Publications by Researcher: Parker, MW

YearTitleAuthor(s)
2012 Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2
Ascher, DB Polekhina, G Parker, MW
2012 Cytokine receptor activation at the cell surface
Broughton, SE Hercus, TR Lopez, AF Parker, MW
2012 Intracellular beta-Nicotinamide Adenine Dinucleotide Inhibits the Skeletal Muscle ClC-1 Chloride Channel
Bennetts, B Yu, YW Chen, TY Parker, MW
2012 PEGylation of a proprotein convertase peptide inhibitor for vaginal route of drug delivery: In vitro bioactivity, stability and in vivo pharmacokinetics
Ho, HT Nero, TL Singh, H Parker, MW Nie, GY
2012 Monomer-Monomer Interactions Propagate Structural Transitions Necessary for Pore Formation by the Cholesterol-dependent Cytolysins
Hotze, EM Wilson-Kubalek, E Farrand, AJ Bentsen, L Parker, MW Johnson, AE Tweten, RK
2012 TRIM16 Acts as an E3 Ubiquitin Ligase and Can Heterodimerize with Other TRIM Family Members
Bell, JL Malyukova, A Holien, JK Koach, J Parker, MW Kavallaris, M Marshall, GM Cheung, BB
2012 Structural approaches to probing metal interaction with proteins
Parker, LJ Ascher, DB Gao, C Miles, LA Harris, HH Parker, MW
2012 Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation
Quana, A Xue, J Wielens, J Smillie, KJ Anggono, V Parker, MW Cousin, MA Graham, ME Robinson, PJ
2012 An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus
Feil, SC Hamilton, S Krippner, GY Lin, B Luttick, A McConnell, DB Nearn, R Parker, MW Ryan, J Stanislawski, PC Tucker, SP Watson, KG Morton, CJ
2012 The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling
Broughton, SE Dhagat, U Hercus, TR Nero, TL Grimbaldeston, MA Bonder, CS Lopez, AF Parker, MW
2012 Structure of the Lectin Regulatory Domain of the Cholesterol-Dependent Cytolysin Lectinolysin Reveals the Basis for Its Lewis Antigen Specificity
Feil, SC Lawrence, S Mulhern, TD Holien, JK Hotze, EM Farrand, S Tweten, RK Parker, MW
2012 The GM-CSF receptor family: Mechanism of activation and implications for disease
Hercus, TR Broughton, SE Ekert, PG Ramshaw, HS Perugini, M Grimbaldeston, M Woodcock, JM Thomas, D Pitson, S Hughes, T D’Andrea, RJ Parker, MW Lopez, AF
2013 Molecular determinants of common gating of a ClC chloride channel
Bennetts, B Parker, MW
2013 Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34
Suryadinata, R Holien, JK Yang, G Parker, MW Papaleo, E Sarcevic, B
2013 Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation
Miles, LA Crespi, GAN Doughty, L Parker, MW
2013 Small Molecule Proprotein Convertase Inhibitors for Inhibition of Embryo Implantation
Ho, HT Singh, H Heng, S Nero, TL Paule, S Parker, MW Johnson, AT Jiao, GS Nie, GY
2013 Lymphotoxin alpha induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor
Etemadi, N Holien, JK Chau, D Dewson, G Murphy, JM Alexander, WS Parker, MW Silke, J Nachbur, U
2013 Disarming Bacterial Virulence through Chemical Inhibition of the DNA Binding Domain of an AraC-like Transcriptional Activator Protein
Yang, J Hocking, DM Cheng, C Dogovski, C Perugini, MA Holien, JK Parker, MW Hartland, EL Tauschek, M Robins-Browne, RM
2013 Phosphorylation of Serine 779 in Fibroblast Growth Factor Receptor 1 and 2 by Protein Kinase C epsilon Regulates Ras/Mitogen-activated Protein Kinase Signaling and Neuronal Differentiation
Lonic, A Powell, JA Kong, Y Thomas, D Holien, JK Truong, N Parker, MW Guthridge, MA
2013 Synthetic dityrosine-linked beta-amyloid dimers form stable, soluble, neurotoxic oligomers
Kok, WM Cottam, JM Ciccotosto, GD Miles, LA Karas, JA Scanlon, DB Roberts, BR Parker, MW Cappai, R Barnham, KJ Hutton, CA
2013 Characterization of pathogenic human monoclonal autoantibodies against GM-CSF
Wang, YN Thomson, CA Allan, LL Jackson, LM Olson, M Hercus, TR Nero, TL Turner, A Parker, MW Lopez, AL Waddell, TK Anderson, GP Hamilton, JA Schrader, JW
2013 Parallel Screening of Low Molecular Weight Fragment Libraries: Do Differences in Methodology Affect Hit Identification?
Wielens, J Headey, SJ Rhodes, DI Mulder, RJ Dolezal, O Deadman, JJ Newman, J Chalmers, DK Parker, MW Peat, TS Scanlon, MJ
2013 Signalling by the beta c family of cytokines
Hercus, TR Dhagat, U Kan, WLT Broughton, SE Nero, TL Perugini, M Sandow, JJ D’Andrea, RJ Ekert, PG Hughes, T Parker, MW Lopez, AF
2013 From Knock-Out Phenotype to Three-Dimensional Structure of a Promising Antibiotic Target from Streptococcus pneumoniae
Dogovski, C Gorman, MA Ketaren, NE Praszkier, J Zammit, LM Mertens, HD Bryant, G Yang, J Griffin, MDW Pearce, FG Gerrard, JA Jameson, GB Parker, MW Robins-Browne, RM Perugini, MA
2013 Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription
Thomas, D Powell, JA Vergez, F Segal, DH Nguyen, NYN Baker, A Teh, TC Barry, EF Sarry, JE Lee, EM Nero, TL Jabbour, AM Pomilio, G Green, BD Manenti, S Glaser, SP Parker, MW Lopez, AF Ekert, PG Lock, RB Huang, DCS Nilsson, SK Recher, C Wei, AH Guthridge, MA
2013 The Impact of Nitric Oxide Toxicity on the Evolution of the Glutathione Transferase Superfamily A PROPOSAL FOR AN EVOLUTIONARY DRIVING FORCE
Bocedi, A Fabrini, R Farrotti, A Stella, L Ketterman, AJ Pedersen, JZ Allocati, N Lau, PCK Grosse, S Eltis, LD Ruzzini, A Edwards, TE Morici, L Del Grosso, E Guidoni, L Bovi, D Lo Bello, M Federici, G Parker, MW Board, PG Ricci, G
2014 Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody.
Huynh, H Scotney, PD Dottore, M Dhagat, U Nash, AD McClure, BJ Kan, WL Owczarek, CM Broughton, SE Barry, EF Busfield, SJ Wilson, NJ Hardy, MP Braley, H Hartman, D Parker, MW Hercus, TR Lopez, AF
2014 Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-beta
Crespi, GAN Ascher, DB Parker, MW Miles, LA
2014 Tetraspanins as regulators of the tumour microenvironment: implications for metastasis and therapeutic strategies
Detchokul, S Williams, ED Parker, MW Frauman, AG
2014 Activity-Modulating Monoclonal Antibodies to the Human Serine Protease HtrA3 Provide Novel Insights into Regulating HtrA Proteol
Singh, H Nero, TL Wang, Y Parker, MW Nie, GY
2014 Structural Studies of Streptococcus pyogenes Streptolysin O Provide Insights into the Early Steps of Membrane Penetration
Feil, SC Ascher, DB Kuiper, MJ Tweten, RK Parker, MW
2014 Oncogenic protein interfaces: small molecules, big challenges
Nero, TL Morton, CJ Holien, JK Wielens, J Parker, MW
2014 Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
Ascher, DB Wielens, J Nero, TL Doughty, L Morton, CJ Parker, MW
2014 Synthesis, Structure-Activity Relationships and Brain Uptake of a Novel Series of Benzopyran Inhibitors of Insulin-Regulated Aminopeptidase
Mountford, SJ Albiston, AL Charman, WN Ng, L Holien, JK Parker, MW Nicolazzo, JA Thompson, PE Chai, SY
2014 The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster
Remnant, EJ Morton, CJ Daborn, PJ Lumb, C Yang, YT Ng, HL Parker, MW Batterham, P
2014 Do current therapeutic anti-A beta antibodies for Alzheimer's disease engage the target?
Watt, AD Crespi, GAN Down, RA Ascher, DB Gunn, A Perez, KA McLean, CA Villemagne, VL Parker, MW Barnham, KJ Miles, LA
2014 Anti-A beta antibody target engagement: a response to Siemers et al.
Watt, AD Crespi, GAN Down, RA Ascher, DB Gunn, A Perez, KA McLean, CA Villemagne, VL Parker, MW Barnham, KJ Miles, LA
2014 Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor
Brooks, AJ Dai, W O’Mara, ML Abankwa, D Chhabra, Y Pelekanos, RA Gardon, O Tunny, KA Blucher, KM Morton, CJ Parker, MW Sierecki, E Gambin, Y Gomez, GA Alexandrov, K Wilson, IA Doxastakis, M Mark, AE Waters, MJ
2014 Crystallisation and preliminary X-ray diffraction analysis of the Interleukin-3 alpha receptor bound to Fab fragment of antibody
Dhagat, U Nash, AD Nero, TL Scotney, PD Hercus, TR Fabri, LJ Broughton, SE Hardy, MP Lopez, AF Owczarek, CM Wilson, NJ Parker, MW
2014 Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362
Broughton, SE Hercus, TR Nero, TL Dhagat, U Owczarek, CM Hardy, MP Fabri, LJ Scotney, PD Nash, AD Wilson, NJ Lopez, AF Parker, MW
2014 Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of anti
Broughton, SE Hercus, TR Nero, TL Dhagat, U Owczarek, CM Hardy, MP Fabri, LJ Scotney, PD Nash, AD Wilson, NJ Lopez, AF Parker, MW
2014 A Systematic and Functional Classification of Streptococcus pyogenes That Serves as a New Tool for Molecular Typing and Vaccine Development
Sanderson-Smith, M De Oliveira, DMP Guglielmini, J McMillan, DJ Vu, T Holien, JK Henningham, A Steer, AC Bessen, DE Dale, JB Curtis, N Beall, BW Walker, MJ Parker, MW Carapetis, JR Van Melderen, L Sriprakash, KS Smeesters, PR
2015 Computational analysis of amiloride analogue inhibitors of coxsackievirus B3 RNA polymerase
Gazina, EV Parker, MW Holien, JK Williams, SJ Cameron, CE Jarrott, B Elliott, RW Petrou, S
2015 Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form
Parker, MW Linkugel, AD Goel, HL Wu, T Mercurio, AM Vander Kooi, CW
2015 Molecular basis for mid-region amyloid-beta capture by leading Alzheimer's disease immunotherapies
Crespi, GAN Hermans, SJ Parker, MW Miles, LA
2015 Extracorporeal Membrane Oxygenation as a Bridge to Surgery for Infective Endocarditis Complicated by Aorto-Atrial Fistula and Ca
Noyes, AM Ramu, B Parker, MW Underhill, D
2015 Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9
Phillipson, LJ Segal, DH Nero, TL Parker, MW Wan, SS de Silva, M Guthridge, MA Wei, AH Burns, CJ
2015 Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding
Tomlinson, CG Moye, AL Holien, JK Parker, MW Cohen, SB Bryan, TM
2015 An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin
Wade, KR Hotze, EM Kuiper, MJ Morton, CJ Parker, MW Tweten, RK
2015 Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-trunc
Bouter Y Noguerola JSL Tucholla P Crespi GAN Parker, MW Wiltfang J Miles, LA Bayer TA
2015 Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-truncated Abeta in sporadic Alzheimer disease cases and mouse models
Bouter, Y Noguerola, JSL Tucholla, P Crespi, GAN Parker, MW Wiltfang, J Miles, LA Bayer, TA
2015 Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and efficiency
Martin, LL Holien, JK Mizrachi, D Corbin, CJ Conley, AJ Parker, MW Rodgers, RJ
2015 Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and effic
Martin, LL Holien, JK Mizrachi, D Corbin, CJ Conley, AJ Parker, MW Rodgers, RJ
2015 Crystal structure of the lysine specific protease Kgp, isolated from Porphyromonas gingivalis, a target for improved oral health
Huq, NL Feil, SC Michell, BJ Seers, CA Reynolds, EC Gorman, MA Cross, KJ Parker, MW
2015 Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase
Mobbs, JI Koay, A Di Paolo, A Bieri, M Petrie, EJ Gorman, MA Doughty, L Parker, MW Stapleton, DI Griffin, MDW Gooley, PR
2015 Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health
Gorman, MA Seers, CA Michell, BJ Feil, SC Huq, NL Cross, KJ Reynolds, EC Parker, MW
2015 Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase
Mobbs, JI Koay, A Di Paolo, A Bieri, M Petrie, EJ Gorman, MA Doughty, L Parker, MW Stapleton, DI Griffin, MD Gooley, PR
2015 Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides
Hermans, SJ Ascher, DB Hancock, NC Holien, JK Michell, BJ Chai, SY Morton, CJ Parker, MW
2015 The beta c receptor family - Structural insights and their functional implications
Broughton, SE Nero, TL Dhagat, U Kan, WL Hercus, TR Tvorogov, D Lopez, AF Parker, MW
2015 Propargyloxyproline Regio- and Stereoisomers for Click-Conjugation of Peptides: Synthesis and Application in Linear and Cyclic P
Northfield, SE Mountford, SJ Wielens, J Liu, M Zhang, L Herzog, H Holliday, ND Scanlon, MJ Parker, MW Chalmers, DK Thompson, PE
2015 Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation
Lawrence, S Feil, SC Morton, CJ Farrand, AJ Mulhern, TD Gorman, MA Wade, KR Tweten, RK Parker, MW
2015 Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation
Lawrence, SL Feil, SC Morton, CJ Farrand, AJ Mulhern, TD Gorman, MA Wade, KR Tweten, RK Parker, MW
2015 Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1)
Simonov, AN Holien, JK Yeung, JCI Nguyen, AD Corbin, CJ Zheng, J Kuznetsov, VL Auchus, RJ Conley, AJ Bond, AM Parker, MW Rodgers, RJ Martin, LL
2015 Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1)
Simonov, AN Holien, JK Yeung, JC Nguyen, AD Corbin, CJ Zheng, J Kuznetsov, VL Auchus, RJ Conley, AJ Bond, AM Parker, MW Rodgers, RJ Martin, LL
2015 Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators
Flierl, U Nero, TL Lim, B Arthur, JF Yao, Y Jung, SM Gitz, E Pollitt, AY Zaldivia, MTK Jandrot-Perrus, M Schafer, A Nieswandt, B Andrews, RK Parker, MW Gardiner, EE Peter, K
2015 A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production
Nachbur, U Stafford, CA Bankovacki, A Zhan, YF Lindqvist, LM Fiil, BK Khakham, Y Ko, HJ Sandow, JJ Falk, H Holien, JK Chau, D Hildebrand, J Vince, JE Sharp, PP Webb, AI Jackman, KA Muhlen, S Kennedy, CL Lowes, KN Murphy, JM Gyrd-Hansen, M Parker, MW Hartland, EL Lew, AM Huang, DCS Lessene, G Silke, J
2016 Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding
Langendorf, CG Ngoei, KRW Scott, JW Ling, NXY Issa, SMA Gorman, MA Parker, MW Sakamoto, K Oakhill, JS Kemp, BE