois, C Mackie, EJ Tobin, MJ Smyth, GK Oakhill, JS Martin, TJ Sims, NA
2019 Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
Nature Communications
Vrahnas, C Blank, M Dite, TA Tatarczuch, L Ansari, N Crimeen-Irwinl, B Nguyen, H Forwood, MR Hu, YF Ikegame, M Bambery, KR Petibois, C Mackie, EJ Tobin, MJ Smyth, GK Oakhill, JS Martin, TJ Sims, NA
2019 ATP synthase inhibitory factor 1 (IF1), a novel myokine, regulates glucose metabolism by AMPK and Akt dual pathways
Faseb Journal
Lee, HJ Moon, J Chung, I Chung, JH Park, C Lee, JO Han, JA Kang, MJ Yoo, EH Kwak, SY Jo, G Park, W Park, J Kim, KM Lim, S Ngoei, KRW Ling, NXY Oakhill, JS Galic, S Murray-Segal, L Kemp, BE Mantzoros, CS Krauss, RM Shin, MJ Kim, HS
2020 New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology
Pharmacology & Therapeutics
Rosdah, AA Smiles, WJ Oakhill, JS Scott, JW Langendorf, CG Delbridge, LMD Holien, JK Lim, SY
2020 In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds
Molecules
O’Byrne, SN Scott, JW Pilotte, JR Santiago, AD Langendorf, CG Oakhill, JS Eduful, BJ Counago, RM Wells, CI Zuercher, WJ Willson, TM Drewry, DH
2020 Functional analysis of an R311C variant of Ca2+-calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder
Bipolar Disorders
Ling, NXY Langendorf, CG Hoque, A Galic, S Loh, K Kemp, BE Gundlach, AL Oakhill, JS Scott, JW
2020 DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy
Autophagy
Puustinen, P Keldsbo, A Corcelle-Termeau, E Ngoei, K Sonder, SL Farkas, T Kaae Andersen, K Oakhill, JS Jaattela, M
2020 Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism
Molecular Metabolism
Hoffman, NJ Whitfield, J Janzen, NR Belhaj, MR Galic, S Murray-Segal, L Smiles, WJ Ling, NXY Dite, TA Scott, JW Oakhill, JS Brink, R Kemp, BE Hawley, JA
2020 CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins
Journal Of Biological Chemistry
Langendorf, CG O’Brien, MT Ngoei, KRW McAloon, LM Dhagat, U Hoque, A Ling, NXY Dite, TA Galic, S Loh, K Parker, MW Oakhill, JS Kemp, BE Scott, JW
2020 mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress
Nature Metabolism
Ling, NXY Kaczmarek, A Hoque, A Davie, E Ngoei, KRW Morrison, KR Smiles, WJ Forte, GM Wang, TT Lie, S Dite, TA Langendorf, CG Scott, JW Oakhill, JS Petersen, J
2020 The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPK alpha 2
Febs Journal
Lee, JO Byun, WS Kang, MJ Han, JA Moon, J Shin, MJ Lee, HJ Chung, JH Lee, JS Son, CG Song, KH Kim, TW Lee, ES Kim, HM Chung, CH Ngoei, KRW Ling, NXY Oakhill, JS Galic, S Murray-Segal, L Kemp, BE Kim, KM Lim, S Kim, HS
2020 Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK beta 1 isoforms
Nature Metabolism
Pinkosky, SL Scott, JW Desjardins, EM Smith, BK Day, EA Ford, RJ Langendorf, CG Ling, NXY Nero, TL Loh, K Galic, S Hoque, A Smiles, WJ Ngoei, KRW Parker, MW Yan, Y Melcher, K Kemp, BE Oakhill, JS Steinberg, GR
2021 Post-Translational Modifications of the Energy Guardian AMP-Activated Protein Kinase
International Journal Of Molecular Sciences
Ovens, AJ Scott, JW Langendorf, CG Kemp, BE Oakhill, JS Smiles, WJ
2021 Molecular Mechanisms Underlying the Beneficial Effects of Exercise on Brain Function and Neurological Disorders
International Journal Of Molecular Sciences
Nay, K Smiles, WJ Kaiser, J McAloon, LM Loh, K Galic, S Oakhill, JS Gundlach, AL Scott, JW