Publications by Researcher: Langendorf, CG

Year	Title	Author(s)
2014	ATP sensitive bi-quinoline activator of the AMP-activated protein kinase Biochemical And Biophysical Research Communications	Scott, JW Oakhill, JS Ling, NXY Langendorf, CG Foitzik, RC Kemp, BE Issinger, OG
2014	Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling Chemistry & Biology	Scott, JW Ling, NM Issa, SMA Dite, TA O’Brien, MT Chen, ZP Galic, S Langendorf, CG Steinberg, GR Kemp, BE Oakhill, JS
2015	Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release Chem Biol	Dite, TA Kay, TW Ling, NXY Thomas, HE Foitzik, R Weng, QP Kemp, BE Graham, KL Langendorf, CG Steinberg, GR Galic, S Issa, SMA Birnberg, NC Scott, JW Oakhill, JS
2015	Choreography of AMPK activation Cell Research	Langendorf, CG Kemp, BE
2015	Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release Chem. Biol.	Scott, JW Galic, S Graham, KL Foitzik, R Ling, NXY Dite, TA Issa, SMA Langendorf, CG Weng, QP Thomas, HE Kay, TW Birnberg, NC Steinberg, GR Kemp, BE Oakhill, JS
2015	Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder Sci Rep	Scott, JW Park, E Rodriguiz, RM Oakhill, JS Issa, SMA O’Brien, MT Dite, TA Langendorf, CG Wetsel, WC Means, AR Kemp, BE
2016	Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding Nat. Commun.	Langendorf, CG Ngoei, KRW Scott, JW Ling, NXY Issa, SMA Gorman, MA Parker, MW Sakamoto, K Oakhill, JS Kemp, BE
2017	Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation Sci Rep	O’Brien, MT Oakhill, JS Ling, NMXY Langendorf, CG Hoque, A Dite, TA Means, AR Kemp, BE Scott, JW
2017	The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs Nat. Commun.	Dite, TA Ling, NXY Scott, JW Hoque, A Galic, S Parker, BL Ngoei, KRW Langendorf, CG O’Brien, MT Kundu, M Viollet, B Steinberg, GR Sakamoto, K Kemp, BE Oakhill, JS
2018	Visualizing AMPK Drug Binding Sites Through Crystallization of Full-Length Phosphorylated alpha 2 beta 1 gamma 1 Heterotrimer Methods Mol. Biol.	Langendorf, CG Oakhill, JS Kemp, BE
2018	Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4 Cell Chem. Biol.	Ngoei, KRW Langendorf, CG Ling, NXY Hoque, A Varghese, S Camerino, MA Walker, SR Bozikis, YE Dite, TA Ovens, AJ Smiles, WJ Jacobs, R Huang, H Parker, MW Scott, JW Rider, MH Foitzik, RC Kemp, BE Baell, JB Oakhill, JS
2018	AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965 J. Biol. Chem.	Dite, TA Langendorf, CG Hoque, A Galic, S Rebello, RJ Ovens, AJ Lindqvist, LM Ngoei, KRW Ling, NXY Furic, L Kemp, BE Scott, JW Oakhill, JS
2018	1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors Molecules	Asquith, CRM Godoi, PH Counago, RM Laitinen, T Scott, JW Langendorf, CG Oakhill, JS Drewry, DH Zuercher, WJ Koutentis, PA Willson, TM Kalogirou, AS
2020	CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins Journal Of Biological Chemistry	Langendorf, CG O’Brien, MT Ngoei, KRW McAloon, LM Dhagat, U Hoque, A Ling, NXY Dite, TA Galic, S Loh, K Parker, MW Oakhill, JS Kemp, BE Scott, JW
2020	Functional analysis of an R311C variant of Ca2+-calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder Bipolar Disorders	Ling, NXY Langendorf, CG Hoque, A Galic, S Loh, K Kemp, BE Gundlach, AL Oakhill, JS Scott, JW
2020	Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495 Biochemical Journal	Spengler, K Zibrova, D Woods, A Langendorf, CG Scott, JW Carling, D Heller, R
2020	New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology Pharmacology & Therapeutics	Rosdah, AA Smiles, WJ Oakhill, JS Scott, JW Langendorf, CG Delbridge, LMD Holien, JK Lim, SY
2020	In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds Molecules	O’Byrne, SN Scott, JW Pilotte, JR Santiago, AD Langendorf, CG Oakhill, JS Eduful, BJ Counago, RM Wells, CI Zuercher, WJ Willson, TM Drewry, DH
2020	Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK beta 1 isoforms Nature Metabolism	Pinkosky, SL Scott, JW Desjardins, EM Smith, BK Day, EA Ford, RJ Langendorf, CG Ling, NXY Nero, TL Loh, K Galic, S Hoque, A Smiles, WJ Ngoei, KRW Parker, MW Yan, Y Melcher, K Kemp, BE Oakhill, JS Steinberg, GR
2020	mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress Nature Metabolism	Ling, NXY Kaczmarek, A Hoque, A Davie, E Ngoei, KRW Morrison, KR Smiles, WJ Forte, GM Wang, TT Lie, S Dite, TA Langendorf, CG Scott, JW Oakhill, JS Petersen, J
2021	Post-Translational Modifications of the Energy Guardian AMP-Activated Protein Kinase International Journal Of Molecular Sciences	Ovens, AJ Scott, JW Langendorf, CG Kemp, BE Oakhill, JS Smiles, WJ
2021	Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes Journal Of Medicinal Chemistry	Eduful, BJ O’Byrne, SN Temme, L Asquith, CRM Liang, Y Picado, A Pilotte, JR Hossain, MA Wells, CI Zuercher, WJ Catta-Preta, CMC Ramos, PZ Santiago, AD Counago, RM Langendorf, CG Nay, K Oakhill, JS Pulliam, TL Lin, C Awad, D Willson, TM Frigo, DE Scott, JW Drewry, DH
2022	Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator Biochemical Journal	Ovens, AJ Gee, YS Ling, NXY Yu, DY Hardee, JP Chung, JD Ngoei, KRW Waters, NJ Hoffman, NJ Scott, JW Loh, K Spengler, K Heller, R Parker, MW Lynch, GS Huang, F Galic, S Kemp, BE Baell, JB Oakhill, JS Langendorf, CG
2023	SGC-CAMKK2-1: A Chemical Probe for CAMKK2 Cells	Wells, C Liang, Y Pulliam, TL Lin, CC Awad, D Eduful, B O’Byrne, S Hossain, MA Catta-Preta, CMC Ramos, PZ Gileadi, O Gileadi, C Counago, RM Stork, B Langendorf, CG Nay, K Oakhill, JS Mukherjee, D Racioppi, L Means, AR York, B McDonnell, DP Scott, JW Frigo, DE Drewry, DH