Publications by Researcher: Parker, MW

Year	Title	Author(s)
2012	Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2 Acta Crystallographica Section F-structural Biology And Crystallization Communications	Ascher, DB Polekhina, G Parker, MW
2012	Intracellular beta-Nicotinamide Adenine Dinucleotide Inhibits the Skeletal Muscle ClC-1 Chloride Channel Journal Of Biological Chemistry	Bennetts, B Yu, YW Chen, TY Parker, MW
2012	PEGylation of a proprotein convertase peptide inhibitor for vaginal route of drug delivery: In vitro bioactivity, stability and in vivo pharmacokinetics Peptides	Ho, HT Nero, TL Singh, H Parker, MW Nie, GY
2012	Cytokine receptor activation at the cell surface Current Opinion In Structural Biology	Broughton, SE Hercus, TR Lopez, AF Parker, MW
2012	Monomer-Monomer Interactions Propagate Structural Transitions Necessary for Pore Formation by the Cholesterol-dependent Cytolysins Journal Of Biological Chemistry	Hotze, EM Wilson-Kubalek, E Farrand, AJ Bentsen, L Parker, MW Johnson, AE Tweten, RK
2012	TRIM16 Acts as an E3 Ubiquitin Ligase and Can Heterodimerize with Other TRIM Family Members Plos One	Bell, JL Malyukova, A Holien, JK Koach, J Parker, MW Kavallaris, M Marshall, GM Cheung, BB
2012	Structural approaches to probing metal interaction with proteins Journal Of Inorganic Biochemistry	Parker, LJ Ascher, DB Gao, C Miles, LA Harris, HH Parker, MW
2012	Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation Proceedings Of The National Academy Of Sciences Of The United States Of America	Quana, A Xue, J Wielens, J Smillie, KJ Anggono, V Parker, MW Cousin, MA Graham, ME Robinson, PJ
2012	An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus Acs Medicinal Chemistry Letters	Feil, SC Hamilton, S Krippner, GY Lin, B Luttick, A McConnell, DB Nearn, R Parker, MW Ryan, J Stanislawski, PC Tucker, SP Watson, KG Morton, CJ
2012	The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling Immunological Reviews	Broughton, SE Dhagat, U Hercus, TR Nero, TL Grimbaldeston, MA Bonder, CS Lopez, AF Parker, MW
2012	Structure of the Lectin Regulatory Domain of the Cholesterol-Dependent Cytolysin Lectinolysin Reveals the Basis for Its Lewis Antigen Specificity Structure	Feil, SC Lawrence, S Mulhern, TD Holien, JK Hotze, EM Farrand, S Tweten, RK Parker, MW
2012	The GM-CSF receptor family: Mechanism of activation and implications for disease Growth Factors	Hercus, TR Broughton, SE Ekert, PG Ramshaw, HS Perugini, M Grimbaldeston, M Woodcock, JM Thomas, D Pitson, S Hughes, T D’Andrea, RJ Parker, MW Lopez, AF
2013	Molecular determinants of common gating of a ClC chloride channel Nature Communications	Bennetts, B Parker, MW
2013	Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34 Cell Cycle	Suryadinata, R Holien, JK Yang, G Parker, MW Papaleo, E Sarcevic, B
2013	Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation Scientific Reports	Miles, LA Crespi, GAN Doughty, L Parker, MW
2013	Small Molecule Proprotein Convertase Inhibitors for Inhibition of Embryo Implantation Plos One	Ho, HT Singh, H Heng, S Nero, TL Paule, S Parker, MW Johnson, AT Jiao, GS Nie, GY
2013	Lymphotoxin alpha induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor Febs Journal	Etemadi, N Holien, JK Chau, D Dewson, G Murphy, JM Alexander, WS Parker, MW Silke, J Nachbur, U
2013	Phosphorylation of Serine 779 in Fibroblast Growth Factor Receptor 1 and 2 by Protein Kinase C epsilon Regulates Ras/Mitogen-activated Protein Kinase Signaling and Neuronal Differentiation Journal Of Biological Chemistry	Lonic, A Powell, JA Kong, Y Thomas, D Holien, JK Truong, N Parker, MW Guthridge, MA
2013	Disarming Bacterial Virulence through Chemical Inhibition of the DNA Binding Domain of an AraC-like Transcriptional Activator Protein Journal Of Biological Chemistry	Yang, J Hocking, DM Cheng, C Dogovski, C Perugini, MA Holien, JK Parker, MW Hartland, EL Tauschek, M Robins-Browne, RM
2013	Synthetic dityrosine-linked beta-amyloid dimers form stable, soluble, neurotoxic oligomers Chemical Science	Kok, WM Cottam, JM Ciccotosto, GD Miles, LA Karas, JA Scanlon, DB Roberts, BR Parker, MW Cappai, R Barnham, KJ Hutton, CA
2013	Characterization of pathogenic human monoclonal autoantibodies against GM-CSF Proceedings Of The National Academy Of Sciences Of The United States Of America	Wang, YN Thomson, CA Allan, LL Jackson, LM Olson, M Hercus, TR Nero, TL Turner, A Parker, MW Lopez, AL Waddell, TK Anderson, GP Hamilton, JA Schrader, JW
2013	Parallel Screening of Low Molecular Weight Fragment Libraries: Do Differences in Methodology Affect Hit Identification? Journal Of Biomolecular Screening	Wielens, J Headey, SJ Rhodes, DI Mulder, RJ Dolezal, O Deadman, JJ Newman, J Chalmers, DK Parker, MW Peat, TS Scanlon, MJ
2013	Signalling by the beta c family of cytokines Cytokine & Growth Factor Reviews	Hercus, TR Dhagat, U Kan, WLT Broughton, SE Nero, TL Perugini, M Sandow, JJ D’Andrea, RJ Ekert, PG Hughes, T Parker, MW Lopez, AF
2013	From Knock-Out Phenotype to Three-Dimensional Structure of a Promising Antibiotic Target from Streptococcus pneumoniae Plos One	Dogovski, C Gorman, MA Ketaren, NE Praszkier, J Zammit, LM Mertens, HD Bryant, G Yang, J Griffin, MDW Pearce, FG Gerrard, JA Jameson, GB Parker, MW Robins-Browne, RM Perugini, MA
2013	Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription Blood	Thomas, D Powell, JA Vergez, F Segal, DH Nguyen, NYN Baker, A Teh, TC Barry, EF Sarry, JE Lee, EM Nero, TL Jabbour, AM Pomilio, G Green, BD Manenti, S Glaser, SP Parker, MW Lopez, AF Ekert, PG Lock, RB Huang, DCS Nilsson, SK Recher, C Wei, AH Guthridge, MA
2013	The Impact of Nitric Oxide Toxicity on the Evolution of the Glutathione Transferase Superfamily A PROPOSAL FOR AN EVOLUTIONARY DRIVING FORCE Journal Of Biological Chemistry	Bocedi, A Fabrini, R Farrotti, A Stella, L Ketterman, AJ Pedersen, JZ Allocati, N Lau, PCK Grosse, S Eltis, LD Ruzzini, A Edwards, TE Morici, L Del Grosso, E Guidoni, L Bovi, D Lo Bello, M Federici, G Parker, MW Board, PG Ricci, G
2014	Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody. Cell Rep	Wilson, NJ Dottore, M Dhagat, U Nash, AD McClure, BJ Kan, WL Owczarek, CM Broughton, SE Barry, EF Busfield, SJ Hardy, MP Braley, H Hartman, D Parker, MW Hercus, TR Huynh, H Scotney, PD Lopez, AF
2014	Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-beta Acta Crystallographica Section F-structural Biology And Crystallization Communications	Crespi, GAN Ascher, DB Parker, MW Miles, LA
2014	Tetraspanins as regulators of the tumour microenvironment: implications for metastasis and therapeutic strategies British Journal Of Pharmacology	Detchokul, S Williams, ED Parker, MW Frauman, AG
2014	Activity-Modulating Monoclonal Antibodies to the Human Serine Protease HtrA3 Provide Novel Insights into Regulating HtrA Proteol Plos One	Singh, H Nero, TL Wang, Y Parker, MW Nie, GY
2014	Oncogenic protein interfaces: small molecules, big challenges Nature Reviews Cancer	Nero, TL Morton, CJ Holien, JK Wielens, J Parker, MW
2014	Structural Studies of Streptococcus pyogenes Streptolysin O Provide Insights into the Early Steps of Membrane Penetration Journal Of Molecular Biology	Feil, SC Ascher, DB Kuiper, MJ Tweten, RK Parker, MW
2014	Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA Scientific Reports	Ascher, DB Wielens, J Nero, TL Doughty, L Morton, CJ Parker, MW
2014	Synthesis, Structure-Activity Relationships and Brain Uptake of a Novel Series of Benzopyran Inhibitors of Insulin-Regulated Aminopeptidase Journal Of Medicinal Chemistry	Mountford, SJ Albiston, AL Charman, WN Ng, L Holien, JK Parker, MW Nicolazzo, JA Thompson, PE Chai, SY
2014	The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster Insect Biochemistry And Molecular Biology	Remnant, EJ Morton, CJ Daborn, PJ Lumb, C Yang, YT Ng, HL Parker, MW Batterham, P
2014	Do current therapeutic anti-A beta antibodies for Alzheimer's disease engage the target? Acta Neuropathologica	Watt, AD Crespi, GAN Down, RA Ascher, DB Gunn, A Perez, KA McLean, CA Villemagne, VL Parker, MW Barnham, KJ Miles, LA
2014	Anti-A beta antibody target engagement: a response to Siemers et al. Acta Neuropathologica	Watt, AD Crespi, GAN Down, RA Ascher, DB Gunn, A Perez, KA McLean, CA Villemagne, VL Parker, MW Barnham, KJ Miles, LA
2014	Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor Science	Brooks, AJ Dai, W O’Mara, ML Abankwa, D Chhabra, Y Pelekanos, RA Gardon, O Tunny, KA Blucher, KM Morton, CJ Parker, MW Sierecki, E Gambin, Y Gomez, GA Alexandrov, K Wilson, IA Doxastakis, M Mark, AE Waters, MJ
2014	Crystallisation and preliminary X-ray diffraction analysis of the Interleukin-3 alpha receptor bound to Fab fragment of antibody Acta Crystallogr F Struct Biol Commun.	Nero, TL Scotney, PD Hercus, TR Fabri, LJ Broughton, SE Hardy, MP Lopez, AF Owczarek, CM Wilson, NJ Dhagat, U Nash, AD Parker, MW
2014	Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362 Acta Crystallographica Section F-structural Biology And Crystallization Communications	Broughton, SE Hercus, TR Nero, TL Dhagat, U Owczarek, CM Hardy, MP Fabri, LJ Scotney, PD Nash, AD Wilson, NJ Lopez, AF Parker, MW
2014	Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of anti Acta Crystallographica Section F-structural Biology Communications	Broughton, SE Hercus, TR Nero, TL Dhagat, U Owczarek, CM Hardy, MP Fabri, LJ Scotney, PD Nash, AD Wilson, NJ Lopez, AF Parker, MW
2014	A Systematic and Functional Classification of Streptococcus pyogenes That Serves as a New Tool for Molecular Typing and Vaccine Development Journal Of Infectious Diseases	Sanderson-Smith, M De Oliveira, DMP Guglielmini, J McMillan, DJ Vu, T Holien, JK Henningham, A Steer, AC Bessen, DE Dale, JB Curtis, N Beall, BW Walker, MJ Parker, MW Carapetis, JR Van Melderen, L Sriprakash, KS Smeesters, PR
2015	Computational analysis of amiloride analogue inhibitors of coxsackievirus B3 RNA polymerase J Proteomics Bioinform	Gazina, EV Parker, MW Holien, JK Williams, SJ Cameron, CE Jarrott, B Elliott, RW Petrou, S
2015	Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form Structure	Parker, MW Linkugel, AD Goel, HL Wu, T Mercurio, AM Vander Kooi, CW
2015	Molecular basis for mid-region amyloid-beta capture by leading Alzheimer's disease immunotherapies Scientific Reports	Crespi, GAN Hermans, SJ Parker, MW Miles, LA
2015	Extracorporeal Membrane Oxygenation as a Bridge to Surgery for Infective Endocarditis Complicated by Aorto-Atrial Fistula and Ca Texas Heart Institute Journal	Noyes, AM Ramu, B Parker, MW Underhill, D
2015	Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9 Bioorganic & Medicinal Chemistry	Phillipson, LJ Segal, DH Nero, TL Parker, MW Wan, SS de Silva, M Guthridge, MA Wei, AH Burns, CJ
2015	Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding Biochemical Journal	Tomlinson, CG Moye, AL Holien, JK Parker, MW Cohen, SB Bryan, TM
2015	Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-truncated Abeta in sporadic Alzheimer disease cases and mouse models Acta Neuropathol.	Bouter, Y Noguerola, JSL Tucholla, P Crespi, GAN Parker, MW Wiltfang, J Miles, LA Bayer, TA
2015	An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin Proceedings Of The National Academy Of Sciences Of The United States Of America	Wade, KR Hotze, EM Kuiper, MJ Morton, CJ Parker, MW Tweten, RK
2015	Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-trunc Acta Neuropathologica	Bouter Y Noguerola JSL Tucholla P Crespi GAN Parker, MW Wiltfang J Miles, LA Bayer TA
2015	Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and effic Journal Of Steroid Biochemistry And Molecular Biology	Martin, LL Holien, JK Mizrachi, D Corbin, CJ Conley, AJ Parker, MW Rodgers, RJ
2015	Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and efficiency J. Steroid Biochem. Mol. Biol.	Martin, LL Holien, JK Mizrachi, D Corbin, CJ Conley, AJ Parker, MW Rodgers, RJ
2015	Crystal structure of the lysine specific protease Kgp, isolated from Porphyromonas gingivalis, a target for improved oral health Protein Sci	Feil, SC Michell, BJ Seers, CA Reynolds, EC Gorman, MA Cross, KJ Huq, NL Parker, MW
2015	Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides Protein Science	Hermans, SJ Ascher, DB Hancock, NC Holien, JK Michell, BJ Chai, SY Morton, CJ Parker, MW
2015	The beta c receptor family - Structural insights and their functional implications Cytokine	Broughton, SE Nero, TL Dhagat, U Kan, WL Hercus, TR Tvorogov, D Lopez, AF Parker, MW
2015	Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase Biochemical Journal	Mobbs, JI Koay, A Di Paolo, A Bieri, M Petrie, EJ Gorman, MA Doughty, L Parker, MW Stapleton, DI Griffin, MD Gooley, PR
2015	Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health Protein Science	Gorman, MA Seers, CA Michell, BJ Feil, SC Huq, NL Cross, KJ Reynolds, EC Parker, MW
2015	Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase Biochem. J.	Mobbs, JI Koay, A Di Paolo, A Bieri, M Petrie, EJ Gorman, MA Doughty, L Parker, MW Stapleton, DI Griffin, MDW Gooley, PR
2015	Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation Sci Rep	Lawrence, SL Feil, SC Morton, CJ Farrand, AJ Mulhern, TD Gorman, MA Wade, KR Tweten, RK Parker, MW
2015	Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation Scientific Reports	Lawrence, S Feil, SC Morton, CJ Farrand, AJ Mulhern, TD Gorman, MA Wade, KR Tweten, RK Parker, MW
2015	Propargyloxyproline Regio- and Stereoisomers for Click-Conjugation of Peptides: Synthesis and Application in Linear and Cyclic P Australian Journal Of Chemistry	Northfield, SE Mountford, SJ Wielens, J Liu, M Zhang, L Herzog, H Holliday, ND Scanlon, MJ Parker, MW Chalmers, DK Thompson, PE
2015	Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1) Plos One	Simonov, AN Holien, JK Yeung, JC Nguyen, AD Corbin, CJ Zheng, J Kuznetsov, VL Auchus, RJ Conley, AJ Bond, AM Parker, MW Rodgers, RJ Martin, LL
2015	Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1) Plos One	Simonov, AN Holien, JK Yeung, JCI Nguyen, AD Corbin, CJ Zheng, J Kuznetsov, VL Auchus, RJ Conley, AJ Bond, AM Parker, MW Rodgers, RJ Martin, LL
2015	Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators Journal Of Experimental Medicine	Flierl, U Nero, TL Lim, B Arthur, JF Yao, Y Jung, SM Gitz, E Pollitt, AY Zaldivia, MTK Jandrot-Perrus, M Schafer, A Nieswandt, B Andrews, RK Parker, MW Gardiner, EE Peter, K
2015	A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production Nature Communications	Nachbur, U Stafford, CA Bankovacki, A Zhan, YF Lindqvist, LM Fiil, BK Khakham, Y Ko, HJ Sandow, JJ Falk, H Holien, JK Chau, D Hildebrand, J Vince, JE Sharp, PP Webb, AI Jackman, KA Muhlen, S Kennedy, CL Lowes, KN Murphy, JM Gyrd-Hansen, M Parker, MW Hartland, EL Lew, AM Huang, DCS Lessene, G Silke, J
2016	The C-terminal extension of human telomerase reverse transcriptase is necessary for high affinity binding to telomeric DNA Biochimie	Tomlinson, CG Holien, JK Mathias, JAT Parker, MW Bryan, TM
2016	Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding Nat. Commun.	Langendorf, CG Ngoei, KRW Scott, JW Ling, NXY Issa, SMA Gorman, MA Parker, MW Sakamoto, K Oakhill, JS Kemp, BE
2016	Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins Structure	Lawrence, SL Gorman, MA Feil, SC Mulhern, TD Kuiper, MJ Ratner, AJ Tweten, RK Morton, CJ Parker, MW
2016	The Binding of Syndapin SH3 Domain to Dynamin Proline-rich Domain Involves Short and Long Distance Elements J. Biol. Chem.	Luo, L Xue, J Kwan, A Gamsjaeger, R Wielens, J von Kleist, L Cubeddu, L Guo, Z Stow, JL Parker, MW Mackay, JP Robinson, PJ
2016	Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling Structure	Broughton, SE Hercus, TR Nero, TL Dottore, M McClure, BJ Dhagat, U Taing, H Gorman, MA King-Scott, J Lopez, AF Parker, MW
2016	Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target Structure	da Costa, TPS Desbois, S Dogovski, C Gorman, MA Ketaren, NE Paxman, JJ Siddiqui, T Zammit, LM Abbott, BM Robins-Browne, RM Parker, MW Jameson, GB Hall, NE Panjikar, S Perugini, MA
2016	CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common beta chain of the IL-3, GM-CSF and IL-5 receptors Mabs	Panousis, C Dhagat, U Edwards, KM Rayzman, V Hardy, MP Braley, H Gauvreau, GM Hercus, TR Smith, S Sehmi, R McMillan, L Dottore, M McClure, BJ Fabri, LJ Vairo, G Lopez, AF Parker, MW Nash, AD Wilson, NJ Wilson, MJ Owczarek, CM
2017	Homodimer Model Can Resolve the Conundrum as to How Cytochrome P450 Oxidoreductase and Cytochrome b5 Compete for the Same Binding Site on Cytochrome P450c17 Curr. Protein Pept. Sci.	Holien, JK Parker, MW Conley, AJ Corbin, CJ Rodgers, RJ Martin, LL
2017	QM/MM simulations provide insight into the mechanism of bioluminescence triggering in ctenophore photoproteins Plos One	Molakarimi, M Mohseni, A Taghdir, M Pashandi, Z Gorman, MA Parker, MW Naderi-Manesh, H Sajedi, RH
2017	Control of Virulence Gene Expression by the Master Regulator, CfaD, in the Prototypical Enterotoxigenic Escherichia coli Strain, H10407 Front. Microbiol.	Hodson, C Yang, J Hocking, DM Azzopardi, K Chen, QY Holien, JK Parker, MW Tauschek, M Robins-Browne, RM
2017	Glutathione transferase P1-1 as an arsenic drug-sequestering enzyme Protein Sci.	Parker, LJ Bocedi, A Ascher, DB Aitken, JB Harris, HH Lo Bello, M Ricci, G Morton, CJ Parker, MW
2017	Ex vivo O-18-labeling mass spectrometry identifies a peripheral amyloid beta clearance pathway Mol. Neurodegener.	Portelius, E Mattsson, N Pannee, J Zetterberg, H Gisslen, M Vanderstichele, H Gkanatsiou, E Crespi, GAN Parker, MW Miles, LA Gobom, J Blennow, K
2017	Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability Nucleic Acids Res.	Gillinder, KR Ilsley, MD Nebor, D Sachidanandam, R Lajoie, M Magor, GW Tallack, MR Bailey, T Landsberg, MJ Mackay, JP Parker, MW Miles, LA Graber, JH Peters, LL Bieker, JJ Perkins, AC
2017	Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites Nat. Commun.	Braig, D Nero, TL Koch, HG Kaiser, B Wang, XW Thiele, JR Morton, CJ Zeller, J Kiefer, J Potempa, LA Mellett, NA Miles, LA Du, XJ Meikle, PJ Huber-Lang, M Stark, GB Parker, MW Peter, K Eisenhardt, SU
2018	Protein structure and computational drug discovery Biochem. Soc. Trans.	Nero, TL Parker, MW Morton, CJ
2018	Nitric Oxide Interacting with Glutathione Transferases	Lo Bello, M Parker, LJ Parker, MW Ricci, G
2018	Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: comment J. Thromb. Haemost.	Flierl, U Nero, TL Lim, B Andrews, RK Parker, MW Gardiner, EE Peter, K
2018	AMP and adenosine are both ligands for adenosine 2B receptor signaling Bioorg. Med. Chem. Lett.	Holien, JK Seibt, B Roberts, V Salvaris, E Parker, MW Cowan, PJ Dwyer, KM
2018	Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase Chemmedchem	Northfield, SE Wielens, J Headey, SJ Williams-Noonan, BJ Mulcair, M Scanlon, MJ Parker, MW Thompson, PE Chalmers, DK
2018	Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis Elife	Marquez, CL Lau, D Walsh, J Shah, V McGuinness, C Wong, A Aggarwal, A Parker, MW Jacques, DA Turville, S Bocking, T
2018	EPO does not promote interaction between the erythropoietin and beta-common receptors Sci Rep	Shing, KSCT Broughton, SE Nero, TL Gillinder, K Ilsley, MD Ramshaw, H Lopez, AF Griffin, MDW Parker, MW Perkins, AC Dhagat, U
2018	Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target Structure	Atkinson, SC Dogovski, C Wood, K Griffin, MDW Gorman, MA Hor, L Reboul, CF Buckle, AM Wuttke, J Parker, MW Dobson, RC Perugini, MA
2018	Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis Sci. Adv.	Tvorogov, D Thomas, D Liau, NPD Dottore, M Barry, EF Lathi, M Kan, WL Hercus, TR Stomski, F Hughes, TP Tergaonkar, V Parker, MW Ross, DM Majeti, R Babon, JJ Lopez, AF
2018	The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities Mabs	Dhagat, U Hercus, TR Broughton, SE Nero, TL Shing, KSCT Barry, EF Thomson, CA Bryson, S Pai, EF McClure, BJ Schrader, JW Lopez, AF Parker, MW
2018	Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4 Cell Chem. Biol.	Ngoei, KRW Langendorf, CG Ling, NXY Hoque, A Varghese, S Camerino, MA Walker, SR Bozikis, YE Dite, TA Ovens, AJ Smiles, WJ Jacobs, R Huang, H Parker, MW Scott, JW Rider, MH Foitzik, RC Kemp, BE Baell, JB Oakhill, JS
2018	A dual role for the N-terminal domain of the IL-3 receptor in cell signalling Nat. Commun.	Broughton, SE Hercus, TR Nero, TL Kan, WL Barry, EF Dottore, M Shing, KSCT Morton, CJ Dhagat, U Hardy, MP Wilson, NJ Downton, MT Schieber, C Hughes, TP Lopez, AF Parker, MW
2018	Role of the beta Common (beta c) Family of Cytokines in Health and Disease Cold Spring Harbor Perspect. Biol.	Hercus, TR Kan, WLT Broughton, SE Tvorogov, D Ramshaw, HS Sandow, JJ Nero, TL Dhagat, U Thompson, EJ Shing, KSCT McKenzie, DR Wilson, NJ Owczarek, CM Vairo, G Nash, AD Tergaonkar, V Hughes, T Ekert, PG Samuel, MS Bonder, CS Grimbaldeston, MA Parker, MW Lopez, AF
2018	Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth Nature	Baell, JB Leaver, DJ Hermans, SJ Kelly, GL Brennan, MS Downer, NL Nguyen, N Wichmann, J Mcrae, HM Yang, YQ Cleary, B Lagiakos, HR Mieruszynski, S Pacini, G Vanyai, HK Bergamasco, MI May, RE Davey, BK Morgan, KJ Sealey, AJ Wang, BN Zamudio, N Wilcox, S Garnham, AL Sheikh, BN Aubrey, BJ Doggett, K Chung, MC de Silva, M Bentley, J Pilling, P Hattarki, M Dolezal, O Dennis, ML Falk, H Ren, B Charman, SA White, KL Rautela, J Newbold, A Hawkins, ED Johnstone, RW Huntington, ND Peat, TS Heath, JK Strasser, A Parker, MW Smyth, GK Street, IP Monahan, BJ Voss, AK Thomas, T
2019	Cholesterol-Dependent Cytolysins: Membrane and Protein Structural Requirements for Pore Formation Chemical Reviews	Morton, CJ Sani, MA Parker, MW Separovic, F
2019	The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease Human Immunology	Hanson, AL Morton, CJ Parker, MW Bessette, D Kenna, TJ
2019	Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals Angewandte Chemie-international Edition	Spackman, PR Yu, LJ Morton, CJ Parker, MW Bond, CS Spackman, MA Jayatilaka, D Thomas, SP
2019	Fluorescence Microscopy Assay to Measure HIV-1 Capsid Uncoating Kinetics in vitro Bio-protocol	Marquez, CL Lau, D Walsh, J Faysal, KMR Parker, MW Turville, SG Bocking, T
2019	Reaction mechanism of the bioluminescent protein mnemiopsin1 revealed by X-ray crystallography and QM/MM simulations J. Biol. Chem.	Molakarimi, M Gorman, MA Mohseni, A Pashandi, Z Taghdir, M Naderi-Manesh, H Sajedi, RH Parker, MW
2019	The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis Nature Microbiology	Xie, SC Metcalfe, RD Hanssen, E Yang, T Gillett, DL Leis, AP Morton, CJ Kuiper, MJ Parker, MW Spillman, NJ Wong, W Tsu, C Dick, LR Griffin, MDW Tilley, L
2019	The structure of the Plasmodium falciparum 20S proteasome in complex with the PA28 activator Acta Crystallographica A-foundation And Advances	Metcalfe, RD Xie, SC Hanssen, E Yang, T Gillett, DL Leis, A Morton, CJ Kuiper, MJ Parker, MW Spillman, NJ Wong, W Tsu, C Dick, LR Griffin, MDW Tilley, L
2019	EPO does not promote interaction between the erythropoietin and beta-common receptors (vol 8, 12457, 2018) Scientific Reports	Shing, KSCT Broughton, SE Nero, TL Gillinder, K Ilsley, MD Ramshaw, H Lopez, AF Griffin, MDW Parker, MW Perkins, AC Dhagat, U
2019	The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin Mbio	Wade, KR Lawrence, SL Farrand, AJ Hotze, EM Kuiper, MJ Gorman, MA Christie, MP Panjikar, S Morton, CJ Parker, MW Tweten, RK
2019	A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1 Proceedings Of The National Academy Of Sciences Of The United States Of America	De Luca, A Parker, LJ Ang, WH Rodolfo, C Gabbarini, V Hancock, NC Palone, F Mazzetti, AP Menin, L Morton, CJ Parker, MW Lo Bello, M Dyson, PJ
2019	A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites Cell Host & Microbe	Sernee, MF Ralton, JE Nero, TL Sobala, LF Kloehn, J Vieira-Lara, MA Cobbold, SA Stanton, L Pires, DEV Hanssen, E Males, A Ward, T Bastidas, LM van der Peet, PL Parker, MW Ascher, DB Williams, SJ Davies, GJ McConville, MJ
2019	Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis Iscience	Miles, LA Hermans, SJ Crespi, GAN Gooi, JH Doughty, L Nero, TL Markulic, J Ebneth, A Wroblowski, B Oehlrich, D Trabanco, AA Rives, ML Royaux, I Hancock, NC Parker, MW
2019	Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth Embo Molecular Medicine	Thilakasiri, P Huynh, J Poh, AR Tan, CW Nero, TL Tran, K Parslow, AC Afshar-Sterle, S Baloyan, D Hannan, NJ Buchert, M Scott, AM Griffin, MDW Hollande, F Parker, MW Putoczki, TL Ernst, M Chand, AL
2019	Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A Journal Of Medicinal Chemistry	Leaver, DJ Cleary, B Nguyen, N Priebbenow, DL Lagiakos, HR Sanchez, J Xue, L Huang, F Sun, YX Mujumdar, P Mudududdla, R Varghese, S Teguh, S Charman, SA White, KL Katneni, K Cuellar, M Strasser, JM Dahlin, JL Walters, MA Street, IP Monahan, BJ Jarman, KE Sabroux, HJ Falk, H Chung, MC Hermans, SJ Parker, MW Thomas, T Baell, JB
2019	Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface Cancer Research	Koach, J Holien, JK Massudi, H Carter, DR Ciampa, OC Herath, M Lim, T Seneviratne, JA Milazzo, G Murray, JE McCarroll, JA Liu, B Mayoh, C Keenan, B Stevenson, BW Gorman, MA Bell, JL Doughty, L Huttelmaier, S Oberthuer, A Fischer, M Gifford, AJ Liu, T Zhang, XL Zhu, SZ Gustafson, WC Haber, M Norris, MD Fletcher, JI Perini, G Parker, MW Cheung, BB Marshall, GM
2020	The Crystal Structure of the Manganese Superoxide Dismutase from Geobacillus stearothermophilus: Parker and Blake (1988) Revisited Australian Journal Of Chemistry	Adams, JJ Morton, CJ Parker, MW
2020	Sequence comparisons of cytochrome P450 aromatases from Australian animals predict differences in enzymatic activity and/or efficiency Biology Of Reproduction	Fatima, A Holien, JK Tiwari, C Parker, MW Rodgers, RJ Martin, LL
2020	A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins Mbio	Evans, JC Johnstone, BA Lawrence, SL Morton, CJ Christie, MP Parker, MW Tweten, RK
2020	A structural view of PA2G4 isoforms with opposing functions in cancer Journal Of Biological Chemistry	Stevenson, BW Gorman, MA Koach, J Cheung, BB Marshall, GM Parker, MW Holien, JK
2020	Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin Plos One	Tan, WN Murphy, VJ Charron, A van Twest, S Sharp, M Constantinou, A Parker, MW Crismani, W Bythell-Douglas, R Deans, AJ
2020	Monoubiquitination by the human Fanconi anemia core complex clamps FANCI: FANCD2 on DNA in filamentous arrays Elife	Tan, W van Twest, S Leis, A Bythell-Douglas, R Murphy, VJ Sharp, M Parker, MW Crismani, W Deans, AJ
2020	The structure of the extracellular domains of human interleukin 11? receptor reveals mechanisms of cytokine engagement Journal Of Biological Chemistry	Metcalfe, RD Aizel, K Zlatic, CO Nguyen, PM Morton, CJ Lio, DSS Cheng, HC Dobson, RCJ Parker, MW Gooley, PR Putoczki, TL Griffin, MDW
2020	CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins Journal Of Biological Chemistry	Langendorf, CG O’Brien, MT Ngoei, KRW McAloon, LM Dhagat, U Hoque, A Ling, NXY Dite, TA Galic, S Loh, K Parker, MW Oakhill, JS Kemp, BE Scott, JW
2020	Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK beta 1 isoforms Nature Metabolism	Pinkosky, SL Scott, JW Desjardins, EM Smith, BK Day, EA Ford, RJ Langendorf, CG Ling, NXY Nero, TL Loh, K Galic, S Hoque, A Smiles, WJ Ngoei, KRW Parker, MW Yan, Y Melcher, K Kemp, BE Oakhill, JS Steinberg, GR
2020	Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents Journal Of Medicinal Chemistry	Priebbenow, DL Leaver, DJ Nguyen, N Cleary, B Lagiakos, HR Sanchez, J Xue, L Huang, F Sun, YX Mujumdar, P Mudududdla, R Varghese, S Teguh, S Charman, SA White, KL Shackleford, DM Katneni, K Cuellar, M Strasser, JM Dahlin, JL Walters, MA Street, IP Monahan, BJ Jarman, KE Sabroux, HJ Falk, H Chung, MC Hermans, SJ Downer, NL Parker, MW Voss, AK Thomas, T Baell, JB
2021	Repurposing of drugs as STAT3 inhibitors for cancer therapy Seminars In Cancer Biology	Thilakasiri, PS Dmello, RS Nero, TL Parker, MW Ernst, M Chand, AL
2021	X-ray crystallography shines a light on pore-forming toxins Pore-forming Toxins	Johnstone, BA Christie, MP Morton, CJ Parker, MW
2021	Messing with beta c: A unique receptor with many goals Seminars In Immunology	Kan, WL Shing, KSCT Nero, TL Hercus, TR Tvorogov, D Parker, MW Lopez, AF
2021	Two-component pore formation by the novel CDCL proteins ALY short and ALY long from Elizabethkingia anophelis Acta Crystallographica A-foundation And Advances	Johnstone, BA Lawrence, SL Morton, CJ Evans, JC Christie, MP Tweten, RK Parker, MW
2021	Structure of native HIV-1 cores and their interactions with IP6 and CypA Science Advances	Ni, T Zhu, YA Yang, ZY Xu, CY Chaban, Y Nesterova, T Ning, JY Bocking, T Parker, MW Monnie, C Ahn, J Perilla, JR Zhang, PJ
2021	Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster Insect Biochemistry And Molecular Biology	Perry, T Chen, W Ghazali, R Yang, YT Christesen, D Martelli, F Lumb, C Luong, HNB Mitchell, J Holien, JK Parker, MW Sparks, TC Batterham, P
2021	An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability Nature Communications	Nagy, Z Seneviratne, JA Kanikevich, M Chang, W Mayoh, C Venkat, P Du, YH Jiang, CZ Salib, A Koach, J Carter, DR Mittra, R Liu, T Parker, MW Cheung, BB Marshall, GM
2021	Development of [F-18]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease European Journal Of Medicinal Chemistry	Wong, SW Vivash, L Mudududdla, R Nguyen, N Hermans, SJ Shackleford, DM Field, J Xue, L Aprico, A Hancock, NC Haskali, M Stashko, MA Frye, SV Wang, XD Binder, MD Ackermann, U Parker, MW Kilpatrick, TJ Baell, JB
2021	Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome Journal Of Allergy And Clinical Immunology	Chen, YH Zastrow, DB Metcalfe, RD Gartner, L Krause, F Morton, CJ Marwaha, S Fresard, L Huang, Y Zhao, CL McCormack, C Bick, D Worthey, EA Eng, CM Gold, J Montgomery, SB Fisher, PG Ashley, EA Wheeler, MT Parker, MW Shanmugasundaram, V Putoczki, TL Schmidt-Arras, D Laurence, A Bernstein, JA Griffin, MDW Uhlig, HH
2021	A DARPin targeting activated Mac-1 is a novel diagnostic tool and potential anti-inflammatory agent in myocarditis, sepsis and myocardial infarction Basic Research In Cardiology	Siegel, PM Bojti, I Bassler, N Holien, J Flierl, U Wang, XW Waggershauser, P Tonnar, X Vedecnik, C Lamprecht, C Stankova, I Li, T Helbing, T Wolf, D Anto-Michel, N Mitre, LS Ehrlich, J Orlean, L Bender, I Przewosnik, A Mauler, M Hollederer, L Moser, M Bode, C Parker, MW Peter, K Diehl, P
2021	A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma Oncogene	Cheung, BB Kleynhans, A Mittra, R Kim, PY Holien, JK Nagy, Z Ciampa, OC Seneviratne, JA Mayoh, C Raipuria, M Gadde, S Massudi, H Wong, IPL Tan, O Gong, A Suryano, A Diakiw, SM Liu, B Arndt, GM Liu, T Kumar, N Sangfelt, O Zhu, SZ Norris, MD Haber, M Carter, DR Parker, MW Marshall, GM
2021	Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome Proceedings Of The National Academy Of Sciences Of The United States Of America	Xie, SC Metcalfe, RD Mizutani, H Puhalovich, T Hanssen, E Morton, CJ Du, YW Dogovski, C Huang, SC Ciavarri, J Hales, P Griffin, RJ Cohen, LH Chuang, BC Wittlin, S Deni, I Yeo, T Ward, KE Barry, DC Liu, BY Gillett, DL Crespo-Fernandez, BF Ottilie, S Mittal, N Churchyard, A Ferguson, D Aguiar, ACC Guido, RVC Baum, J Hanson, KK Winzeler, EA Gamo, FJ Fidock, DA Baud, D Parker, MW Brand, S Dick, LR Griffin, MDW Gould, AE Tilley, L
2022	Single-molecule analysis of the entire perfringolysin O pore formation pathway Elife	Mc Guinness, C Walsh, JC Bayly-Jones, C Dunstone, MA Christie, MP Morton, CJ Parker, MW Bocking, T
2022	Heparin Inhibits SARS-CoV-2 Replication in Human Nasal Epithelial Cells Viruses-basel	Lee, LYY Suryadinata, R McCafferty, C Ignjatovic, V Purcell, DFJ Robinson, P Morton, CJ Parker, MW Anderson, GP Monagle, P Subbarao, K Neil, JA
2022	C-reactive protein, immunothrombosis and venous thromboembolism Frontiers In Immunology	Dix, C Zeller, J Stevens, H Eisenhardt, SU Shing, KSCT Nero, TL Morton, CJ Parker, MW Peter, K McFadyen, JD
2022	Cholesterol-dependent cytolysins: The outstanding questions Iubmb Life	Johnstone, BA Joseph, R Christie, MP Morton, CJ McGuiness, C Walsh, JC Bocking, T Tweten, RK Parker, MW
2022	Transitional changes in the structure of C-reactive protein create highly pro-inflammatory molecules: Therapeutic implications for cardiovascular diseases Pharmacology & Therapeutics	Zeller, J Bogner, B McFadyen, JD Kiefer, J Braig, D Pietersz, G Krippner, G Nero, TL Morton, CJ Shing, KSCT Parker, MW Peter, K Eisenhardt, SU
2022	Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator Biochemical Journal	Ovens, AJ Gee, YS Ling, NXY Yu, DY Hardee, JP Chung, JD Ngoei, KRW Waters, NJ Hoffman, NJ Scott, JW Loh, K Spengler, K Heller, R Parker, MW Lynch, GS Huang, F Galic, S Kemp, BE Baell, JB Oakhill, JS Langendorf, CG
2022	Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability Proceedings Of The National Academy Of Sciences Of The United States Of America	Hodson, C Low, JKK van Twest, S Jones, SE Swuec, P Murphy, V Tsukada, K Fawkes, M Bythell-Douglas, R Davies, A Holien, JK O’Rourke, JJ Parker, BL Glaser, A Parker, MW Mackay, JP Blackford, AN Costa, A Deans, AJ
2022	Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia Cell Metabolism	Morrow, MR Batchuluun, B Wu, JH Ahmadi, E Leroux, JM Mohammadi-Shemirani, P Desjardins, EM Wang, ZC Tsakiridis, EE Lavoie, DCT Reihani, A Smith, BK Kwiecien, JM Lally, JSV Nero, TL Parker, MW Ask, K Scott, JW Jiang, L Pare, G Pinkosky, SL Steinberg, GR
2023	Translating the biology of B common receptor- engaging cytokines into clinical medicine Journal Of Allergy And Clinical Immunology	Pant, H Hercus, TR Tumes, DJ Yip, KH Parker, MW Owczarek, CM Lopez, AF Huston, DP
2023	Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography Chemical Communications	Dickmann, CGF McDonald, AF Huynh, N Rigopoulos, A Liu, ZQ Guo, NY Osellame, LD Gorman, MA Parker, MW Gan, HK Scott, AM Ackermann, U Burvenich, IJG White, JM
2023	Inhibitors of the Oncogenic PA2G4-MYCN Protein-Protein Interface Cancers	Massudi, H Luo, JS Holien, JK Gadde, S Krishan, S Herath, M Koach, J Stevenson, BW Gorman, MA Venkat, P Mayoh, C Luo, XQ Parker, MW Cheung, BB Marshall, GM
2023	A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein Embo Molecular Medicine	Zeller, J Shing, KSCT Nero, TL McFadyen, JD Krippner, G Bogner, B Kreuzaler, S Kiefer, J Horner, VK Braig, D Danish, H Baratchi, S Fricke, M Wang, XW Kather, MG Kammerer, B Woollard, KJ Sharma, P Morton, CJ Pietersz, G Parker, MW Peter, K Eisenhardt, SU