Title: Role of the beta Common (beta c) Family of Cytokines in Health and Disease
Authors: Hercus, TR
Kan, WLT
Broughton, SE
Tvorogov, D
Ramshaw, HS
Sandow, JJ
Nero, TL
Dhagat, U
Thompson, EJ
Shing, KSCT
McKenzie, DR
Wilson, NJ
Owczarek, CM
Vairo, G
Nash, AD
Tergaonkar, V
Hughes, T
Ekert, PG
Samuel, MS
Bonder, CS
Grimbaldeston, MA
Parker, MW
Lopez, AF
Issue Year: 2018
Series Cold Spring Harbor Perspect. Biol.:
Abstract The beta common ([beta c]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which use beta c as their key signaling receptor subunit. This is a prototypic signaling subunit-sharing cytokine family that has unveiled many biological paradigms and structural principles applicable to the IL-2, IL-4, and IL-6 receptor families, all of which also share one or more signaling subunits. Originally identified for their functions in the hematopoietic system, the beta c cytokines are now known to be truly pleiotropic, impacting on multiple cell types, organs, and biological systems, and thereby controlling the balance between health and disease. This review will focus on the emerging biological roles for the beta c cytokines, our progress toward understanding the mechanisms of receptor assembly and signaling, and the application of this knowledge to develop exciting new therapeutic approaches against human disease.
URI: https://publications.svi.edu.au/publications/4491
Other Identifiers 10.1101/cshperspect.a028514
Publication type Article