Publications by Researcher: Thomas, HE

Year	Title	Author(s)
2012	Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression European Journal Of Immunology	Graham, KL Krishnamurthy, B Fynch, S Ayala-Perez, R Slattery, RM Santamaria, P Thomas, HE Kay, TWH
2012	Granzyme B Is Dispensable in the Development of Diabetes in Non-Obese Diabetic Mice Plos One	Mollah, ZU Graham, KL Krishnamurthy, B Trivedi, P Brodnicki, TC Trapani, JA Kay, TW Thomas, HE
2012	Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors International Immunology	Joffe, M Necula, AS Chand, R McWhinney, BC Krishnamurthy, B Loudovaris, T Goodman, D Thomas, HE Kay, TWH Mannering, SI
2012	An indirect role for NK cells in a CD4(+) T-cell-dependent mouse model of type I diabetes Immunology And Cell Biology	Angstetra, E Graham, KL Zhao, YX Irvin, AE Elkerbout, L Santamaria, P Slattery, RM Kay, TW Thomas, HE
2012	Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells Diabetes	Krishnamurthy, B Chee, J Jhala, G Fynch, S Graham, KL Santamaria, P Morahan, G Allison, J Izon, D Thomas, HE Kay, TWH
2012	Expression of Pro- and Antiapoptotic Molecules of the Bcl-2 Family in Human Islets Postisolation Cell Transplantation	Campbell, PD Weinberg, A Chee, J Mariana, L Ayala, R Hawthorne, WJ O’Connell, PJ Loudovaris, T Cowley, MJ Kay, TW Grey, ST Thomas, HE
2013	Proinflammatory cytokines contribute to development and function of regulatory T cells in type 1 diabetes Translational Immunology In Asia-oceania	Thomas, HE Graham, KL Chee, J Thomas, R Kay, TW Krishnamurthy, B
2013	The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin-Induced Diabetes in Mice Diabetes	Chia, JSJ McRae, JL Thomas, HE Fynch, S Elkerbout, L Hill, P Murray-Segal, L Robson, SC Chen, JF d’Apice, AJF Cowan, PJ Dwyer, KM
2013	Multicenter Australian Trial of Islet Transplantation: Improving Accessibility and Outcomes American Journal Of Transplantation	O’Connell, PJ Holmes-Walker, DJ Goodman, D Hawthorne, WJ Loudovaris, T Gunton, JE Thomas, HE Grey, ST Drogemuller, CJ Ward, GM Torpy, DJ Coates, PT Kay, TW
2013	Hypoxia-Inducible Factor-la (HIF-l alpha) Potentiates beta-Cell Survival After Islet Transplantation of Human and Mouse Islets Cell Transplantation	Stokes, RA Cheng, K Deters, N Lau, SM Hawthorne, WJ O’Connell, PJ Stolp, J Grey, S Loudovaris, T Kay, TW Thomas, HE Gonzalez, FJ Gunton, JE
2014	Glycaemic control in diabetes is restored by therapeutic manipulation of cytokines that regulated beta cell stress Nat Med	Loudovaris, T Prins, JB Tong, H Chen, AC Forbes, JM Harbourt, BE Wang, R Whitehead, JP Borg, DJ Das, I Thomas, HE Hasnain, SZ Ng, CP Kay, TW Sheng, YH McGuckin, MA
2014	Functional cytotoxic T lymphocytes against IGRP(206-214) predict diabetes in the non-obese diabetic mouse Immunology And Cell Biology	Ko, HJ Chee, J Sutherland, RM Thomas, HE Zhan, YF Krishnamurthy, B Kay, TWH Lew, AM
2014	Activation of the NLRP3 Inflammasome Complex is Not Required for Stress-Induced Death of Pancreatic Islets Plos One	Wali, JA Gurzov, EN Fynch, S Elkerbout, L Kay, TW Masters, SL Thomas, HE
2014	Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes Journal Of Immunology	Chee, J Ko, HJ Skowera, A Jhala, G Catterall, T Graham, KL Sutherland, RM Thomas, HE Lew, AM Peakman, M Kay, TWH Krishnamurthy, B
2014	Deficiency in Type I Interferon Signaling Prevents the Early Interferon-Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice Diabetes	Quah, HS Miranda-Hernandez, S Khoo, A Harding, A Fynch, S Elkerbout, L Brodnicki, TC Baxter, AG Kay, TWH Thomas, HE Graham, KL
2014	The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity Cell Death & Disease	Wali, JA Rondas, D McKenzie, MD Zhao, Y Elkerbout, L Fynch, S Gurzov, EN Akira, S Mathieu, C Kay, TWH Overbergh, L Strasser, A Thomas, HE
2015	Localisation of dipeptidyl peptidase-4 (CD26) to human pancreatic ducts and islet alpha cells Diabetes Res Clin Pract.	Hawthorne, WJ Thomas, HE Loudovaris, T Heinke, P Naselli, G Rogers, K Augstein, P Bandala-Sanchez, E Campbell, P Kay, TW Harrison, LC
2015	Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release Chem Biol	Thomas, HE Foitzik, R Weng, QP Kemp, BE Graham, KL Langendorf, CG Steinberg, GR Galic, S Issa, SMA Birnberg, NC Scott, JW Dite, TA Kay, TW Ling, NXY Oakhill, JS
2015	Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes Clin Transl Immunology	Mehdi, AM Irvine, KM Pang, D Hamilton-Williams, EE Harris, M Thomas, HE Thomas, R
2015	Protein tyrosine phosphatases: molecular switches in metabolism and diabetes Trends In Endocrinology And Metabolism	Gurzov, EN Stanley, WJ Brodnicki, TC Thomas, HE
2015	A comparative analysis of high-throughput platforms for validation of a circulating microRNA signature in diabetic retinopathy Sci Rep	Farr, RJ Januszewski, AS Joglekar, MV Liang, H McAulley, AK Hewitt, AW Thomas, HE Loudovaris, T Kay, TWH Jenkins, A Hardikar, AA
2015	Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets Diabetes	Stanley, WJ Litwak, SA Quah, HS Tan, SM Kay, TWH Tiganis, T de Haan, JB Thomas, HE Gurzov, EN
2015	Lipotoxic Stress Induces Pancreatic beta-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System Journal Of Diabetes Research	Litwak, SA Wali, JA Pappas, EG Saadi, H Stanley, WJ Varanasi, LC Kay, TWH Thomas, HE Gurzov, EN
2015	Localization of dipeptidyl peptidase-4 (CD26) to human pancreatic ducts and islet alpha cells Diabetes Res. Clin. Pract.	Augstein, P Naselli, G Loudovaris, T Hawthorne, WJ Campbell, P Bandala-Sanchez, E Rogers, K Heinke, P Thomas, HE Kay, TW Harrison, LC
2015	Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate Eur. J. Immunol.	Zhao, YX Scott, NA Quah, HS Krishnamurthy, B Bond, F Loudovaris, T Mannering, SI Kay, TWH Thomas, HE
2015	Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release Chem. Biol.	Scott, JW Galic, S Graham, KL Foitzik, R Ling, NXY Dite, TA Issa, SMA Langendorf, CG Weng, QP Thomas, HE Kay, TW Birnberg, NC Steinberg, GR Kemp, BE Oakhill, JS
2015	Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes Diabetologia	Zhao, YX Scott, NA Fynch, S Elkerbout, L Wong, WWL Mason, KD Strasser, A Huang, DC Kay, TWH Thomas, HE
2015	Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer-Restricted CD4(+) T Cells Infiltrate Islets in Type 1 Diabetes Diabetes	Pathiraja, V Kuehlich, JP Campbell, PD Krishnamurthy, B Loudovaris, T Coates, PTH Brodnicki, TC O’Connell, PJ Kedzierska, K Rodda, C Bergman, P Hill, E Purcell, AW Dudek, NL Thomas, HE Kay, TWH Mannering, SI
2015	BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells Diabetes	Krishnamurthy, B Chee, J Jhala, G Trivedi, P Catterall, T Selck, C Gurzov, EN Brodnicki, TC Graham, KL Wali, JA Zhan, YF Gray, D Strasser, A Allison, J Thomas, HE Kay, TWH
2016	Regenerative Medicine: Clinical Islet Transplantation Stem Cell Biol. Regen. Med.	Thomas, HE Graham, KL Loudovaris, T Kay, TWH
2016	Genetic strategies to bring islet xenotransplantation to the clinic Curr. Opin. Organ Transpl.	Hawthorne, WJ Lew, AM Thomas, HE
2016	Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling Sci Rep	Pane, JA Fleming, FE Graham, KL Thomas, HE Kay, TWH Coulson, BS
2016	The JAK/STAT pathway in obesity and diabetes Febs J.	Gurzov, EN Stanley, WJ Pappas, EG Thomas, HE Gough, DJ
2016	Perforin facilitates beta cell killing and regulates autoreactive CD8+ T cell responses to antigen in mouse models of type 1 dia Immunol Cell Biol	Slattery, RM Fynch, S Krishnamurthy, B Graham, KL Trivedi, P Kay, TW Thomas, HE
2016	Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes Jci Insight	Jhala, G Chee, J Trivedi, PM Selck, C Gurzov, EN Graham, KL Thomas, HE Kay, TWH Krishnamurthy, B
2016	p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity. Sci Rep	Litwak, SA Loh, K Stanley, WJ Pappas, EG Wali, JA Selck, C Strasser, A Thomas, HE Gurzov, EN
2016	Human islet cells are killed by BID-independent mechanisms in response to FAS ligand Apoptosis	Joglekar, MV Trivedi, PM Kay, TW Hawthorne, WJ O’Connell, PJ Jenkins, AJ Hardikar, AA Thomas, HE
2017	Differential regulation of pro-inflammatory cytokine signalling by protein tyrosine phosphatases in pancreatic beta-cells J. Mol. Endocrinol.	Stanley, WJ Trivedi, PM Sutherland, AP Thomas, HE Gurzov, EN
2017	Transplantation sites for human and murine islets Diabetologia	Stokes, RA Cheng, K Lalwani, A Swarbrick, MM Thomas, HE Loudovaris, T Kay, TW Hawthorne, WJ O’Connell, PJ Gunton, JE
2017	Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility Mol. Immunol.	Chu, EPF Elso, CM Pollock, AH Alsayb, MA Mackin, L Thomas, HE Kay, TWH Silveira, PA Mansell, AS Gaus, K Brodnicki, TC
2017	JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity Diabetes	Litwak, SA Pang, L Galic, S Igoillo-Esteve, M Stanley, WJ Turatsinze, JV Loh, K Thomas, HE Sharma, A Trepo, E Moreno, C Gough, DJ Eizirik, DL de Haan, JB Gurzov, EN
2017	Inhibition of Y1 receptor signaling improves islet transplant outcome Nat. Commun.	Loh, K Shi, YC Walters, S Bensellam, M Lee, K Dezaki, K Nakata, M Ip, CK Chan, JY Gurzov, EN Thomas, HE Waibel, M Cantley, J Kay, TW Yada, T Laybutt, DR Grey, ST Herzog, H
2017	Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice Diabetes	Trivedi, PM Graham, KL Scott, NA Jenkins, MR Majaw, S Sutherland, RM Fynch, S Lew, AM Burns, CJ Krishnamurthy, B Brodnicki, TC Mannering, SI Kay, TW Thomas, HE
2017	Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway Diabetes	Mollah, ZUA Quah, HS Graham, KL Jhala, G Krishnamurthy, B Dharma, JFM Chee, J Trivedi, PM Pappas, EG Mackin, L Chu, EPF Akazawa, S Fynch, S Hodson, C Deans, AJ Trapani, JA Chong, MMW Bird, PI Brodnicki, TC Thomas, HE Kay, TWH
2018	Type I Interferon Signaling Is Required for Dacryoadenitis in the Nonobese Diabetic Mouse Model of Sjogren Syndrome Int. J. Mol. Sci.	Chaly, Y Barr, JY Sullivan, DA Thomas, HE Brodnicki, TC Lieberman, SM
2018	IFN gamma-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4(+) T Cell Migration Front. Immunol.	Scott, NA Zhao, YX Krishnamurthy, B Mannering, SI Kay, TWH Thomas, HE
2018	NF-kappa B is weakly activated in the NOD mouse model of type 1 diabetes Sci Rep	Irvin, AE Jhala, G Zhao, YX Blackwell, TS Krishnamurthy, B Thomas, HE Kay, TWH
2018	Expression of miR-206 in human islets and its role in glucokinase regulation Am. J. Physiol.-endocrinol. Metab.	Joglekar, MV Wong, WKM Maynard, CL Umrani, MR Martin, D Loudovaris, T Thomas, HE Dalgaard, LT Hardikar, AA
2018	Proinsulin C-peptide is an autoantigen in people with type 1 diabetes Proc. Natl. Acad. Sci. U. S. A.	So, M Elso, CM Tresoldi, E Pakusch, M Pathiraja, V Wentworth, JM Harrison, LC Krishnamurthy, B Thomas, HE Rodda, C Cameron, FJ McMahon, J Kay, TWH Mannering, SI
2018	Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans Plos One	Simeonovic, CJ Popp, SK Starrs, LM Brown, DJ Ziolkowski, AF Ludwig, B Bornstein, SR Wilson, JD Pugliese, A Kay, TWH Thomas, HE Loudovaris, T Choong, FJ Freeman, C Parish, CR
2018	Characterization of the Human Pancreas Side Population as a Potential Reservoir of Adult Stem Cells Pancreas	Augstein, P Loudovaris, T Bandala-Sanchez, E Heinke, P Naselli, G Lee, L Hawthorne, WJ Gonez, LJ Neale, AM Vaillant, F Thomas, HE Kay, TW Banakh, I Harrison, LC
2018	Oxygen-permeable microwell device maintains islet mass and integrity during shipping Endocr. Connect.	Rojas-Canales, DM Waibel, M Forget, A Penko, D Nitschke, J Harding, FJ Delalat, B Blencowe, A Loudovaris, T Grey, ST Thomas, HE Kay, TWH Drogemuller, CJ Voelcker, NH Coates, PT
2018	Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice Cell Death Differ.	Wali, JA Galic, S Tan, CYR Gurzov, EN Frazier, AE Connor, T Ge, JJ Pappas, EG Stroud, D Varanasi, LC Selck, C Ryan, MT Thorburn, DR Kemp, BE Krishnamurthy, B Kay, TWH Thomas, HE
2019	Replacing murine insulin 1 with human insulin protects NOD mice from diabetes Plos One	Elso, CM Scott, NA Mariana, L Masterman, EI Sutherland, APR Thomas, HE Mannering, SI
2019	Phlda3 regulates beta cell survival during stress Scientific Reports	Bensellam, M Chan, JY Lee, K Joglekar, MV Hardikar, AA Loudovaris, T Thomas, HE Jonas, JC Laybutt, DR
2019	Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans Diabetologia	Bensellam, M Shi, YC Chan, JY Laybutt, DR Chae, H Abou-Samra, M Pappas, EG Thomas, HE Gilon, P Jonas, JC
2019	Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice Cell Death Discovery	Trivedi, PM Fynch, S Kennedy, LM Chee, J Krishnamurthy, B O’Reilly, LA Strasser, A Kay, TWH Thomas, HE
2019	IL-21 regulates SOCS1 expression in autoreactive CD8(+) T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice Scientific Reports	Sutherland, APR Graham, KL Papadimitriou, M Jhala, G Trivedi, P Catterall, T Fynch, S Kay, TWH Thomas, HE
2019	Replica moulded poly(dimethylsiloxane) microwell arrays induce localized endothelial cell immobilization for coculture with pancreatic islets Biointerphases	Burzava, ALS Forget, A Harding, FJ Cockshell, MP Penko, D Rouzaud, C Ahmadi, V Marina, PF Rojas-Canales, D Bonder, CS Coates, PTH Waibel, M Thomas, HE Kay, TW Loudovaris, T Blencowe, A Voelcker, NH
2020	IL-17F induces inflammation, dysfunction and cell death in mouse islets Scientific Reports	Catterall, T Fynch, S Kay, TWH Thomas, HE Sutherland, APR
2020	A fluorescent timer reporter enables sorting of insulin secretory granules by age Journal Of Biological Chemistry	Yau, B Hays, L Liang, C Laybutt, DR Thomas, HE Gunton, JE Williams, L Hawthorne, WJ Thorn, P Rhodes, CJ Kebede, MA
2020	E2f8 and Dlg2 genes have independent effects on impaired insulin secretion associated with hyperglycaemia Diabetologia	Yang, CH Mangiafico, SP Waibel, M Loudovaris, T Loh, K Thomas, HE Morahan, G Andrikopoulos, S
2020	The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-gamma and Common gamma Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice Frontiers In Immunology	Ge, TT Jhala, G Fynch, S Akazawa, S Litwak, S Pappas, EG Catterall, T Vakil, I Long, AJ Olson, LM Krishnamurthy, B Kay, TW Thomas, HE
2020	ABCA12 regulates insulin secretion from beta-cells Embo Reports	Ursino, GM Fu, Y Cottle, DL Mukhamedova, N Jones, LK Low, H Tham, MS Gan, WJ Mellett, NA Das, PP Weir, JM Ditiatkovski, M Fynch, S Thorn, P Thomas, HE Meikle, PJ Parkington, HC Smyth, IM Sviridov, D
2021	Enhanced structure and function of human pluripotent stem cell-derived beta-cells cultured on extracellular matrix Stem Cells Translational Medicine	Singh, R Cottle, L Loudovaris, T Xiao, D Yang, PY Thomas, HE Kebede, MA Thorn, P
2021	Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice Frontiers In Immunology	Jhala, G Selck, C Chee, J Kwong, CTJ Pappas, EG Thomas, HE Kay, TWH Krishnamurthy, B
2021	Harnessing CD8(+) T-cell exhaustion to treat type 1 diabetes Immunology And Cell Biology	Kwong, CTJ Selck, C Tahija, K McAnaney, LJ Le, DV Kay, TWH Thomas, HE Krishnamurthy, B
2021	Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes Diabetologia	Cottle, L Gan, WJ Gilroy, I Samra, JS Gill, AJ Loudovaris, T Thomas, HE Hawthorne, WJ Kebede, MA Thorn, P
2021	Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice Diabetologia	Akazawa, S Mackin, L Jhala, G Fynch, S Catterall, T Selck, C Graham, KL Krishnamurthy, B Pappas, EG Kwong, CTJ Sutherland, APR Kay, TWH Brodnicki, TC Thomas, HE
2021	Machine learning workflows identify a microRNA signature of insulin transcription in human tissues Iscience	Wong, WKM Joglekar, MV Saini, V Jiang, GZ Dong, CX Chaitarvornkit, A Maciag, GJ Gerace, D Farr, RJ Satoor, SN Sahu, S Sharangdhar, T Ahmed, AS Chew, YV Liuwantara, D Heng, B Lim, CK Hunter, J Januszewski, AS Sorensen, AE Akil, ASA Gamble, JR Loudovaris, T Kay, TW Thomas, HE O’Connell, PJ Guillemin, GJ Martin, D Simpson, AM Hawthorne, WJ Dalgaard, LT Ma, RCW Hardikar, AA