Title: Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health
Authors: Gorman, MA
Seers, CA
Michell, BJ
Feil, SC
Huq, NL
Cross, KJ
Reynolds, EC
Parker, MW
Issue Year: 2015
Publisher WILEY-BLACKWELL
Series PROTEIN SCIENCE: 24(1): 162-166
Abstract The oral pathogen Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Gingipains, the principle virulence factors of P. gingivalis are multidomain, cell-surface proteins containing a cysteine protease domain. The lysine specific gingipain, Kgp, is a critical virulence factor of P. gingivalis. We have determined the X-ray crystal structure of the lysine-specific protease domain of Kgp to 1.6 angstrom resolution. The structure provides insights into the mechanism of substrate specificity and catalysis.
URI: https://publications.svi.edu.au/publications/1815
ISSN 0961-8368
Other Identifiers 10.1002/pro.2589
Publication type Article
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