Title: Crystal structure of the lysine specific protease Kgp, isolated from Porphyromonas gingivalis, a target for improved oral health
Authors: Feil, SC
Michell, BJ
Seers, CA
Gorman, MA
Reynolds, EC
Cross, KJ
Huq, NL
Parker, MW
Issue Year: 2015
Publisher
Series Protein Sci:
Abstract The oral pathogen Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Gingipains, the principle virulence factors of P. gingivalis are multidomain, cell-surface proteins containing a cysteine protease domain. The lysine specific gingipain, Kgp, is a critical virulence factor of P. gingivalis. We have determined the X-ray crystal structure of the lysine-specific protease domain of Kgp to 1.6 Å resolution. The structure provides insights into the mechanism of substrate specificity and catalysis.
URI: https://publications.svi.edu.au/publications/2413
ISSN
Other Identifiers 24(1):162-6
Publication type Article
Grant ID GNT1021645; GNT1081252
Find it online https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282422/