Publications by Researcher: Hercus, TR

YearTitleAuthor(s)
2012 The GM-CSF receptor family: Mechanism of activation and implications for disease
Growth Factors
Hercus, TR Broughton, SE Ekert, PG Ramshaw, HS Perugini, M Grimbaldeston, M Woodcock, JM Thomas, D Pitson, S Hughes, T D’Andrea, RJ Parker, MW Lopez, AF
2012 Cytokine receptor activation at the cell surface
Current Opinion In Structural Biology
Broughton, SE Hercus, TR Lopez, AF Parker, MW
2012 The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling
Immunological Reviews
Broughton, SE Dhagat, U Hercus, TR Nero, TL Grimbaldeston, MA Bonder, CS Lopez, AF Parker, MW
2013 Signalling by the beta c family of cytokines
Cytokine & Growth Factor Reviews
Hercus, TR Dhagat, U Kan, WLT Broughton, SE Nero, TL Perugini, M Sandow, JJ D’Andrea, RJ Ekert, PG Hughes, T Parker, MW Lopez, AF
2013 Characterization of pathogenic human monoclonal autoantibodies against GM-CSF
Proceedings Of The National Academy Of Sciences Of The United States Of America
Wang, YN Thomson, CA Allan, LL Jackson, LM Olson, M Hercus, TR Nero, TL Turner, A Parker, MW Lopez, AL Waddell, TK Anderson, GP Hamilton, JA Schrader, JW
2014 Crystallisation and preliminary X-ray diffraction analysis of the Interleukin-3 alpha receptor bound to Fab fragment of antibody
Acta Crystallogr F Struct Biol Commun.
Nash, AD Nero, TL Scotney, PD Hercus, TR Fabri, LJ Broughton, SE Hardy, MP Lopez, AF Owczarek, CM Wilson, NJ Dhagat, U Parker, MW
2014 Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody.
Cell Rep
Scotney, PD Dottore, M Dhagat, U Nash, AD McClure, BJ Kan, WL Owczarek, CM Broughton, SE Barry, EF Busfield, SJ Wilson, NJ Hardy, MP Braley, H Hartman, D Parker, MW Hercus, TR Huynh, H Lopez, AF
2014 Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362
Acta Crystallographica Section F-structural Biology And Crystallization Communications
Broughton, SE Hercus, TR Nero, TL Dhagat, U Owczarek, CM Hardy, MP Fabri, LJ Scotney, PD Nash, AD Wilson, NJ Lopez, AF Parker, MW
2014 Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of anti
Acta Crystallographica Section F-structural Biology Communications
Broughton, SE Hercus, TR Nero, TL Dhagat, U Owczarek, CM Hardy, MP Fabri, LJ Scotney, PD Nash, AD Wilson, NJ Lopez, AF Parker, MW
2015 The beta c receptor family - Structural insights and their functional implications
Cytokine
Broughton, SE Nero, TL Dhagat, U Kan, WL Hercus, TR Tvorogov, D Lopez, AF Parker, MW
2016 Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling
Structure
Broughton, SE Hercus, TR Nero, TL Dottore, M McClure, BJ Dhagat, U Taing, H Gorman, MA King-Scott, J Lopez, AF Parker, MW
2016 CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common beta chain of the IL-3, GM-CSF and IL-5 receptors
Mabs
Panousis, C Dhagat, U Edwards, KM Rayzman, V Hardy, MP Braley, H Gauvreau, GM Hercus, TR Smith, S Sehmi, R McMillan, L Dottore, M McClure, BJ Fabri, LJ Vairo, G Lopez, AF Parker, MW Nash, AD Wilson, NJ Wilson, MJ Owczarek, CM
2018 Role of the beta Common (beta c) Family of Cytokines in Health and Disease
Cold Spring Harbor Perspect. Biol.
Hercus, TR Kan, WLT Broughton, SE Tvorogov, D Ramshaw, HS Sandow, JJ Nero, TL Dhagat, U Thompson, EJ Shing, KSCT McKenzie, DR Wilson, NJ Owczarek, CM Vairo, G Nash, AD Tergaonkar, V Hughes, T Ekert, PG Samuel, MS Bonder, CS Grimbaldeston, MA Parker, MW Lopez, AF
2018 A dual role for the N-terminal domain of the IL-3 receptor in cell signalling
Nat. Commun.
Broughton, SE Hercus, TR Nero, TL Kan, WL Barry, EF Dottore, M Shing, KSCT Morton, CJ Dhagat, U Hardy, MP Wilson, NJ Downton, MT Schieber, C Hughes, TP Lopez, AF Parker, MW
2018 The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities
Mabs
Dhagat, U Hercus, TR Broughton, SE Nero, TL Shing, KSCT Barry, EF Thomson, CA Bryson, S Pai, EF McClure, BJ Schrader, JW Lopez, AF Parker, MW
2018 Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis
Sci. Adv.
Tvorogov, D Thomas, D Liau, NPD Dottore, M Barry, EF Lathi, M Kan, WL Hercus, TR Stomski, F Hughes, TP Tergaonkar, V Parker, MW Ross, DM Majeti, R Babon, JJ Lopez, AF