Publications by Researcher: Scott, JW

Year	Title	Author(s)
2012	AMPK functions as an adenylate charge-regulated protein kinase Trends In Endocrinology And Metabolism	Oakhill, JS Scott, JW Kemp, BE
2014	Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling Chemistry & Biology	Scott, JW Ling, NM Issa, SMA Dite, TA O’Brien, MT Chen, ZP Galic, S Langendorf, CG Steinberg, GR Kemp, BE Oakhill, JS
2014	ATP sensitive bi-quinoline activator of the AMP-activated protein kinase Biochemical And Biophysical Research Communications	Scott, JW Oakhill, JS Ling, NXY Langendorf, CG Foitzik, RC Kemp, BE Issinger, OG
2014	Mutant TDP-43 Deregulates AMPK Activation by PP2A in ALS Models Plos One	Perera, ND Sheean, RK Scott, JW Kemp, BE Horne, MK Turner, BJ
2015	Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release Chem Biol	Ling, NXY Thomas, HE Foitzik, R Weng, QP Kemp, BE Graham, KL Langendorf, CG Steinberg, GR Galic, S Issa, SMA Birnberg, NC Scott, JW Dite, TA Kay, TW Oakhill, JS
2015	Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release Chem. Biol.	Scott, JW Galic, S Graham, KL Foitzik, R Ling, NXY Dite, TA Issa, SMA Langendorf, CG Weng, QP Thomas, HE Kay, TW Birnberg, NC Steinberg, GR Kemp, BE Oakhill, JS
2015	Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder Sci Rep	Scott, JW Park, E Rodriguiz, RM Oakhill, JS Issa, SMA O’Brien, MT Dite, TA Langendorf, CG Wetsel, WC Means, AR Kemp, BE
2015	Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity Biochem. J.	Ford, RJ Fullerton, MD Pinkosky, SL Day, EA Scott, JW Oakhill, JS Bujak, AL Smith, BK Crane, JD Blumer, RM Marcinko, K Kemp, BE Gerstein, HC Steinberg, GR
2015	SnRK1 from Arabidopsis thaliana is an atypical AMPK Plant Journal	Emanuelle, S Hossain, MI Moller, IE Pedersen, HL van de Meene, AML Doblin, MS Koay, A Oakhill, JS Scott, JW Willats, WGT Kemp, BE Bacic, A Gooley, PR Stapleton, DI
2016	Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding Nat. Commun.	Langendorf, CG Ngoei, KRW Scott, JW Ling, NXY Issa, SMA Gorman, MA Parker, MW Sakamoto, K Oakhill, JS Kemp, BE
2016	beta-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase Sci Rep	Ali, N Ling, NM Krishnamurthy, S Oakhill, JS Scott, JW Stapleton, DI Kemp, BE Anand, GS Gooley, PR
2017	The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs Nat. Commun.	Dite, TA Ling, NXY Scott, JW Hoque, A Galic, S Parker, BL Ngoei, KRW Langendorf, CG O’Brien, MT Kundu, M Viollet, B Steinberg, GR Sakamoto, K Kemp, BE Oakhill, JS
2017	Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation Sci Rep	O’Brien, MT Oakhill, JS Ling, NMXY Langendorf, CG Hoque, A Dite, TA Means, AR Kemp, BE Scott, JW
2018	Transient Expression of AMPK Heterotrimer Complexes in Mammalian Cells Methods Mol. Biol.	Oakhill, JS Scott, JW Dite, TA
2018	1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors Molecules	Asquith, CRM Godoi, PH Counago, RM Laitinen, T Scott, JW Langendorf, CG Oakhill, JS Drewry, DH Zuercher, WJ Koutentis, PA Willson, TM Kalogirou, AS
2018	Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells Cell Death Discov.	Hogue, A Sivakumaran, P Bond, ST Ling, NXY Kong, AM Scott, JW Bandara, N Hernandez, D Liu, GS Wong, RCB Ryan, MT Hausenloy, DJ Kemp, BE Oakhill, JS Drew, BG Pebay, A Lim, SY
2018	AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965 J. Biol. Chem.	Dite, TA Langendorf, CG Hoque, A Galic, S Rebello, RJ Ovens, AJ Lindqvist, LM Ngoei, KRW Ling, NXY Furic, L Kemp, BE Scott, JW Oakhill, JS
2018	Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4 Cell Chem. Biol.	Ngoei, KRW Langendorf, CG Ling, NXY Hoque, A Varghese, S Camerino, MA Walker, SR Bozikis, YE Dite, TA Ovens, AJ Smiles, WJ Jacobs, R Huang, H Parker, MW Scott, JW Rider, MH Foitzik, RC Kemp, BE Baell, JB Oakhill, JS
2019	Allosteric regulation of AMP-activated protein kinase by adenylate nucleotides and small-molecule drugs Biochemical Society Transactions	Matos, ALDA Oakhill, JS Moreira, J Loh, K Galic, S Scott, JW
2019	Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance Hepatol. Commun.	Loh, K Tam, S Murray-Segal, L Huynh, K Meikle, PJ Scott, JW van Denderen, B Chen, ZP Steel, R LeBlond, ND Burkovsky, LA O’Dwyer, C Nunes, JRC Steinberg, GR Fullerton, MD Galic, S Kemp, BE
2019	AMP-activated protein kinase complexes containing the beta 2 regulatory subunit are up-regulated during and contribute to adipogenesis Biochemical Journal	Katwan, OJ Aighamdi, F Almabrouk, TA Mancini, SJ Kennedy, S Oakhill, JS Scott, JW Salt, IP
2020	In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds Molecules	O’Byrne, SN Scott, JW Pilotte, JR Santiago, AD Langendorf, CG Oakhill, JS Eduful, BJ Counago, RM Wells, CI Zuercher, WJ Willson, TM Drewry, DH
2020	Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK beta 1 isoforms Nature Metabolism	Pinkosky, SL Scott, JW Desjardins, EM Smith, BK Day, EA Ford, RJ Langendorf, CG Ling, NXY Nero, TL Loh, K Galic, S Hoque, A Smiles, WJ Ngoei, KRW Parker, MW Yan, Y Melcher, K Kemp, BE Oakhill, JS Steinberg, GR
2020	New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology Pharmacology & Therapeutics	Rosdah, AA Smiles, WJ Oakhill, JS Scott, JW Langendorf, CG Delbridge, LMD Holien, JK Lim, SY
2020	Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495 Biochemical Journal	Spengler, K Zibrova, D Woods, A Langendorf, CG Scott, JW Carling, D Heller, R
2020	Functional analysis of an R311C variant of Ca2+-calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder Bipolar Disorders	Ling, NXY Langendorf, CG Hoque, A Galic, S Loh, K Kemp, BE Gundlach, AL Oakhill, JS Scott, JW
2020	Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism Molecular Metabolism	Hoffman, NJ Whitfield, J Janzen, NR Belhaj, MR Galic, S Murray-Segal, L Smiles, WJ Ling, NXY Dite, TA Scott, JW Oakhill, JS Brink, R Kemp, BE Hawley, JA
2020	mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress Nature Metabolism	Ling, NXY Kaczmarek, A Hoque, A Davie, E Ngoei, KRW Morrison, KR Smiles, WJ Forte, GM Wang, TT Lie, S Dite, TA Langendorf, CG Scott, JW Oakhill, JS Petersen, J
2020	CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins Journal Of Biological Chemistry	Langendorf, CG O’Brien, MT Ngoei, KRW McAloon, LM Dhagat, U Hoque, A Ling, NXY Dite, TA Galic, S Loh, K Parker, MW Oakhill, JS Kemp, BE Scott, JW
2021	Post-Translational Modifications of the Energy Guardian AMP-Activated Protein Kinase International Journal Of Molecular Sciences	Ovens, AJ Scott, JW Langendorf, CG Kemp, BE Oakhill, JS Smiles, WJ
2021	Regulation of Pancreatic beta-Cell Function by the NPY System Endocrinology	Yang, CH Onda, DA Oakhill, JS Scott, JW Galic, S Loh, K
2021	Molecular Mechanisms Underlying the Beneficial Effects of Exercise on Brain Function and Neurological Disorders International Journal Of Molecular Sciences	Nay, K Smiles, WJ Kaiser, J McAloon, LM Loh, K Galic, S Oakhill, JS Gundlach, AL Scott, JW
2021	Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965 Biochemical Journal	Ahwazi, D Neopane, K Markby, GR Kopietz, F Ovens, AJ Dall, M Hassing, AS Graesle, P Alshuweishi, Y Treebak, JT Salt, IP Goransson, O Zeqiraj, E Scott, JW Sakamoto, K
2021	Compound- and fiber type-selective requirement of AMPKy3 for insulin-independent glucose uptake in skeletal muscle Molecular Metabolism	Rhein, P Desjardins, EM Rong, P Ahwazi, D Bonhoure, N Stolte, J Santos, MD Ovens, AJ Ehrlich, AM Garcia, JLS Ouyang, Q Yabut, JM Membrez, M Kjolby, M Jessen, N Oakhill, JS Treebak, JT Maire, P Scott, JW Sanders, MJ Descombes, P Chen, S Steinberg, GR Sakamoto, K
2021	Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes Journal Of Medicinal Chemistry	Eduful, BJ O’Byrne, SN Temme, L Asquith, CRM Liang, Y Picado, A Pilotte, JR Hossain, MA Wells, CI Zuercher, WJ Catta-Preta, CMC Ramos, PZ Santiago, AD Counago, RM Langendorf, CG Nay, K Oakhill, JS Pulliam, TL Lin, C Awad, D Willson, TM Frigo, DE Scott, JW Drewry, DH
2022	Neuropeptide Y1 receptor antagonism protects beta-cells and improves glycemic control in type 2 diabetes Molecular Metabolism	Yang, CH Ann-Onda, D Lin, XZ Fynch, S Nadarajah, S Pappas, EG Liu, X Scott, JW Oakhill, JS Galic, S Shi, YC Moreno-Asso, A Smith, C Loudovaris, T Levinger, I Eizirik, DL Laybutt, DR Herzog, H Thomas, HE Loh, K
2022	An AMPKa2-specific phospho-switch controls lysosomal targeting for activation Cell Reports	Morrison, KR Smiles, WJ Ling, NXY Hoque, A Shea, G Ngoei, KRW Yu, DY Murray-Segal, L Scott, JW Galic, S Kemp, BE Petersen, J Oakhill, JS