Publications by Researcher: Thomas, HE

YearTitleAuthor(s)
2012 Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression
European Journal Of Immunology
Graham, KL Krishnamurthy, B Fynch, S Ayala-Perez, R Slattery, RM Santamaria, P Thomas, HE Kay, TWH
2012 Granzyme B Is Dispensable in the Development of Diabetes in Non-Obese Diabetic Mice
Plos One
Mollah, ZU Graham, KL Krishnamurthy, B Trivedi, P Brodnicki, TC Trapani, JA Kay, TW Thomas, HE
2012 Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors
International Immunology
Joffe, M Necula, AS Chand, R McWhinney, BC Krishnamurthy, B Loudovaris, T Goodman, D Thomas, HE Kay, TWH Mannering, SI
2012 An indirect role for NK cells in a CD4(+) T-cell-dependent mouse model of type I diabetes
Immunology And Cell Biology
Angstetra, E Graham, KL Zhao, YX Irvin, AE Elkerbout, L Santamaria, P Slattery, RM Kay, TW Thomas, HE
2012 Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells
Diabetes
Krishnamurthy, B Chee, J Jhala, G Fynch, S Graham, KL Santamaria, P Morahan, G Allison, J Izon, D Thomas, HE Kay, TWH
2012 Expression of Pro- and Antiapoptotic Molecules of the Bcl-2 Family in Human Islets Postisolation
Cell Transplantation
Campbell, PD Weinberg, A Chee, J Mariana, L Ayala, R Hawthorne, WJ O’Connell, PJ Loudovaris, T Cowley, MJ Kay, TW Grey, ST Thomas, HE
2013 Proinflammatory cytokines contribute to development and function of regulatory T cells in type 1 diabetes
Translational Immunology In Asia-oceania
Thomas, HE Graham, KL Chee, J Thomas, R Kay, TW Krishnamurthy, B
2013 The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin-Induced Diabetes in Mice
Diabetes
Chia, JSJ McRae, JL Thomas, HE Fynch, S Elkerbout, L Hill, P Murray-Segal, L Robson, SC Chen, JF d’Apice, AJF Cowan, PJ Dwyer, KM
2013 Multicenter Australian Trial of Islet Transplantation: Improving Accessibility and Outcomes
American Journal Of Transplantation
O’Connell, PJ Holmes-Walker, DJ Goodman, D Hawthorne, WJ Loudovaris, T Gunton, JE Thomas, HE Grey, ST Drogemuller, CJ Ward, GM Torpy, DJ Coates, PT Kay, TW
2013 Hypoxia-Inducible Factor-la (HIF-l alpha) Potentiates beta-Cell Survival After Islet Transplantation of Human and Mouse Islets
Cell Transplantation
Stokes, RA Cheng, K Deters, N Lau, SM Hawthorne, WJ O’Connell, PJ Stolp, J Grey, S Loudovaris, T Kay, TW Thomas, HE Gonzalez, FJ Gunton, JE
2014 Glycaemic control in diabetes is restored by therapeutic manipulation of cytokines that regulated beta cell stress
Nat Med
Loudovaris, T Prins, JB Tong, H Chen, AC Forbes, JM Harbourt, BE Wang, R Whitehead, JP Borg, DJ Das, I Thomas, HE Hasnain, SZ Ng, CP Kay, TW Sheng, YH McGuckin, MA
2014 Functional cytotoxic T lymphocytes against IGRP(206-214) predict diabetes in the non-obese diabetic mouse
Immunology And Cell Biology
Ko, HJ Chee, J Sutherland, RM Thomas, HE Zhan, YF Krishnamurthy, B Kay, TWH Lew, AM
2014 Activation of the NLRP3 Inflammasome Complex is Not Required for Stress-Induced Death of Pancreatic Islets
Plos One
Wali, JA Gurzov, EN Fynch, S Elkerbout, L Kay, TW Masters, SL Thomas, HE
2014 Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes
Journal Of Immunology
Chee, J Ko, HJ Skowera, A Jhala, G Catterall, T Graham, KL Sutherland, RM Thomas, HE Lew, AM Peakman, M Kay, TWH Krishnamurthy, B
2014 Deficiency in Type I Interferon Signaling Prevents the Early Interferon-Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice
Diabetes
Quah, HS Miranda-Hernandez, S Khoo, A Harding, A Fynch, S Elkerbout, L Brodnicki, TC Baxter, AG Kay, TWH Thomas, HE Graham, KL
2014 The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity
Cell Death & Disease
Wali, JA Rondas, D McKenzie, MD Zhao, Y Elkerbout, L Fynch, S Gurzov, EN Akira, S Mathieu, C Kay, TWH Overbergh, L Strasser, A Thomas, HE
2015 Localisation of dipeptidyl peptidase-4 (CD26) to human pancreatic ducts and islet alpha cells
Diabetes Res Clin Pract.
Hawthorne, WJ Thomas, HE Loudovaris, T Heinke, P Naselli, G Rogers, K Augstein, P Bandala-Sanchez, E Campbell, P Kay, TW Harrison, LC
2015 Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release
Chem Biol
Thomas, HE Foitzik, R Weng, QP Kemp, BE Graham, KL Langendorf, CG Steinberg, GR Galic, S Issa, SMA Birnberg, NC Scott, JW Dite, TA Kay, TW Ling, NXY Oakhill, JS
2015 Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes
Clin Transl Immunology
Mehdi, AM Irvine, KM Pang, D Hamilton-Williams, EE Harris, M Thomas, HE Thomas, R
2015 Protein tyrosine phosphatases: molecular switches in metabolism and diabetes
Trends In Endocrinology And Metabolism
Gurzov, EN Stanley, WJ Brodnicki, TC Thomas, HE
2015 A comparative analysis of high-throughput platforms for validation of a circulating microRNA signature in diabetic retinopathy
Sci Rep
Farr, RJ Januszewski, AS Joglekar, MV Liang, H McAulley, AK Hewitt, AW Thomas, HE Loudovaris, T Kay, TWH Jenkins, A Hardikar, AA
2015 Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets
Diabetes
Stanley, WJ Litwak, SA Quah, HS Tan, SM Kay, TWH Tiganis, T de Haan, JB Thomas, HE Gurzov, EN
2015 Lipotoxic Stress Induces Pancreatic beta-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System
Journal Of Diabetes Research
Litwak, SA Wali, JA Pappas, EG Saadi, H Stanley, WJ Varanasi, LC Kay, TWH Thomas, HE Gurzov, EN
2015 Localization of dipeptidyl peptidase-4 (CD26) to human pancreatic ducts and islet alpha cells
Diabetes Res. Clin. Pract.
Augstein, P Naselli, G Loudovaris, T Hawthorne, WJ Campbell, P Bandala-Sanchez, E Rogers, K Heinke, P Thomas, HE Kay, TW Harrison, LC
2015 Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate
Eur. J. Immunol.
Zhao, YX Scott, NA Quah, HS Krishnamurthy, B Bond, F Loudovaris, T Mannering, SI Kay, TWH Thomas, HE
2015 Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release
Chem. Biol.
Scott, JW Galic, S Graham, KL Foitzik, R Ling, NXY Dite, TA Issa, SMA Langendorf, CG Weng, QP Thomas, HE Kay, TW Birnberg, NC Steinberg, GR Kemp, BE Oakhill, JS
2015 Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes
Diabetologia
Zhao, YX Scott, NA Fynch, S Elkerbout, L Wong, WWL Mason, KD Strasser, A Huang, DC Kay, TWH Thomas, HE
2015 Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer-Restricted CD4(+) T Cells Infiltrate Islets in Type 1 Diabetes
Diabetes
Pathiraja, V Kuehlich, JP Campbell, PD Krishnamurthy, B Loudovaris, T Coates, PTH Brodnicki, TC O’Connell, PJ Kedzierska, K Rodda, C Bergman, P Hill, E Purcell, AW Dudek, NL Thomas, HE Kay, TWH Mannering, SI
2015 BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells
Diabetes
Krishnamurthy, B Chee, J Jhala, G Trivedi, P Catterall, T Selck, C Gurzov, EN Brodnicki, TC Graham, KL Wali, JA Zhan, YF Gray, D Strasser, A Allison, J Thomas, HE Kay, TWH
2016 Regenerative Medicine: Clinical Islet Transplantation
Stem Cell Biol. Regen. Med.
Thomas, HE Graham, KL Loudovaris, T Kay, TWH
2016 Genetic strategies to bring islet xenotransplantation to the clinic
Curr. Opin. Organ Transpl.
Hawthorne, WJ Lew, AM Thomas, HE
2016 Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling
Sci Rep
Pane, JA Fleming, FE Graham, KL Thomas, HE Kay, TWH Coulson, BS
2016 The JAK/STAT pathway in obesity and diabetes
Febs J.
Gurzov, EN Stanley, WJ Pappas, EG Thomas, HE Gough, DJ
2016 Perforin facilitates beta cell killing and regulates autoreactive CD8+ T cell responses to antigen in mouse models of type 1 dia
Immunol Cell Biol
Slattery, RM Fynch, S Krishnamurthy, B Graham, KL Trivedi, P Kay, TW Thomas, HE
2016 Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes
Jci Insight
Jhala, G Chee, J Trivedi, PM Selck, C Gurzov, EN Graham, KL Thomas, HE Kay, TWH Krishnamurthy, B
2016 p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity.
Sci Rep
Litwak, SA Loh, K Stanley, WJ Pappas, EG Wali, JA Selck, C Strasser, A Thomas, HE Gurzov, EN
2016 Human islet cells are killed by BID-independent mechanisms in response to FAS ligand
Apoptosis
Joglekar, MV Trivedi, PM Kay, TW Hawthorne, WJ O’Connell, PJ Jenkins, AJ Hardikar, AA Thomas, HE
2017 Differential regulation of pro-inflammatory cytokine signalling by protein tyrosine phosphatases in pancreatic beta-cells
J. Mol. Endocrinol.
Stanley, WJ Trivedi, PM Sutherland, AP Thomas, HE Gurzov, EN
2017 Transplantation sites for human and murine islets
Diabetologia
Stokes, RA Cheng, K Lalwani, A Swarbrick, MM Thomas, HE Loudovaris, T Kay, TW Hawthorne, WJ O’Connell, PJ Gunton, JE
2017 Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility
Mol. Immunol.
Chu, EPF Elso, CM Pollock, AH Alsayb, MA Mackin, L Thomas, HE Kay, TWH Silveira, PA Mansell, AS Gaus, K Brodnicki, TC
2017 JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity
Diabetes
Litwak, SA Pang, L Galic, S Igoillo-Esteve, M Stanley, WJ Turatsinze, JV Loh, K Thomas, HE Sharma, A Trepo, E Moreno, C Gough, DJ Eizirik, DL de Haan, JB Gurzov, EN
2017 Inhibition of Y1 receptor signaling improves islet transplant outcome
Nat. Commun.
Loh, K Shi, YC Walters, S Bensellam, M Lee, K Dezaki, K Nakata, M Ip, CK Chan, JY Gurzov, EN Thomas, HE Waibel, M Cantley, J Kay, TW Yada, T Laybutt, DR Grey, ST Herzog, H
2017 Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice
Diabetes
Trivedi, PM Graham, KL Scott, NA Jenkins, MR Majaw, S Sutherland, RM Fynch, S Lew, AM Burns, CJ Krishnamurthy, B Brodnicki, TC Mannering, SI Kay, TW Thomas, HE
2017 Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway
Diabetes
Mollah, ZUA Quah, HS Graham, KL Jhala, G Krishnamurthy, B Dharma, JFM Chee, J Trivedi, PM Pappas, EG Mackin, L Chu, EPF Akazawa, S Fynch, S Hodson, C Deans, AJ Trapani, JA Chong, MMW Bird, PI Brodnicki, TC Thomas, HE Kay, TWH
2018 Type I Interferon Signaling Is Required for Dacryoadenitis in the Nonobese Diabetic Mouse Model of Sjogren Syndrome
Int. J. Mol. Sci.
Chaly, Y Barr, JY Sullivan, DA Thomas, HE Brodnicki, TC Lieberman, SM
2018 IFN gamma-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4(+) T Cell Migration
Front. Immunol.
Scott, NA Zhao, YX Krishnamurthy, B Mannering, SI Kay, TWH Thomas, HE
2018 NF-kappa B is weakly activated in the NOD mouse model of type 1 diabetes
Sci Rep
Irvin, AE Jhala, G Zhao, YX Blackwell, TS Krishnamurthy, B Thomas, HE Kay, TWH
2018 Expression of miR-206 in human islets and its role in glucokinase regulation
Am. J. Physiol.-endocrinol. Metab.
Joglekar, MV Wong, WKM Maynard, CL Umrani, MR Martin, D Loudovaris, T Thomas, HE Dalgaard, LT Hardikar, AA
2018 Proinsulin C-peptide is an autoantigen in people with type 1 diabetes
Proc. Natl. Acad. Sci. U. S. A.
So, M Elso, CM Tresoldi, E Pakusch, M Pathiraja, V Wentworth, JM Harrison, LC Krishnamurthy, B Thomas, HE Rodda, C Cameron, FJ McMahon, J Kay, TWH Mannering, SI
2018 Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans
Plos One
Simeonovic, CJ Popp, SK Starrs, LM Brown, DJ Ziolkowski, AF Ludwig, B Bornstein, SR Wilson, JD Pugliese, A Kay, TWH Thomas, HE Loudovaris, T Choong, FJ Freeman, C Parish, CR
2018 Characterization of the Human Pancreas Side Population as a Potential Reservoir of Adult Stem Cells
Pancreas
Augstein, P Loudovaris, T Bandala-Sanchez, E Heinke, P Naselli, G Lee, L Hawthorne, WJ Gonez, LJ Neale, AM Vaillant, F Thomas, HE Kay, TW Banakh, I Harrison, LC
2018 Oxygen-permeable microwell device maintains islet mass and integrity during shipping
Endocr. Connect.
Rojas-Canales, DM Waibel, M Forget, A Penko, D Nitschke, J Harding, FJ Delalat, B Blencowe, A Loudovaris, T Grey, ST Thomas, HE Kay, TWH Drogemuller, CJ Voelcker, NH Coates, PT
2018 Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice
Cell Death Differ.
Wali, JA Galic, S Tan, CYR Gurzov, EN Frazier, AE Connor, T Ge, JJ Pappas, EG Stroud, D Varanasi, LC Selck, C Ryan, MT Thorburn, DR Kemp, BE Krishnamurthy, B Kay, TWH Thomas, HE
2019 Replacing murine insulin 1 with human insulin protects NOD mice from diabetes
Plos One
Elso, CM Scott, NA Mariana, L Masterman, EI Sutherland, APR Thomas, HE Mannering, SI
2019 Phlda3 regulates beta cell survival during stress
Scientific Reports
Bensellam, M Chan, JY Lee, K Joglekar, MV Hardikar, AA Loudovaris, T Thomas, HE Jonas, JC Laybutt, DR
2019 Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans
Diabetologia
Bensellam, M Shi, YC Chan, JY Laybutt, DR Chae, H Abou-Samra, M Pappas, EG Thomas, HE Gilon, P Jonas, JC
2019 Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice
Cell Death Discovery
Trivedi, PM Fynch, S Kennedy, LM Chee, J Krishnamurthy, B O’Reilly, LA Strasser, A Kay, TWH Thomas, HE
2019 IL-21 regulates SOCS1 expression in autoreactive CD8(+) T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice
Scientific Reports
Sutherland, APR Graham, KL Papadimitriou, M Jhala, G Trivedi, P Catterall, T Fynch, S Kay, TWH Thomas, HE
2019 Replica moulded poly(dimethylsiloxane) microwell arrays induce localized endothelial cell immobilization for coculture with pancreatic islets
Biointerphases
Burzava, ALS Forget, A Harding, FJ Cockshell, MP Penko, D Rouzaud, C Ahmadi, V Marina, PF Rojas-Canales, D Bonder, CS Coates, PTH Waibel, M Thomas, HE Kay, TW Loudovaris, T Blencowe, A Voelcker, NH
2020 IL-17F induces inflammation, dysfunction and cell death in mouse islets
Scientific Reports
Catterall, T Fynch, S Kay, TWH Thomas, HE Sutherland, APR
2020 A fluorescent timer reporter enables sorting of insulin secretory granules by age
Journal Of Biological Chemistry
Yau, B Hays, L Liang, C Laybutt, DR Thomas, HE Gunton, JE Williams, L Hawthorne, WJ Thorn, P Rhodes, CJ Kebede, MA
2020 E2f8 and Dlg2 genes have independent effects on impaired insulin secretion associated with hyperglycaemia
Diabetologia
Yang, CH Mangiafico, SP Waibel, M Loudovaris, T Loh, K Thomas, HE Morahan, G Andrikopoulos, S
2020 The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-gamma and Common gamma Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice
Frontiers In Immunology
Ge, TT Jhala, G Fynch, S Akazawa, S Litwak, S Pappas, EG Catterall, T Vakil, I Long, AJ Olson, LM Krishnamurthy, B Kay, TW Thomas, HE
2020 ABCA12 regulates insulin secretion from beta-cells
Embo Reports
Ursino, GM Fu, Y Cottle, DL Mukhamedova, N Jones, LK Low, H Tham, MS Gan, WJ Mellett, NA Das, PP Weir, JM Ditiatkovski, M Fynch, S Thorn, P Thomas, HE Meikle, PJ Parkington, HC Smyth, IM Sviridov, D
2021 Enhanced structure and function of human pluripotent stem cell-derived beta-cells cultured on extracellular matrix
Stem Cells Translational Medicine
Singh, R Cottle, L Loudovaris, T Xiao, D Yang, PY Thomas, HE Kebede, MA Thorn, P
2021 Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice
Frontiers In Immunology
Jhala, G Selck, C Chee, J Kwong, CTJ Pappas, EG Thomas, HE Kay, TWH Krishnamurthy, B
2021 Harnessing CD8(+) T-cell exhaustion to treat type 1 diabetes
Immunology And Cell Biology
Kwong, CTJ Selck, C Tahija, K McAnaney, LJ Le, DV Kay, TWH Thomas, HE Krishnamurthy, B
2021 Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes
Diabetologia
Cottle, L Gan, WJ Gilroy, I Samra, JS Gill, AJ Loudovaris, T Thomas, HE Hawthorne, WJ Kebede, MA Thorn, P
2021 Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice
Diabetologia
Akazawa, S Mackin, L Jhala, G Fynch, S Catterall, T Selck, C Graham, KL Krishnamurthy, B Pappas, EG Kwong, CTJ Sutherland, APR Kay, TWH Brodnicki, TC Thomas, HE
2021 Machine learning workflows identify a microRNA signature of insulin transcription in human tissues
Iscience
Wong, WKM Joglekar, MV Saini, V Jiang, GZ Dong, CX Chaitarvornkit, A Maciag, GJ Gerace, D Farr, RJ Satoor, SN Sahu, S Sharangdhar, T Ahmed, AS Chew, YV Liuwantara, D Heng, B Lim, CK Hunter, J Januszewski, AS Sorensen, AE Akil, ASA Gamble, JR Loudovaris, T Kay, TW Thomas, HE O’Connell, PJ Guillemin, GJ Martin, D Simpson, AM Hawthorne, WJ Dalgaard, LT Ma, RCW Hardikar, AA