Publications by Researcher: Lopez, AF

Year	Title	Author(s)
2012	Cytokine receptor activation at the cell surface Current Opinion In Structural Biology	Broughton, SE Hercus, TR Lopez, AF Parker, MW
2012	The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling Immunological Reviews	Broughton, SE Dhagat, U Hercus, TR Nero, TL Grimbaldeston, MA Bonder, CS Lopez, AF Parker, MW
2012	The GM-CSF receptor family: Mechanism of activation and implications for disease Growth Factors	Hercus, TR Broughton, SE Ekert, PG Ramshaw, HS Perugini, M Grimbaldeston, M Woodcock, JM Thomas, D Pitson, S Hughes, T D’Andrea, RJ Parker, MW Lopez, AF
2013	Signalling by the beta c family of cytokines Cytokine & Growth Factor Reviews	Hercus, TR Dhagat, U Kan, WLT Broughton, SE Nero, TL Perugini, M Sandow, JJ D’Andrea, RJ Ekert, PG Hughes, T Parker, MW Lopez, AF
2013	Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription Blood	Thomas, D Powell, JA Vergez, F Segal, DH Nguyen, NYN Baker, A Teh, TC Barry, EF Sarry, JE Lee, EM Nero, TL Jabbour, AM Pomilio, G Green, BD Manenti, S Glaser, SP Parker, MW Lopez, AF Ekert, PG Lock, RB Huang, DCS Nilsson, SK Recher, C Wei, AH Guthridge, MA
2014	Crystallisation and preliminary X-ray diffraction analysis of the Interleukin-3 alpha receptor bound to Fab fragment of antibody Acta Crystallogr F Struct Biol Commun.	Hercus, TR Fabri, LJ Broughton, SE Hardy, MP Lopez, AF Owczarek, CM Wilson, NJ Dhagat, U Nash, AD Nero, TL Scotney, PD Parker, MW
2014	Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362 Acta Crystallographica Section F-structural Biology And Crystallization Communications	Broughton, SE Hercus, TR Nero, TL Dhagat, U Owczarek, CM Hardy, MP Fabri, LJ Scotney, PD Nash, AD Wilson, NJ Lopez, AF Parker, MW
2014	Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of anti Acta Crystallographica Section F-structural Biology Communications	Broughton, SE Hercus, TR Nero, TL Dhagat, U Owczarek, CM Hardy, MP Fabri, LJ Scotney, PD Nash, AD Wilson, NJ Lopez, AF Parker, MW
2014	Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody. Cell Rep	McClure, BJ Kan, WL Owczarek, CM Broughton, SE Barry, EF Busfield, SJ Hardy, MP Braley, H Hartman, D Parker, MW Hercus, TR Huynh, H Scotney, PD Wilson, NJ Dottore, M Dhagat, U Nash, AD Lopez, AF
2015	The beta c receptor family - Structural insights and their functional implications Cytokine	Broughton, SE Nero, TL Dhagat, U Kan, WL Hercus, TR Tvorogov, D Lopez, AF Parker, MW
2016	Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling Structure	Broughton, SE Hercus, TR Nero, TL Dottore, M McClure, BJ Dhagat, U Taing, H Gorman, MA King-Scott, J Lopez, AF Parker, MW
2016	CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common beta chain of the IL-3, GM-CSF and IL-5 receptors Mabs	Panousis, C Dhagat, U Edwards, KM Rayzman, V Hardy, MP Braley, H Gauvreau, GM Hercus, TR Smith, S Sehmi, R McMillan, L Dottore, M McClure, BJ Fabri, LJ Vairo, G Lopez, AF Parker, MW Nash, AD Wilson, NJ Wilson, MJ Owczarek, CM
2018	EPO does not promote interaction between the erythropoietin and beta-common receptors Sci Rep	Shing, KSCT Broughton, SE Nero, TL Gillinder, K Ilsley, MD Ramshaw, H Lopez, AF Griffin, MDW Parker, MW Perkins, AC Dhagat, U
2018	The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities Mabs	Dhagat, U Hercus, TR Broughton, SE Nero, TL Shing, KSCT Barry, EF Thomson, CA Bryson, S Pai, EF McClure, BJ Schrader, JW Lopez, AF Parker, MW
2018	A dual role for the N-terminal domain of the IL-3 receptor in cell signalling Nat. Commun.	Broughton, SE Hercus, TR Nero, TL Kan, WL Barry, EF Dottore, M Shing, KSCT Morton, CJ Dhagat, U Hardy, MP Wilson, NJ Downton, MT Schieber, C Hughes, TP Lopez, AF Parker, MW
2018	Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis Sci. Adv.	Tvorogov, D Thomas, D Liau, NPD Dottore, M Barry, EF Lathi, M Kan, WL Hercus, TR Stomski, F Hughes, TP Tergaonkar, V Parker, MW Ross, DM Majeti, R Babon, JJ Lopez, AF
2018	Role of the beta Common (beta c) Family of Cytokines in Health and Disease Cold Spring Harbor Perspect. Biol.	Hercus, TR Kan, WLT Broughton, SE Tvorogov, D Ramshaw, HS Sandow, JJ Nero, TL Dhagat, U Thompson, EJ Shing, KSCT McKenzie, DR Wilson, NJ Owczarek, CM Vairo, G Nash, AD Tergaonkar, V Hughes, T Ekert, PG Samuel, MS Bonder, CS Grimbaldeston, MA Parker, MW Lopez, AF
2019	EPO does not promote interaction between the erythropoietin and beta-common receptors (vol 8, 12457, 2018) Scientific Reports	Shing, KSCT Broughton, SE Nero, TL Gillinder, K Ilsley, MD Ramshaw, H Lopez, AF Griffin, MDW Parker, MW Perkins, AC Dhagat, U
2021	Messing with beta c: A unique receptor with many goals Seminars In Immunology	Kan, WL Shing, KSCT Nero, TL Hercus, TR Tvorogov, D Parker, MW Lopez, AF
2023	Translating the biology of B common receptor- engaging cytokines into clinical medicine Journal Of Allergy And Clinical Immunology	Pant, H Hercus, TR Tumes, DJ Yip, KH Parker, MW Owczarek, CM Lopez, AF Huston, DP