Publications by Researcher: Nero, TL

YearTitleAuthor(s)
2012 PEGylation of a proprotein convertase peptide inhibitor for vaginal route of drug delivery: In vitro bioactivity, stability and in vivo pharmacokinetics
Peptides
Ho, HT Nero, TL Singh, H Parker, MW Nie, GY
2012 The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling
Immunological Reviews
Broughton, SE Dhagat, U Hercus, TR Nero, TL Grimbaldeston, MA Bonder, CS Lopez, AF Parker, MW
2013 Small Molecule Proprotein Convertase Inhibitors for Inhibition of Embryo Implantation
Plos One
Ho, HT Singh, H Heng, S Nero, TL Paule, S Parker, MW Johnson, AT Jiao, GS Nie, GY
2013 Signalling by the beta c family of cytokines
Cytokine & Growth Factor Reviews
Hercus, TR Dhagat, U Kan, WLT Broughton, SE Nero, TL Perugini, M Sandow, JJ D’Andrea, RJ Ekert, PG Hughes, T Parker, MW Lopez, AF
2013 Characterization of pathogenic human monoclonal autoantibodies against GM-CSF
Proceedings Of The National Academy Of Sciences Of The United States Of America
Wang, YN Thomson, CA Allan, LL Jackson, LM Olson, M Hercus, TR Nero, TL Turner, A Parker, MW Lopez, AL Waddell, TK Anderson, GP Hamilton, JA Schrader, JW
2013 Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription
Blood
Thomas, D Powell, JA Vergez, F Segal, DH Nguyen, NYN Baker, A Teh, TC Barry, EF Sarry, JE Lee, EM Nero, TL Jabbour, AM Pomilio, G Green, BD Manenti, S Glaser, SP Parker, MW Lopez, AF Ekert, PG Lock, RB Huang, DCS Nilsson, SK Recher, C Wei, AH Guthridge, MA
2014 Crystallisation and preliminary X-ray diffraction analysis of the Interleukin-3 alpha receptor bound to Fab fragment of antibody
Acta Crystallogr F Struct Biol Commun.
Wilson, NJ Dhagat, U Nash, AD Nero, TL Scotney, PD Hercus, TR Fabri, LJ Broughton, SE Hardy, MP Lopez, AF Owczarek, CM Parker, MW
2014 Oncogenic protein interfaces: small molecules, big challenges
Nature Reviews Cancer
Nero, TL Morton, CJ Holien, JK Wielens, J Parker, MW
2014 Activity-Modulating Monoclonal Antibodies to the Human Serine Protease HtrA3 Provide Novel Insights into Regulating HtrA Proteol
Plos One
Singh, H Nero, TL Wang, Y Parker, MW Nie, GY
2014 Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362
Acta Crystallographica Section F-structural Biology And Crystallization Communications
Broughton, SE Hercus, TR Nero, TL Dhagat, U Owczarek, CM Hardy, MP Fabri, LJ Scotney, PD Nash, AD Wilson, NJ Lopez, AF Parker, MW
2014 Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of anti
Acta Crystallographica Section F-structural Biology Communications
Broughton, SE Hercus, TR Nero, TL Dhagat, U Owczarek, CM Hardy, MP Fabri, LJ Scotney, PD Nash, AD Wilson, NJ Lopez, AF Parker, MW
2014 Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
Scientific Reports
Ascher, DB Wielens, J Nero, TL Doughty, L Morton, CJ Parker, MW
2015 Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators
Journal Of Experimental Medicine
Flierl, U Nero, TL Lim, B Arthur, JF Yao, Y Jung, SM Gitz, E Pollitt, AY Zaldivia, MTK Jandrot-Perrus, M Schafer, A Nieswandt, B Andrews, RK Parker, MW Gardiner, EE Peter, K
2015 The beta c receptor family - Structural insights and their functional implications
Cytokine
Broughton, SE Nero, TL Dhagat, U Kan, WL Hercus, TR Tvorogov, D Lopez, AF Parker, MW
2015 Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9
Bioorganic & Medicinal Chemistry
Phillipson, LJ Segal, DH Nero, TL Parker, MW Wan, SS de Silva, M Guthridge, MA Wei, AH Burns, CJ
2016 Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling
Structure
Broughton, SE Hercus, TR Nero, TL Dottore, M McClure, BJ Dhagat, U Taing, H Gorman, MA King-Scott, J Lopez, AF Parker, MW
2017 Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites
Nat. Commun.
Braig, D Nero, TL Koch, HG Kaiser, B Wang, XW Thiele, JR Morton, CJ Zeller, J Kiefer, J Potempa, LA Mellett, NA Miles, LA Du, XJ Meikle, PJ Huber-Lang, M Stark, GB Parker, MW Peter, K Eisenhardt, SU
2018 Protein structure and computational drug discovery
Biochem. Soc. Trans.
Nero, TL Parker, MW Morton, CJ
2018 Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: comment
J. Thromb. Haemost.
Flierl, U Nero, TL Lim, B Andrews, RK Parker, MW Gardiner, EE Peter, K
2018 EPO does not promote interaction between the erythropoietin and beta-common receptors
Sci Rep
Shing, KSCT Broughton, SE Nero, TL Gillinder, K Ilsley, MD Ramshaw, H Lopez, AF Griffin, MDW Parker, MW Perkins, AC Dhagat, U
2018 A dual role for the N-terminal domain of the IL-3 receptor in cell signalling
Nat. Commun.
Broughton, SE Hercus, TR Nero, TL Kan, WL Barry, EF Dottore, M Shing, KSCT Morton, CJ Dhagat, U Hardy, MP Wilson, NJ Downton, MT Schieber, C Hughes, TP Lopez, AF Parker, MW
2018 The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities
Mabs
Dhagat, U Hercus, TR Broughton, SE Nero, TL Shing, KSCT Barry, EF Thomson, CA Bryson, S Pai, EF McClure, BJ Schrader, JW Lopez, AF Parker, MW
2018 Role of the beta Common (beta c) Family of Cytokines in Health and Disease
Cold Spring Harbor Perspect. Biol.
Hercus, TR Kan, WLT Broughton, SE Tvorogov, D Ramshaw, HS Sandow, JJ Nero, TL Dhagat, U Thompson, EJ Shing, KSCT McKenzie, DR Wilson, NJ Owczarek, CM Vairo, G Nash, AD Tergaonkar, V Hughes, T Ekert, PG Samuel, MS Bonder, CS Grimbaldeston, MA Parker, MW Lopez, AF
2019 EPO does not promote interaction between the erythropoietin and beta-common receptors (vol 8, 12457, 2018)
Scientific Reports
Shing, KSCT Broughton, SE Nero, TL Gillinder, K Ilsley, MD Ramshaw, H Lopez, AF Griffin, MDW Parker, MW Perkins, AC Dhagat, U
2019 A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites
Cell Host & Microbe
Sernee, MF Ralton, JE Nero, TL Sobala, LF Kloehn, J Vieira-Lara, MA Cobbold, SA Stanton, L Pires, DEV Hanssen, E Males, A Ward, T Bastidas, LM van der Peet, PL Parker, MW Ascher, DB Williams, SJ Davies, GJ McConville, MJ
2019 Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth
Embo Molecular Medicine
Thilakasiri, P Huynh, J Poh, AR Tan, CW Nero, TL Tran, K Parslow, AC Afshar-Sterle, S Baloyan, D Hannan, NJ Buchert, M Scott, AM Griffin, MDW Hollande, F Parker, MW Putoczki, TL Ernst, M Chand, AL
2019 Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis
Iscience
Miles, LA Hermans, SJ Crespi, GAN Gooi, JH Doughty, L Nero, TL Markulic, J Ebneth, A Wroblowski, B Oehlrich, D Trabanco, AA Rives, ML Royaux, I Hancock, NC Parker, MW
2020 Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK beta 1 isoforms
Nature Metabolism
Pinkosky, SL Scott, JW Desjardins, EM Smith, BK Day, EA Ford, RJ Langendorf, CG Ling, NXY Nero, TL Loh, K Galic, S Hoque, A Smiles, WJ Ngoei, KRW Parker, MW Yan, Y Melcher, K Kemp, BE Oakhill, JS Steinberg, GR
2021 Repurposing of drugs as STAT3 inhibitors for cancer therapy
Seminars In Cancer Biology
Thilakasiri, PS Dmello, RS Nero, TL Parker, MW Ernst, M Chand, AL