Publications by Researcher: Nero, TL

YearTitleAuthor(s)
2012 PEGylation of a proprotein convertase peptide inhibitor for vaginal route of drug delivery: In vitro bioactivity, stability and in vivo pharmacokinetics
Peptides
Ho, HT Nero, TL Singh, H Parker, MW Nie, GY
2012 The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling
Immunological Reviews
Broughton, SE Dhagat, U Hercus, TR Nero, TL Grimbaldeston, MA Bonder, CS Lopez, AF Parker, MW
2013 Small Molecule Proprotein Convertase Inhibitors for Inhibition of Embryo Implantation
Plos One
Ho, HT Singh, H Heng, S Nero, TL Paule, S Parker, MW Johnson, AT Jiao, GS Nie, GY
2013 Signalling by the beta c family of cytokines
Cytokine & Growth Factor Reviews
Hercus, TR Dhagat, U Kan, WLT Broughton, SE Nero, TL Perugini, M Sandow, JJ D’Andrea, RJ Ekert, PG Hughes, T Parker, MW Lopez, AF
2013 Characterization of pathogenic human monoclonal autoantibodies against GM-CSF
Proceedings Of The National Academy Of Sciences Of The United States Of America
Wang, YN Thomson, CA Allan, LL Jackson, LM Olson, M Hercus, TR Nero, TL Turner, A Parker, MW Lopez, AL Waddell, TK Anderson, GP Hamilton, JA Schrader, JW
2013 Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription
Blood
Thomas, D Powell, JA Vergez, F Segal, DH Nguyen, NYN Baker, A Teh, TC Barry, EF Sarry, JE Lee, EM Nero, TL Jabbour, AM Pomilio, G Green, BD Manenti, S Glaser, SP Parker, MW Lopez, AF Ekert, PG Lock, RB Huang, DCS Nilsson, SK Recher, C Wei, AH Guthridge, MA
2014 Crystallisation and preliminary X-ray diffraction analysis of the Interleukin-3 alpha receptor bound to Fab fragment of antibody
Acta Crystallogr F Struct Biol Commun.
Hercus, TR Fabri, LJ Broughton, SE Hardy, MP Lopez, AF Owczarek, CM Wilson, NJ Dhagat, U Nash, AD Nero, TL Scotney, PD Parker, MW
2014 Oncogenic protein interfaces: small molecules, big challenges
Nature Reviews Cancer
Nero, TL Morton, CJ Holien, JK Wielens, J Parker, MW
2014 Activity-Modulating Monoclonal Antibodies to the Human Serine Protease HtrA3 Provide Novel Insights into Regulating HtrA Proteol
Plos One
Singh, H Nero, TL Wang, Y Parker, MW Nie, GY
2014 Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
Scientific Reports
Ascher, DB Wielens, J Nero, TL Doughty, L Morton, CJ Parker, MW
2014 Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362
Acta Crystallographica Section F-structural Biology And Crystallization Communications
Broughton, SE Hercus, TR Nero, TL Dhagat, U Owczarek, CM Hardy, MP Fabri, LJ Scotney, PD Nash, AD Wilson, NJ Lopez, AF Parker, MW
2014 Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of anti
Acta Crystallographica Section F-structural Biology Communications
Broughton, SE Hercus, TR Nero, TL Dhagat, U Owczarek, CM Hardy, MP Fabri, LJ Scotney, PD Nash, AD Wilson, NJ Lopez, AF Parker, MW
2015 Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators
Journal Of Experimental Medicine
Flierl, U Nero, TL Lim, B Arthur, JF Yao, Y Jung, SM Gitz, E Pollitt, AY Zaldivia, MTK Jandrot-Perrus, M Schafer, A Nieswandt, B Andrews, RK Parker, MW Gardiner, EE Peter, K
2015 The beta c receptor family - Structural insights and their functional implications
Cytokine
Broughton, SE Nero, TL Dhagat, U Kan, WL Hercus, TR Tvorogov, D Lopez, AF Parker, MW
2015 Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9
Bioorganic & Medicinal Chemistry
Phillipson, LJ Segal, DH Nero, TL Parker, MW Wan, SS de Silva, M Guthridge, MA Wei, AH Burns, CJ
2016 Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling
Structure
Broughton, SE Hercus, TR Nero, TL Dottore, M McClure, BJ Dhagat, U Taing, H Gorman, MA King-Scott, J Lopez, AF Parker, MW
2017 Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites
Nat. Commun.
Braig, D Nero, TL Koch, HG Kaiser, B Wang, XW Thiele, JR Morton, CJ Zeller, J Kiefer, J Potempa, LA Mellett, NA Miles, LA Du, XJ Meikle, PJ Huber-Lang, M Stark, GB Parker, MW Peter, K Eisenhardt, SU
2018 Protein structure and computational drug discovery
Biochem. Soc. Trans.
Nero, TL Parker, MW Morton, CJ
2018 Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: comment
J. Thromb. Haemost.
Flierl, U Nero, TL Lim, B Andrews, RK Parker, MW Gardiner, EE Peter, K
2018 A dual role for the N-terminal domain of the IL-3 receptor in cell signalling
Nat. Commun.
Broughton, SE Hercus, TR Nero, TL Kan, WL Barry, EF Dottore, M Shing, KSCT Morton, CJ Dhagat, U Hardy, MP Wilson, NJ Downton, MT Schieber, C Hughes, TP Lopez, AF Parker, MW
2018 EPO does not promote interaction between the erythropoietin and beta-common receptors
Sci Rep
Shing, KSCT Broughton, SE Nero, TL Gillinder, K Ilsley, MD Ramshaw, H Lopez, AF Griffin, MDW Parker, MW Perkins, AC Dhagat, U
2018 The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities
Mabs
Dhagat, U Hercus, TR Broughton, SE Nero, TL Shing, KSCT Barry, EF Thomson, CA Bryson, S Pai, EF McClure, BJ Schrader, JW Lopez, AF Parker, MW
2018 Role of the beta Common (beta c) Family of Cytokines in Health and Disease
Cold Spring Harbor Perspect. Biol.
Hercus, TR Kan, WLT Broughton, SE Tvorogov, D Ramshaw, HS Sandow, JJ Nero, TL Dhagat, U Thompson, EJ Shing, KSCT McKenzie, DR Wilson, NJ Owczarek, CM Vairo, G Nash, AD Tergaonkar, V Hughes, T Ekert, PG Samuel, MS Bonder, CS Grimbaldeston, MA Parker, MW Lopez, AF