Publications by Researcher: Morton, CJ

Year	Title	Author(s)
2012	An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus Acs Medicinal Chemistry Letters	Feil, SC Hamilton, S Krippner, GY Lin, B Luttick, A McConnell, DB Nearn, R Parker, MW Ryan, J Stanislawski, PC Tucker, SP Watson, KG Morton, CJ
2014	The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster Insect Biochemistry And Molecular Biology	Remnant, EJ Morton, CJ Daborn, PJ Lumb, C Yang, YT Ng, HL Parker, MW Batterham, P
2014	Oncogenic protein interfaces: small molecules, big challenges Nature Reviews Cancer	Nero, TL Morton, CJ Holien, JK Wielens, J Parker, MW
2014	Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA Scientific Reports	Ascher, DB Wielens, J Nero, TL Doughty, L Morton, CJ Parker, MW
2014	Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor Science	Brooks, AJ Dai, W O’Mara, ML Abankwa, D Chhabra, Y Pelekanos, RA Gardon, O Tunny, KA Blucher, KM Morton, CJ Parker, MW Sierecki, E Gambin, Y Gomez, GA Alexandrov, K Wilson, IA Doxastakis, M Mark, AE Waters, MJ
2015	Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation Scientific Reports	Lawrence, S Feil, SC Morton, CJ Farrand, AJ Mulhern, TD Gorman, MA Wade, KR Tweten, RK Parker, MW
2015	Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation Sci Rep	Lawrence, SL Feil, SC Morton, CJ Farrand, AJ Mulhern, TD Gorman, MA Wade, KR Tweten, RK Parker, MW
2015	An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin Proceedings Of The National Academy Of Sciences Of The United States Of America	Wade, KR Hotze, EM Kuiper, MJ Morton, CJ Parker, MW Tweten, RK
2015	Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides Protein Science	Hermans, SJ Ascher, DB Hancock, NC Holien, JK Michell, BJ Chai, SY Morton, CJ Parker, MW
2016	Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins Structure	Lawrence, SL Gorman, MA Feil, SC Mulhern, TD Kuiper, MJ Ratner, AJ Tweten, RK Morton, CJ Parker, MW
2017	Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites Nat. Commun.	Braig, D Nero, TL Koch, HG Kaiser, B Wang, XW Thiele, JR Morton, CJ Zeller, J Kiefer, J Potempa, LA Mellett, NA Miles, LA Du, XJ Meikle, PJ Huber-Lang, M Stark, GB Parker, MW Peter, K Eisenhardt, SU
2017	Glutathione transferase P1-1 as an arsenic drug-sequestering enzyme Protein Sci.	Parker, LJ Bocedi, A Ascher, DB Aitken, JB Harris, HH Lo Bello, M Ricci, G Morton, CJ Parker, MW
2017	Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1 Plos One	Mohanty, B Rimmer, K McMahon, RM Headey, SJ Vazirani, M Shouldice, SR Coincon, M Tay, S Morton, CJ Simpson, JS Martin, JL Scanlon, MJ
2018	Protein structure and computational drug discovery Biochem. Soc. Trans.	Nero, TL Parker, MW Morton, CJ
2018	Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile Arthritis Rheumatol.	Hanson, AL Cuddihy, T Haynes, K Loo, D Morton, CJ Oppermann, U Leo, P Thomas, GP Cao, KAL Kenna, TJ Brown, MA
2018	Characterization of Tfrc-mutant mice with microcytic phenotypes Blood Adv.	Conway, AJ Brown, FC Rank, G Kile, BT Morton, CJ Jane, SM Curtis, DJ
2018	Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency Dis. Model. Mech.	Conway, AJ Brown, FC Hortle, EJ Burgio, G Foote, SJ Morton, CJ Jane, SM Curti, DJ
2018	A dual role for the N-terminal domain of the IL-3 receptor in cell signalling Nat. Commun.	Broughton, SE Hercus, TR Nero, TL Kan, WL Barry, EF Dottore, M Shing, KSCT Morton, CJ Dhagat, U Hardy, MP Wilson, NJ Downton, MT Schieber, C Hughes, TP Lopez, AF Parker, MW
2019	Cholesterol-Dependent Cytolysins: Membrane and Protein Structural Requirements for Pore Formation Chemical Reviews	Morton, CJ Sani, MA Parker, MW Separovic, F
2019	The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease Human Immunology	Hanson, AL Morton, CJ Parker, MW Bessette, D Kenna, TJ
2019	Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals Angewandte Chemie-international Edition	Spackman, PR Yu, LJ Morton, CJ Parker, MW Bond, CS Spackman, MA Jayatilaka, D Thomas, SP
2019	The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis Nature Microbiology	Xie, SC Metcalfe, RD Hanssen, E Yang, T Gillett, DL Leis, AP Morton, CJ Kuiper, MJ Parker, MW Spillman, NJ Wong, W Tsu, C Dick, LR Griffin, MDW Tilley, L
2019	The structure of the Plasmodium falciparum 20S proteasome in complex with the PA28 activator Acta Crystallographica A-foundation And Advances	Metcalfe, RD Xie, SC Hanssen, E Yang, T Gillett, DL Leis, A Morton, CJ Kuiper, MJ Parker, MW Spillman, NJ Wong, W Tsu, C Dick, LR Griffin, MDW Tilley, L
2019	The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin Mbio	Wade, KR Lawrence, SL Farrand, AJ Hotze, EM Kuiper, MJ Gorman, MA Christie, MP Panjikar, S Morton, CJ Parker, MW Tweten, RK
2019	A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1 Proceedings Of The National Academy Of Sciences Of The United States Of America	De Luca, A Parker, LJ Ang, WH Rodolfo, C Gabbarini, V Hancock, NC Palone, F Mazzetti, AP Menin, L Morton, CJ Parker, MW Lo Bello, M Dyson, PJ
2020	The Crystal Structure of the Manganese Superoxide Dismutase from Geobacillus stearothermophilus: Parker and Blake (1988) Revisited Australian Journal Of Chemistry	Adams, JJ Morton, CJ Parker, MW
2020	A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins Mbio	Evans, JC Johnstone, BA Lawrence, SL Morton, CJ Christie, MP Parker, MW Tweten, RK
2020	The structure of the extracellular domains of human interleukin 11? receptor reveals mechanisms of cytokine engagement Journal Of Biological Chemistry	Metcalfe, RD Aizel, K Zlatic, CO Nguyen, PM Morton, CJ Lio, DSS Cheng, HC Dobson, RCJ Parker, MW Gooley, PR Putoczki, TL Griffin, MDW
2021	Two-component pore formation by the novel CDCL proteins ALY short and ALY long from Elizabethkingia anophelis Acta Crystallographica A-foundation And Advances	Johnstone, BA Lawrence, SL Morton, CJ Evans, JC Christie, MP Tweten, RK Parker, MW
2021	X-ray crystallography shines a light on pore-forming toxins Pore-forming Toxins	Johnstone, BA Christie, MP Morton, CJ Parker, MW
2021	Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome Journal Of Allergy And Clinical Immunology	Chen, YH Zastrow, DB Metcalfe, RD Gartner, L Krause, F Morton, CJ Marwaha, S Fresard, L Huang, Y Zhao, CL McCormack, C Bick, D Worthey, EA Eng, CM Gold, J Montgomery, SB Fisher, PG Ashley, EA Wheeler, MT Parker, MW Shanmugasundaram, V Putoczki, TL Schmidt-Arras, D Laurence, A Bernstein, JA Griffin, MDW Uhlig, HH
2021	Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome Proceedings Of The National Academy Of Sciences Of The United States Of America	Xie, SC Metcalfe, RD Mizutani, H Puhalovich, T Hanssen, E Morton, CJ Du, YW Dogovski, C Huang, SC Ciavarri, J Hales, P Griffin, RJ Cohen, LH Chuang, BC Wittlin, S Deni, I Yeo, T Ward, KE Barry, DC Liu, BY Gillett, DL Crespo-Fernandez, BF Ottilie, S Mittal, N Churchyard, A Ferguson, D Aguiar, ACC Guido, RVC Baum, J Hanson, KK Winzeler, EA Gamo, FJ Fidock, DA Baud, D Parker, MW Brand, S Dick, LR Griffin, MDW Gould, AE Tilley, L
2022	Cholesterol-dependent cytolysins: The outstanding questions Iubmb Life	Johnstone, BA Joseph, R Christie, MP Morton, CJ McGuiness, C Walsh, JC Bocking, T Tweten, RK Parker, MW
2022	Single-molecule analysis of the entire perfringolysin O pore formation pathway Elife	Mc Guinness, C Walsh, JC Bayly-Jones, C Dunstone, MA Christie, MP Morton, CJ Parker, MW Bocking, T
2022	C-reactive protein, immunothrombosis and venous thromboembolism Frontiers In Immunology	Dix, C Zeller, J Stevens, H Eisenhardt, SU Shing, KSCT Nero, TL Morton, CJ Parker, MW Peter, K McFadyen, JD
2022	Heparin Inhibits SARS-CoV-2 Replication in Human Nasal Epithelial Cells Viruses-basel	Lee, LYY Suryadinata, R McCafferty, C Ignjatovic, V Purcell, DFJ Robinson, P Morton, CJ Parker, MW Anderson, GP Monagle, P Subbarao, K Neil, JA
2022	Transitional changes in the structure of C-reactive protein create highly pro-inflammatory molecules: Therapeutic implications for cardiovascular diseases Pharmacology & Therapeutics	Zeller, J Bogner, B McFadyen, JD Kiefer, J Braig, D Pietersz, G Krippner, G Nero, TL Morton, CJ Shing, KSCT Parker, MW Peter, K Eisenhardt, SU
2023	A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein Embo Molecular Medicine	Zeller, J Shing, KSCT Nero, TL McFadyen, JD Krippner, G Bogner, B Kreuzaler, S Kiefer, J Horner, VK Braig, D Danish, H Baratchi, S Fricke, M Wang, XW Kather, MG Kammerer, B Woollard, KJ Sharma, P Morton, CJ Pietersz, G Parker, MW Peter, K Eisenhardt, SU