| Year | Title | Author(s) |
|---|
| 2012 |
Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression
|
Graham, KL Krishnamurthy, B Fynch, S Ayala-Perez, R Slattery, RM Santamaria, P Thomas, HE Kay, TWH |
| 2012 |
Granzyme B Is Dispensable in the Development of Diabetes in Non-Obese Diabetic Mice
|
Mollah, ZU Graham, KL Krishnamurthy, B Trivedi, P Brodnicki, TC Trapani, JA Kay, TW Thomas, HE |
| 2012 |
Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors
|
Joffe, M Necula, AS Chand, R McWhinney, BC Krishnamurthy, B Loudovaris, T Goodman, D Thomas, HE Kay, TWH Mannering, SI |
| 2012 |
An indirect role for NK cells in a CD4(+) T-cell-dependent mouse model of type I diabetes
|
Angstetra, E Graham, KL Zhao, YX Irvin, AE Elkerbout, L Santamaria, P Slattery, RM Kay, TW Thomas, HE |
| 2012 |
Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells
|
Krishnamurthy, B Chee, J Jhala, G Fynch, S Graham, KL Santamaria, P Morahan, G Allison, J Izon, D Thomas, HE Kay, TWH |
| 2012 |
Expression of Pro- and Antiapoptotic Molecules of the Bcl-2 Family in Human Islets Postisolation
|
Campbell, PD Weinberg, A Chee, J Mariana, L Ayala, R Hawthorne, WJ O’Connell, PJ Loudovaris, T Cowley, MJ Kay, TW Grey, ST Thomas, HE |
| 2013 |
Proinflammatory cytokines contribute to development and function of regulatory T cells in type 1 diabetes
|
Thomas, HE Graham, KL Chee, J Thomas, R Kay, TW Krishnamurthy, B |
| 2013 |
The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin-Induced Diabetes in Mice
|
Chia, JSJ McRae, JL Thomas, HE Fynch, S Elkerbout, L Hill, P Murray-Segal, L Robson, SC Chen, JF d’Apice, AJF Cowan, PJ Dwyer, KM |
| 2013 |
Multicenter Australian Trial of Islet Transplantation: Improving Accessibility and Outcomes
|
O’Connell, PJ Holmes-Walker, DJ Goodman, D Hawthorne, WJ Loudovaris, T Gunton, JE Thomas, HE Grey, ST Drogemuller, CJ Ward, GM Torpy, DJ Coates, PT Kay, TW |
| 2013 |
Hypoxia-Inducible Factor-la (HIF-l alpha) Potentiates beta-Cell Survival After Islet Transplantation of Human and Mouse Islets
|
Stokes, RA Cheng, K Deters, N Lau, SM Hawthorne, WJ O’Connell, PJ Stolp, J Grey, S Loudovaris, T Kay, TW Thomas, HE Gonzalez, FJ Gunton, JE |
| 2014 |
Glycaemic control in diabetes is restored by therapeutic manipulation of cytokines that regulated beta cell stress
|
Loudovaris, T Tong, H Chen, AC Forbes, JM Harbourt, BE Wang, R Whitehead, JP Borg, DJ Das, I Thomas, HE Hasnain, SZ Ng, CP Kay, TW Prins, JB Sheng, YH McGuckin, MA |
| 2014 |
Functional cytotoxic T lymphocytes against IGRP(206-214) predict diabetes in the non-obese diabetic mouse
|
Ko, HJ Chee, J Sutherland, RM Thomas, HE Zhan, YF Krishnamurthy, B Kay, TWH Lew, AM |
| 2014 |
Activation of the NLRP3 Inflammasome Complex is Not Required for Stress-Induced Death of Pancreatic Islets
|
Wali, JA Gurzov, EN Fynch, S Elkerbout, L Kay, TW Masters, SL Thomas, HE |
| 2014 |
Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes
|
Chee, J Ko, HJ Skowera, A Jhala, G Catterall, T Graham, KL Sutherland, RM Thomas, HE Lew, AM Peakman, M Kay, TWH Krishnamurthy, B |
| 2014 |
Deficiency in Type I Interferon Signaling Prevents the Early Interferon-Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice
|
Quah, HS Miranda-Hernandez, S Khoo, A Harding, A Fynch, S Elkerbout, L Brodnicki, TC Baxter, AG Kay, TWH Thomas, HE Graham, KL |
| 2014 |
The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity
|
Wali, JA Rondas, D McKenzie, MD Zhao, Y Elkerbout, L Fynch, S Gurzov, EN Akira, S Mathieu, C Kay, TWH Overbergh, L Strasser, A Thomas, HE |
| 2015 |
Localisation of dipeptidyl peptidase-4 (CD26) to human pancreatic ducts and islet alpha cells
|
Hawthorne, WJ Thomas, HE Loudovaris, T Heinke, P Naselli, G Rogers, K Augstein, P Bandala-Sanchez, E Campbell, P Kay, TW Harrison, LC |
| 2015 |
Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release
|
Thomas, HE Foitzik, R Weng, QP Kemp, BE Graham, KL Langendorf, CG Steinberg, GR Galic, S Issa, SMA Birnberg, NC Scott, JW Dite, TA Kay, TW Ling, NXY Oakhill, JS |
| 2015 |
Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes
|
Mehdi, AM Irvine, KM Pang, D Hamilton-Williams, EE Harris, M Thomas, HE Thomas, R |
| 2015 |
Protein tyrosine phosphatases: molecular switches in metabolism and diabetes
|
Gurzov, EN Stanley, WJ Brodnicki, TC Thomas, HE |
| 2015 |
A comparative analysis of high-throughput platforms for validation of a circulating microRNA signature in diabetic retinopathy
|
Farr, RJ Januszewski, AS Joglekar, MV Liang, H McAulley, AK Hewitt, AW Thomas, HE Loudovaris, T Kay, TWH Jenkins, A Hardikar, AA |
| 2015 |
Lipotoxic Stress Induces Pancreatic beta-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System
|
Litwak, SA Wali, JA Pappas, EG Saadi, H Stanley, WJ Varanasi, LC Kay, TWH Thomas, HE Gurzov, EN |
| 2015 |
Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets
|
Stanley, WJ Litwak, SA Quah, HS Tan, SM Kay, TWH Tiganis, T de Haan, JB Thomas, HE Gurzov, EN |
| 2015 |
Localization of dipeptidyl peptidase-4 (CD26) to human pancreatic ducts and islet alpha cells
|
Augstein, P Naselli, G Loudovaris, T Hawthorne, WJ Campbell, P Bandala-Sanchez, E Rogers, K Heinke, P Thomas, HE Kay, TW Harrison, LC |
| 2015 |
Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate
|
Zhao, YX Scott, NA Quah, HS Krishnamurthy, B Bond, F Loudovaris, T Mannering, SI Kay, TWH Thomas, HE |
| 2015 |
Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release
|
Scott, JW Galic, S Graham, KL Foitzik, R Ling, NXY Dite, TA Issa, SMA Langendorf, CG Weng, QP Thomas, HE Kay, TW Birnberg, NC Steinberg, GR Kemp, BE Oakhill, JS |
| 2015 |
Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes
|
Zhao, YX Scott, NA Fynch, S Elkerbout, L Wong, WWL Mason, KD Strasser, A Huang, DC Kay, TWH Thomas, HE |
| 2015 |
Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer-Restricted CD4(+) T Cells Infiltrate Islets in Type 1 Diabetes
|
Pathiraja, V Kuehlich, JP Campbell, PD Krishnamurthy, B Loudovaris, T Coates, PTH Brodnicki, TC O’Connell, PJ Kedzierska, K Rodda, C Bergman, P Hill, E Purcell, AW Dudek, NL Thomas, HE Kay, TWH Mannering, SI |
| 2015 |
BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells
|
Krishnamurthy, B Chee, J Jhala, G Trivedi, P Catterall, T Selck, C Gurzov, EN Brodnicki, TC Graham, KL Wali, JA Zhan, YF Gray, D Strasser, A Allison, J Thomas, HE Kay, TWH |
| 2016 |
Perforin facilitates beta cell killing and regulates autoreactive CD8+ T cell responses to antigen in mouse models of type 1 dia
|
Slattery, RM Fynch, S Krishnamurthy, B Graham, KL Trivedi, P Kay, TW Thomas, HE |
| 2016 |
Human islet cells are killed by BID-independent mechanisms in response to FAS ligand
|
Joglekar, MV Trivedi, PM Kay, TW Hawthorne, WJ O’Connell, PJ Jenkins, AJ Hardikar, AA Thomas, HE |