Publications by Researcher: Parker, MW

YearTitleAuthor(s)
2012 Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2
Acta Crystallographica Section F-structural Biology And Crystallization Communications
Ascher, DB Polekhina, G Parker, MW
2012 PEGylation of a proprotein convertase peptide inhibitor for vaginal route of drug delivery: In vitro bioactivity, stability and in vivo pharmacokinetics
Peptides
Ho, HT Nero, TL Singh, H Parker, MW Nie, GY
2012 Cytokine receptor activation at the cell surface
Current Opinion In Structural Biology
Broughton, SE Hercus, TR Lopez, AF Parker, MW
2012 Intracellular beta-Nicotinamide Adenine Dinucleotide Inhibits the Skeletal Muscle ClC-1 Chloride Channel
Journal Of Biological Chemistry
Bennetts, B Yu, YW Chen, TY Parker, MW
2012 Monomer-Monomer Interactions Propagate Structural Transitions Necessary for Pore Formation by the Cholesterol-dependent Cytolysins
Journal Of Biological Chemistry
Hotze, EM Wilson-Kubalek, E Farrand, AJ Bentsen, L Parker, MW Johnson, AE Tweten, RK
2012 TRIM16 Acts as an E3 Ubiquitin Ligase and Can Heterodimerize with Other TRIM Family Members
Plos One
Bell, JL Malyukova, A Holien, JK Koach, J Parker, MW Kavallaris, M Marshall, GM Cheung, BB
2012 Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation
Proceedings Of The National Academy Of Sciences Of The United States Of America
Quana, A Xue, J Wielens, J Smillie, KJ Anggono, V Parker, MW Cousin, MA Graham, ME Robinson, PJ
2012 Structural approaches to probing metal interaction with proteins
Journal Of Inorganic Biochemistry
Parker, LJ Ascher, DB Gao, C Miles, LA Harris, HH Parker, MW
2012 An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus
Acs Medicinal Chemistry Letters
Feil, SC Hamilton, S Krippner, GY Lin, B Luttick, A McConnell, DB Nearn, R Parker, MW Ryan, J Stanislawski, PC Tucker, SP Watson, KG Morton, CJ
2012 The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling
Immunological Reviews
Broughton, SE Dhagat, U Hercus, TR Nero, TL Grimbaldeston, MA Bonder, CS Lopez, AF Parker, MW
2012 Structure of the Lectin Regulatory Domain of the Cholesterol-Dependent Cytolysin Lectinolysin Reveals the Basis for Its Lewis Antigen Specificity
Structure
Feil, SC Lawrence, S Mulhern, TD Holien, JK Hotze, EM Farrand, S Tweten, RK Parker, MW
2012 The GM-CSF receptor family: Mechanism of activation and implications for disease
Growth Factors
Hercus, TR Broughton, SE Ekert, PG Ramshaw, HS Perugini, M Grimbaldeston, M Woodcock, JM Thomas, D Pitson, S Hughes, T D’Andrea, RJ Parker, MW Lopez, AF
2013 Molecular determinants of common gating of a ClC chloride channel
Nature Communications
Bennetts, B Parker, MW
2013 Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34
Cell Cycle
Suryadinata, R Holien, JK Yang, G Parker, MW Papaleo, E Sarcevic, B
2013 Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation
Scientific Reports
Miles, LA Crespi, GAN Doughty, L Parker, MW
2013 Small Molecule Proprotein Convertase Inhibitors for Inhibition of Embryo Implantation
Plos One
Ho, HT Singh, H Heng, S Nero, TL Paule, S Parker, MW Johnson, AT Jiao, GS Nie, GY
2013 Phosphorylation of Serine 779 in Fibroblast Growth Factor Receptor 1 and 2 by Protein Kinase C epsilon Regulates Ras/Mitogen-activated Protein Kinase Signaling and Neuronal Differentiation
Journal Of Biological Chemistry
Lonic, A Powell, JA Kong, Y Thomas, D Holien, JK Truong, N Parker, MW Guthridge, MA
2013 Lymphotoxin alpha induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor
Febs Journal
Etemadi, N Holien, JK Chau, D Dewson, G Murphy, JM Alexander, WS Parker, MW Silke, J Nachbur, U
2013 Disarming Bacterial Virulence through Chemical Inhibition of the DNA Binding Domain of an AraC-like Transcriptional Activator Protein
Journal Of Biological Chemistry
Yang, J Hocking, DM Cheng, C Dogovski, C Perugini, MA Holien, JK Parker, MW Hartland, EL Tauschek, M Robins-Browne, RM
2013 Synthetic dityrosine-linked beta-amyloid dimers form stable, soluble, neurotoxic oligomers
Chemical Science
Kok, WM Cottam, JM Ciccotosto, GD Miles, LA Karas, JA Scanlon, DB Roberts, BR Parker, MW Cappai, R Barnham, KJ Hutton, CA
2013 Parallel Screening of Low Molecular Weight Fragment Libraries: Do Differences in Methodology Affect Hit Identification?
Journal Of Biomolecular Screening
Wielens, J Headey, SJ Rhodes, DI Mulder, RJ Dolezal, O Deadman, JJ Newman, J Chalmers, DK Parker, MW Peat, TS Scanlon, MJ
2013 Characterization of pathogenic human monoclonal autoantibodies against GM-CSF
Proceedings Of The National Academy Of Sciences Of The United States Of America
Wang, YN Thomson, CA Allan, LL Jackson, LM Olson, M Hercus, TR Nero, TL Turner, A Parker, MW Lopez, AL Waddell, TK Anderson, GP Hamilton, JA Schrader, JW
2013 Signalling by the beta c family of cytokines
Cytokine & Growth Factor Reviews
Hercus, TR Dhagat, U Kan, WLT Broughton, SE Nero, TL Perugini, M Sandow, JJ D’Andrea, RJ Ekert, PG Hughes, T Parker, MW Lopez, AF
2013 From Knock-Out Phenotype to Three-Dimensional Structure of a Promising Antibiotic Target from Streptococcus pneumoniae
Plos One
Dogovski, C Gorman, MA Ketaren, NE Praszkier, J Zammit, LM Mertens, HD Bryant, G Yang, J Griffin, MDW Pearce, FG Gerrard, JA Jameson, GB Parker, MW Robins-Browne, RM Perugini, MA
2013 Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription
Blood
Thomas, D Powell, JA Vergez, F Segal, DH Nguyen, NYN Baker, A Teh, TC Barry, EF Sarry, JE Lee, EM Nero, TL Jabbour, AM Pomilio, G Green, BD Manenti, S Glaser, SP Parker, MW Lopez, AF Ekert, PG Lock, RB Huang, DCS Nilsson, SK Recher, C Wei, AH Guthridge, MA
2013 The Impact of Nitric Oxide Toxicity on the Evolution of the Glutathione Transferase Superfamily A PROPOSAL FOR AN EVOLUTIONARY DRIVING FORCE
Journal Of Biological Chemistry
Bocedi, A Fabrini, R Farrotti, A Stella, L Ketterman, AJ Pedersen, JZ Allocati, N Lau, PCK Grosse, S Eltis, LD Ruzzini, A Edwards, TE Morici, L Del Grosso, E Guidoni, L Bovi, D Lo Bello, M Federici, G Parker, MW Board, PG Ricci, G
2014 Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody.
Cell Rep
Barry, EF Busfield, SJ Wilson, NJ Hardy, MP Braley, H Hartman, D Parker, MW Hercus, TR Huynh, H Scotney, PD Dottore, M Dhagat, U Nash, AD McClure, BJ Kan, WL Owczarek, CM Broughton, SE Lopez, AF
2014 Tetraspanins as regulators of the tumour microenvironment: implications for metastasis and therapeutic strategies
British Journal Of Pharmacology
Detchokul, S Williams, ED Parker, MW Frauman, AG
2014 Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-beta
Acta Crystallographica Section F-structural Biology And Crystallization Communications
Crespi, GAN Ascher, DB Parker, MW Miles, LA
2014 Activity-Modulating Monoclonal Antibodies to the Human Serine Protease HtrA3 Provide Novel Insights into Regulating HtrA Proteol
Plos One
Singh, H Nero, TL Wang, Y Parker, MW Nie, GY
2014 Structural Studies of Streptococcus pyogenes Streptolysin O Provide Insights into the Early Steps of Membrane Penetration
Journal Of Molecular Biology
Feil, SC Ascher, DB Kuiper, MJ Tweten, RK Parker, MW
2014 Oncogenic protein interfaces: small molecules, big challenges
Nature Reviews Cancer
Nero, TL Morton, CJ Holien, JK Wielens, J Parker, MW
2014 Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
Scientific Reports
Ascher, DB Wielens, J Nero, TL Doughty, L Morton, CJ Parker, MW
2014 Synthesis, Structure-Activity Relationships and Brain Uptake of a Novel Series of Benzopyran Inhibitors of Insulin-Regulated Aminopeptidase
Journal Of Medicinal Chemistry
Mountford, SJ Albiston, AL Charman, WN Ng, L Holien, JK Parker, MW Nicolazzo, JA Thompson, PE Chai, SY
2014 The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster
Insect Biochemistry And Molecular Biology
Remnant, EJ Morton, CJ Daborn, PJ Lumb, C Yang, YT Ng, HL Parker, MW Batterham, P
2014 Do current therapeutic anti-A beta antibodies for Alzheimer's disease engage the target?
Acta Neuropathologica
Watt, AD Crespi, GAN Down, RA Ascher, DB Gunn, A Perez, KA McLean, CA Villemagne, VL Parker, MW Barnham, KJ Miles, LA
2014 Anti-A beta antibody target engagement: a response to Siemers et al.
Acta Neuropathologica
Watt, AD Crespi, GAN Down, RA Ascher, DB Gunn, A Perez, KA McLean, CA Villemagne, VL Parker, MW Barnham, KJ Miles, LA
2014 Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor
Science
Brooks, AJ Dai, W O’Mara, ML Abankwa, D Chhabra, Y Pelekanos, RA Gardon, O Tunny, KA Blucher, KM Morton, CJ Parker, MW Sierecki, E Gambin, Y Gomez, GA Alexandrov, K Wilson, IA Doxastakis, M Mark, AE Waters, MJ
2014 Crystallisation and preliminary X-ray diffraction analysis of the Interleukin-3 alpha receptor bound to Fab fragment of antibody
Acta Crystallogr F Struct Biol Commun.
Hardy, MP Lopez, AF Owczarek, CM Wilson, NJ Dhagat, U Nash, AD Nero, TL Scotney, PD Hercus, TR Fabri, LJ Broughton, SE Parker, MW
2014 Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362
Acta Crystallographica Section F-structural Biology And Crystallization Communications
Broughton, SE Hercus, TR Nero, TL Dhagat, U Owczarek, CM Hardy, MP Fabri, LJ Scotney, PD Nash, AD Wilson, NJ Lopez, AF Parker, MW
2014 Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of anti
Acta Crystallographica Section F-structural Biology Communications
Broughton, SE Hercus, TR Nero, TL Dhagat, U Owczarek, CM Hardy, MP Fabri, LJ Scotney, PD Nash, AD Wilson, NJ Lopez, AF Parker, MW
2014 A Systematic and Functional Classification of Streptococcus pyogenes That Serves as a New Tool for Molecular Typing and Vaccine Development
Journal Of Infectious Diseases
Sanderson-Smith, M De Oliveira, DMP Guglielmini, J McMillan, DJ Vu, T Holien, JK Henningham, A Steer, AC Bessen, DE Dale, JB Curtis, N Beall, BW Walker, MJ Parker, MW Carapetis, JR Van Melderen, L Sriprakash, KS Smeesters, PR
2015 Computational analysis of amiloride analogue inhibitors of coxsackievirus B3 RNA polymerase
J Proteomics Bioinform
Jarrott, B Elliott, RW Gazina, EV Parker, MW Holien, JK Williams, SJ Cameron, CE Petrou, S
2015 Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form
Structure
Parker, MW Linkugel, AD Goel, HL Wu, T Mercurio, AM Vander Kooi, CW
2015 Extracorporeal Membrane Oxygenation as a Bridge to Surgery for Infective Endocarditis Complicated by Aorto-Atrial Fistula and Ca
Texas Heart Institute Journal
Noyes, AM Ramu, B Parker, MW Underhill, D
2015 Molecular basis for mid-region amyloid-beta capture by leading Alzheimer's disease immunotherapies
Scientific Reports
Crespi, GAN Hermans, SJ Parker, MW Miles, LA
2015 Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding
Biochemical Journal
Tomlinson, CG Moye, AL Holien, JK Parker, MW Cohen, SB Bryan, TM
2015 Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9
Bioorganic & Medicinal Chemistry
Phillipson, LJ Segal, DH Nero, TL Parker, MW Wan, SS de Silva, M Guthridge, MA Wei, AH Burns, CJ
2015 Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-truncated Abeta in sporadic Alzheimer disease cases and mouse models
Acta Neuropathol.
Bouter, Y Noguerola, JSL Tucholla, P Crespi, GAN Parker, MW Wiltfang, J Miles, LA Bayer, TA
2015 An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin
Proceedings Of The National Academy Of Sciences Of The United States Of America
Wade, KR Hotze, EM Kuiper, MJ Morton, CJ Parker, MW Tweten, RK
2015 Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-trunc
Acta Neuropathologica
Bouter Y Noguerola JSL Tucholla P Crespi GAN Parker, MW Wiltfang J Miles, LA Bayer TA
2015 Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and efficiency
J. Steroid Biochem. Mol. Biol.
Martin, LL Holien, JK Mizrachi, D Corbin, CJ Conley, AJ Parker, MW Rodgers, RJ
2015 Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and effic
Journal Of Steroid Biochemistry And Molecular Biology
Martin, LL Holien, JK Mizrachi, D Corbin, CJ Conley, AJ Parker, MW Rodgers, RJ
2015 Crystal structure of the lysine specific protease Kgp, isolated from Porphyromonas gingivalis, a target for improved oral health
Protein Sci
Seers, CA Reynolds, EC Gorman, MA Cross, KJ Huq, NL Feil, SC Michell, BJ Parker, MW
2015 The beta c receptor family - Structural insights and their functional implications
Cytokine
Broughton, SE Nero, TL Dhagat, U Kan, WL Hercus, TR Tvorogov, D Lopez, AF Parker, MW
2015 Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase
Biochem. J.
Mobbs, JI Koay, A Di Paolo, A Bieri, M Petrie, EJ Gorman, MA Doughty, L Parker, MW Stapleton, DI Griffin, MDW Gooley, PR
2015 Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health
Protein Science
Gorman, MA Seers, CA Michell, BJ Feil, SC Huq, NL Cross, KJ Reynolds, EC Parker, MW
2015 Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase
Biochemical Journal
Mobbs, JI Koay, A Di Paolo, A Bieri, M Petrie, EJ Gorman, MA Doughty, L Parker, MW Stapleton, DI Griffin, MD Gooley, PR
2015 Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides
Protein Science
Hermans, SJ Ascher, DB Hancock, NC Holien, JK Michell, BJ Chai, SY Morton, CJ Parker, MW
2015 Propargyloxyproline Regio- and Stereoisomers for Click-Conjugation of Peptides: Synthesis and Application in Linear and Cyclic P
Australian Journal Of Chemistry
Northfield, SE Mountford, SJ Wielens, J Liu, M Zhang, L Herzog, H Holliday, ND Scanlon, MJ Parker, MW Chalmers, DK Thompson, PE
2015 Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation
Scientific Reports
Lawrence, S Feil, SC Morton, CJ Farrand, AJ Mulhern, TD Gorman, MA Wade, KR Tweten, RK Parker, MW
2015 Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation
Sci Rep
Lawrence, SL Feil, SC Morton, CJ Farrand, AJ Mulhern, TD Gorman, MA Wade, KR Tweten, RK Parker, MW
2015 Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1)
Plos One
Simonov, AN Holien, JK Yeung, JCI Nguyen, AD Corbin, CJ Zheng, J Kuznetsov, VL Auchus, RJ Conley, AJ Bond, AM Parker, MW Rodgers, RJ Martin, LL
2015 Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1)
Plos One
Simonov, AN Holien, JK Yeung, JC Nguyen, AD Corbin, CJ Zheng, J Kuznetsov, VL Auchus, RJ Conley, AJ Bond, AM Parker, MW Rodgers, RJ Martin, LL
2015 Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators
Journal Of Experimental Medicine
Flierl, U Nero, TL Lim, B Arthur, JF Yao, Y Jung, SM Gitz, E Pollitt, AY Zaldivia, MTK Jandrot-Perrus, M Schafer, A Nieswandt, B Andrews, RK Parker, MW Gardiner, EE Peter, K
2015 A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production
Nature Communications
Nachbur, U Stafford, CA Bankovacki, A Zhan, YF Lindqvist, LM Fiil, BK Khakham, Y Ko, HJ Sandow, JJ Falk, H Holien, JK Chau, D Hildebrand, J Vince, JE Sharp, PP Webb, AI Jackman, KA Muhlen, S Kennedy, CL Lowes, KN Murphy, JM Gyrd-Hansen, M Parker, MW Hartland, EL Lew, AM Huang, DCS Lessene, G Silke, J
2016 The C-terminal extension of human telomerase reverse transcriptase is necessary for high affinity binding to telomeric DNA
Biochimie
Tomlinson, CG Holien, JK Mathias, JAT Parker, MW Bryan, TM
2016 Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding
Nat. Commun.
Langendorf, CG Ngoei, KRW Scott, JW Ling, NXY Issa, SMA Gorman, MA Parker, MW Sakamoto, K Oakhill, JS Kemp, BE
2016 Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins
Structure
Lawrence, SL Gorman, MA Feil, SC Mulhern, TD Kuiper, MJ Ratner, AJ Tweten, RK Morton, CJ Parker, MW
2016 The Binding of Syndapin SH3 Domain to Dynamin Proline-rich Domain Involves Short and Long Distance Elements
J. Biol. Chem.
Luo, L Xue, J Kwan, A Gamsjaeger, R Wielens, J von Kleist, L Cubeddu, L Guo, Z Stow, JL Parker, MW Mackay, JP Robinson, PJ
2016 Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling
Structure
Broughton, SE Hercus, TR Nero, TL Dottore, M McClure, BJ Dhagat, U Taing, H Gorman, MA King-Scott, J Lopez, AF Parker, MW
2016 Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target
Structure
da Costa, TPS Desbois, S Dogovski, C Gorman, MA Ketaren, NE Paxman, JJ Siddiqui, T Zammit, LM Abbott, BM Robins-Browne, RM Parker, MW Jameson, GB Hall, NE Panjikar, S Perugini, MA
2016 CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common beta chain of the IL-3, GM-CSF and IL-5 receptors
Mabs
Panousis, C Dhagat, U Edwards, KM Rayzman, V Hardy, MP Braley, H Gauvreau, GM Hercus, TR Smith, S Sehmi, R McMillan, L Dottore, M McClure, BJ Fabri, LJ Vairo, G Lopez, AF Parker, MW Nash, AD Wilson, NJ Wilson, MJ Owczarek, CM
2017 Homodimer Model Can Resolve the Conundrum as to How Cytochrome P450 Oxidoreductase and Cytochrome b5 Compete for the Same Binding Site on Cytochrome P450c17
Curr. Protein Pept. Sci.
Holien, JK Parker, MW Conley, AJ Corbin, CJ Rodgers, RJ Martin, LL
2017 QM/MM simulations provide insight into the mechanism of bioluminescence triggering in ctenophore photoproteins
Plos One
Molakarimi, M Mohseni, A Taghdir, M Pashandi, Z Gorman, MA Parker, MW Naderi-Manesh, H Sajedi, RH
2017 Control of Virulence Gene Expression by the Master Regulator, CfaD, in the Prototypical Enterotoxigenic Escherichia coli Strain, H10407
Front. Microbiol.
Hodson, C Yang, J Hocking, DM Azzopardi, K Chen, QY Holien, JK Parker, MW Tauschek, M Robins-Browne, RM
2017 Ex vivo O-18-labeling mass spectrometry identifies a peripheral amyloid beta clearance pathway
Mol. Neurodegener.
Portelius, E Mattsson, N Pannee, J Zetterberg, H Gisslen, M Vanderstichele, H Gkanatsiou, E Crespi, GAN Parker, MW Miles, LA Gobom, J Blennow, K
2017 Glutathione transferase P1-1 as an arsenic drug-sequestering enzyme
Protein Sci.
Parker, LJ Bocedi, A Ascher, DB Aitken, JB Harris, HH Lo Bello, M Ricci, G Morton, CJ Parker, MW
2017 Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability
Nucleic Acids Res.
Gillinder, KR Ilsley, MD Nebor, D Sachidanandam, R Lajoie, M Magor, GW Tallack, MR Bailey, T Landsberg, MJ Mackay, JP Parker, MW Miles, LA Graber, JH Peters, LL Bieker, JJ Perkins, AC
2017 Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites
Nat. Commun.
Braig, D Nero, TL Koch, HG Kaiser, B Wang, XW Thiele, JR Morton, CJ Zeller, J Kiefer, J Potempa, LA Mellett, NA Miles, LA Du, XJ Meikle, PJ Huber-Lang, M Stark, GB Parker, MW Peter, K Eisenhardt, SU
2018 Protein structure and computational drug discovery
Biochem. Soc. Trans.
Nero, TL Parker, MW Morton, CJ
2018 Nitric Oxide Interacting with Glutathione Transferases
Lo Bello, M Parker, LJ Parker, MW Ricci, G
2018 AMP and adenosine are both ligands for adenosine 2B receptor signaling
Bioorg. Med. Chem. Lett.
Holien, JK Seibt, B Roberts, V Salvaris, E Parker, MW Cowan, PJ Dwyer, KM
2018 Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: comment
J. Thromb. Haemost.
Flierl, U Nero, TL Lim, B Andrews, RK Parker, MW Gardiner, EE Peter, K
2018 Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase
Chemmedchem
Northfield, SE Wielens, J Headey, SJ Williams-Noonan, BJ Mulcair, M Scanlon, MJ Parker, MW Thompson, PE Chalmers, DK
2018 Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis
Elife
Marquez, CL Lau, D Walsh, J Shah, V McGuinness, C Wong, A Aggarwal, A Parker, MW Jacques, DA Turville, S Bocking, T
2018 EPO does not promote interaction between the erythropoietin and beta-common receptors
Sci Rep
Shing, KSCT Broughton, SE Nero, TL Gillinder, K Ilsley, MD Ramshaw, H Lopez, AF Griffin, MDW Parker, MW Perkins, AC Dhagat, U
2018 Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target
Structure
Atkinson, SC Dogovski, C Wood, K Griffin, MDW Gorman, MA Hor, L Reboul, CF Buckle, AM Wuttke, J Parker, MW Dobson, RC Perugini, MA
2018 Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis
Sci. Adv.
Tvorogov, D Thomas, D Liau, NPD Dottore, M Barry, EF Lathi, M Kan, WL Hercus, TR Stomski, F Hughes, TP Tergaonkar, V Parker, MW Ross, DM Majeti, R Babon, JJ Lopez, AF
2018 The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities
Mabs
Dhagat, U Hercus, TR Broughton, SE Nero, TL Shing, KSCT Barry, EF Thomson, CA Bryson, S Pai, EF McClure, BJ Schrader, JW Lopez, AF Parker, MW
2018 Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4
Cell Chem. Biol.
Ngoei, KRW Langendorf, CG Ling, NXY Hoque, A Varghese, S Camerino, MA Walker, SR Bozikis, YE Dite, TA Ovens, AJ Smiles, WJ Jacobs, R Huang, H Parker, MW Scott, JW Rider, MH Foitzik, RC Kemp, BE Baell, JB Oakhill, JS
2018 A dual role for the N-terminal domain of the IL-3 receptor in cell signalling
Nat. Commun.
Broughton, SE Hercus, TR Nero, TL Kan, WL Barry, EF Dottore, M Shing, KSCT Morton, CJ Dhagat, U Hardy, MP Wilson, NJ Downton, MT Schieber, C Hughes, TP Lopez, AF Parker, MW
2018 Role of the beta Common (beta c) Family of Cytokines in Health and Disease
Cold Spring Harbor Perspect. Biol.
Hercus, TR Kan, WLT Broughton, SE Tvorogov, D Ramshaw, HS Sandow, JJ Nero, TL Dhagat, U Thompson, EJ Shing, KSCT McKenzie, DR Wilson, NJ Owczarek, CM Vairo, G Nash, AD Tergaonkar, V Hughes, T Ekert, PG Samuel, MS Bonder, CS Grimbaldeston, MA Parker, MW Lopez, AF
2018 Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth
Nature
Baell, JB Leaver, DJ Hermans, SJ Kelly, GL Brennan, MS Downer, NL Nguyen, N Wichmann, J Mcrae, HM Yang, YQ Cleary, B Lagiakos, HR Mieruszynski, S Pacini, G Vanyai, HK Bergamasco, MI May, RE Davey, BK Morgan, KJ Sealey, AJ Wang, BN Zamudio, N Wilcox, S Garnham, AL Sheikh, BN Aubrey, BJ Doggett, K Chung, MC de Silva, M Bentley, J Pilling, P Hattarki, M Dolezal, O Dennis, ML Falk, H Ren, B Charman, SA White, KL Rautela, J Newbold, A Hawkins, ED Johnstone, RW Huntington, ND Peat, TS Heath, JK Strasser, A Parker, MW Smyth, GK Street, IP Monahan, BJ Voss, AK Thomas, T
2019 Reaction mechanism of the bioluminescent protein mnemiopsin1 revealed by X-ray crystallography and QM/MM simulations
J. Biol. Chem.
Molakarimi, M Gorman, MA Mohseni, A Pashandi, Z Taghdir, M Naderi-Manesh, H Sajedi, RH Parker, MW