Publications by Researcher: Morton, CJ

YearTitleAuthor(s)
2012 An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus
Acs Medicinal Chemistry Letters
Feil, SC Hamilton, S Krippner, GY Lin, B Luttick, A McConnell, DB Nearn, R Parker, MW Ryan, J Stanislawski, PC Tucker, SP Watson, KG Morton, CJ
2014 Oncogenic protein interfaces: small molecules, big challenges
Nature Reviews Cancer
Nero, TL Morton, CJ Holien, JK Wielens, J Parker, MW
2014 The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster
Insect Biochemistry And Molecular Biology
Remnant, EJ Morton, CJ Daborn, PJ Lumb, C Yang, YT Ng, HL Parker, MW Batterham, P
2014 Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
Scientific Reports
Ascher, DB Wielens, J Nero, TL Doughty, L Morton, CJ Parker, MW
2014 Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor
Science
Brooks, AJ Dai, W O’Mara, ML Abankwa, D Chhabra, Y Pelekanos, RA Gardon, O Tunny, KA Blucher, KM Morton, CJ Parker, MW Sierecki, E Gambin, Y Gomez, GA Alexandrov, K Wilson, IA Doxastakis, M Mark, AE Waters, MJ
2015 Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation
Sci Rep
Lawrence, SL Feil, SC Morton, CJ Farrand, AJ Mulhern, TD Gorman, MA Wade, KR Tweten, RK Parker, MW
2015 Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation
Scientific Reports
Lawrence, S Feil, SC Morton, CJ Farrand, AJ Mulhern, TD Gorman, MA Wade, KR Tweten, RK Parker, MW
2015 An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin
Proceedings Of The National Academy Of Sciences Of The United States Of America
Wade, KR Hotze, EM Kuiper, MJ Morton, CJ Parker, MW Tweten, RK
2015 Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides
Protein Science
Hermans, SJ Ascher, DB Hancock, NC Holien, JK Michell, BJ Chai, SY Morton, CJ Parker, MW
2016 Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins
Structure
Lawrence, SL Gorman, MA Feil, SC Mulhern, TD Kuiper, MJ Ratner, AJ Tweten, RK Morton, CJ Parker, MW
2017 Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites
Nat. Commun.
Braig, D Nero, TL Koch, HG Kaiser, B Wang, XW Thiele, JR Morton, CJ Zeller, J Kiefer, J Potempa, LA Mellett, NA Miles, LA Du, XJ Meikle, PJ Huber-Lang, M Stark, GB Parker, MW Peter, K Eisenhardt, SU
2017 Glutathione transferase P1-1 as an arsenic drug-sequestering enzyme
Protein Sci.
Parker, LJ Bocedi, A Ascher, DB Aitken, JB Harris, HH Lo Bello, M Ricci, G Morton, CJ Parker, MW
2017 Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1
Plos One
Mohanty, B Rimmer, K McMahon, RM Headey, SJ Vazirani, M Shouldice, SR Coincon, M Tay, S Morton, CJ Simpson, JS Martin, JL Scanlon, MJ
2018 Protein structure and computational drug discovery
Biochem. Soc. Trans.
Nero, TL Parker, MW Morton, CJ
2018 Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile
Arthritis Rheumatol.
Hanson, AL Cuddihy, T Haynes, K Loo, D Morton, CJ Oppermann, U Leo, P Thomas, GP Cao, KAL Kenna, TJ Brown, MA
2018 Characterization of Tfrc-mutant mice with microcytic phenotypes
Blood Adv.
Conway, AJ Brown, FC Rank, G Kile, BT Morton, CJ Jane, SM Curtis, DJ
2018 Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency
Dis. Model. Mech.
Conway, AJ Brown, FC Hortle, EJ Burgio, G Foote, SJ Morton, CJ Jane, SM Curti, DJ
2018 A dual role for the N-terminal domain of the IL-3 receptor in cell signalling
Nat. Commun.
Broughton, SE Hercus, TR Nero, TL Kan, WL Barry, EF Dottore, M Shing, KSCT Morton, CJ Dhagat, U Hardy, MP Wilson, NJ Downton, MT Schieber, C Hughes, TP Lopez, AF Parker, MW
2019 Cholesterol-Dependent Cytolysins: Membrane and Protein Structural Requirements for Pore Formation
Chemical Reviews
Morton, CJ Sani, MA Parker, MW Separovic, F
2019 The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease
Human Immunology
Hanson, AL Morton, CJ Parker, MW Bessette, D Kenna, TJ
2019 Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals
Angewandte Chemie-international Edition
Spackman, PR Yu, LJ Morton, CJ Parker, MW Bond, CS Spackman, MA Jayatilaka, D Thomas, SP
2019 The structure of the Plasmodium falciparum 20S proteasome in complex with the PA28 activator
Acta Crystallographica A-foundation And Advances
Metcalfe, RD Xie, SC Hanssen, E Yang, T Gillett, DL Leis, A Morton, CJ Kuiper, MJ Parker, MW Spillman, NJ Wong, W Tsu, C Dick, LR Griffin, MDW Tilley, L
2019 The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis
Nature Microbiology
Xie, SC Metcalfe, RD Hanssen, E Yang, T Gillett, DL Leis, AP Morton, CJ Kuiper, MJ Parker, MW Spillman, NJ Wong, W Tsu, C Dick, LR Griffin, MDW Tilley, L
2019 The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin
Mbio
Wade, KR Lawrence, SL Farrand, AJ Hotze, EM Kuiper, MJ Gorman, MA Christie, MP Panjikar, S Morton, CJ Parker, MW Tweten, RK
2019 A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1
Proceedings Of The National Academy Of Sciences Of The United States Of America
De Luca, A Parker, LJ Ang, WH Rodolfo, C Gabbarini, V Hancock, NC Palone, F Mazzetti, AP Menin, L Morton, CJ Parker, MW Lo Bello, M Dyson, PJ
2020 The Crystal Structure of the Manganese Superoxide Dismutase from Geobacillus stearothermophilus: Parker and Blake (1988) Revisited
Australian Journal Of Chemistry
Adams, JJ Morton, CJ Parker, MW
2020 A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins
Mbio
Evans, JC Johnstone, BA Lawrence, SL Morton, CJ Christie, MP Parker, MW Tweten, RK
2020 The structure of the extracellular domains of human interleukin 11? receptor reveals mechanisms of cytokine engagement
Journal Of Biological Chemistry
Metcalfe, RD Aizel, K Zlatic, CO Nguyen, PM Morton, CJ Lio, DSS Cheng, HC Dobson, RCJ Parker, MW Gooley, PR Putoczki, TL Griffin, MDW