Publications by Researcher: Holien, JK

Year	Title	Author(s)
2012	TRIM16 Acts as an E3 Ubiquitin Ligase and Can Heterodimerize with Other TRIM Family Members Plos One	Bell, JL Malyukova, A Holien, JK Koach, J Parker, MW Kavallaris, M Marshall, GM Cheung, BB
2012	Structure of the Lectin Regulatory Domain of the Cholesterol-Dependent Cytolysin Lectinolysin Reveals the Basis for Its Lewis Antigen Specificity Structure	Feil, SC Lawrence, S Mulhern, TD Holien, JK Hotze, EM Farrand, S Tweten, RK Parker, MW
2013	Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34 Cell Cycle	Suryadinata, R Holien, JK Yang, G Parker, MW Papaleo, E Sarcevic, B
2013	Lymphotoxin alpha induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor Febs Journal	Etemadi, N Holien, JK Chau, D Dewson, G Murphy, JM Alexander, WS Parker, MW Silke, J Nachbur, U
2013	Phosphorylation of Serine 779 in Fibroblast Growth Factor Receptor 1 and 2 by Protein Kinase C epsilon Regulates Ras/Mitogen-activated Protein Kinase Signaling and Neuronal Differentiation Journal Of Biological Chemistry	Lonic, A Powell, JA Kong, Y Thomas, D Holien, JK Truong, N Parker, MW Guthridge, MA
2013	Disarming Bacterial Virulence through Chemical Inhibition of the DNA Binding Domain of an AraC-like Transcriptional Activator Protein Journal Of Biological Chemistry	Yang, J Hocking, DM Cheng, C Dogovski, C Perugini, MA Holien, JK Parker, MW Hartland, EL Tauschek, M Robins-Browne, RM
2014	Oncogenic protein interfaces: small molecules, big challenges Nature Reviews Cancer	Nero, TL Morton, CJ Holien, JK Wielens, J Parker, MW
2014	Synthesis, Structure-Activity Relationships and Brain Uptake of a Novel Series of Benzopyran Inhibitors of Insulin-Regulated Aminopeptidase Journal Of Medicinal Chemistry	Mountford, SJ Albiston, AL Charman, WN Ng, L Holien, JK Parker, MW Nicolazzo, JA Thompson, PE Chai, SY
2014	A Systematic and Functional Classification of Streptococcus pyogenes That Serves as a New Tool for Molecular Typing and Vaccine Development Journal Of Infectious Diseases	Sanderson-Smith, M De Oliveira, DMP Guglielmini, J McMillan, DJ Vu, T Holien, JK Henningham, A Steer, AC Bessen, DE Dale, JB Curtis, N Beall, BW Walker, MJ Parker, MW Carapetis, JR Van Melderen, L Sriprakash, KS Smeesters, PR
2015	Computational analysis of amiloride analogue inhibitors of coxsackievirus B3 RNA polymerase J Proteomics Bioinform	Cameron, CE Jarrott, B Elliott, RW Gazina, EV Parker, MW Holien, JK Williams, SJ Petrou, S
2015	Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and efficiency J. Steroid Biochem. Mol. Biol.	Martin, LL Holien, JK Mizrachi, D Corbin, CJ Conley, AJ Parker, MW Rodgers, RJ
2015	Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1) Plos One	Simonov, AN Holien, JK Yeung, JC Nguyen, AD Corbin, CJ Zheng, J Kuznetsov, VL Auchus, RJ Conley, AJ Bond, AM Parker, MW Rodgers, RJ Martin, LL
2015	Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1) Plos One	Simonov, AN Holien, JK Yeung, JCI Nguyen, AD Corbin, CJ Zheng, J Kuznetsov, VL Auchus, RJ Conley, AJ Bond, AM Parker, MW Rodgers, RJ Martin, LL
2015	Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and effic Journal Of Steroid Biochemistry And Molecular Biology	Martin, LL Holien, JK Mizrachi, D Corbin, CJ Conley, AJ Parker, MW Rodgers, RJ
2015	Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding Biochemical Journal	Tomlinson, CG Moye, AL Holien, JK Parker, MW Cohen, SB Bryan, TM
2015	Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides Protein Science	Hermans, SJ Ascher, DB Hancock, NC Holien, JK Michell, BJ Chai, SY Morton, CJ Parker, MW
2015	A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production Nature Communications	Nachbur, U Stafford, CA Bankovacki, A Zhan, YF Lindqvist, LM Fiil, BK Khakham, Y Ko, HJ Sandow, JJ Falk, H Holien, JK Chau, D Hildebrand, J Vince, JE Sharp, PP Webb, AI Jackman, KA Muhlen, S Kennedy, CL Lowes, KN Murphy, JM Gyrd-Hansen, M Parker, MW Hartland, EL Lew, AM Huang, DCS Lessene, G Silke, J
2016	Mitochondrial fission - a drug target for cytoprotection or cytodestruction? Pharmacol. Res. Perspect.	Rosdah, AA Holien, JK Delbridge, LMD Dusting, GJ Lim, SY
2016	The C-terminal extension of human telomerase reverse transcriptase is necessary for high affinity binding to telomeric DNA Biochimie	Tomlinson, CG Holien, JK Mathias, JAT Parker, MW Bryan, TM
2017	Homodimer Model Can Resolve the Conundrum as to How Cytochrome P450 Oxidoreductase and Cytochrome b5 Compete for the Same Binding Site on Cytochrome P450c17 Curr. Protein Pept. Sci.	Holien, JK Parker, MW Conley, AJ Corbin, CJ Rodgers, RJ Martin, LL
2017	Control of Virulence Gene Expression by the Master Regulator, CfaD, in the Prototypical Enterotoxigenic Escherichia coli Strain, H10407 Front. Microbiol.	Hodson, C Yang, J Hocking, DM Azzopardi, K Chen, QY Holien, JK Parker, MW Tauschek, M Robins-Browne, RM
2018	AMP and adenosine are both ligands for adenosine 2B receptor signaling Bioorg. Med. Chem. Lett.	Holien, JK Seibt, B Roberts, V Salvaris, E Parker, MW Cowan, PJ Dwyer, KM
2019	Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface Cancer Research	Koach, J Holien, JK Massudi, H Carter, DR Ciampa, OC Herath, M Lim, T Seneviratne, JA Milazzo, G Murray, JE McCarroll, JA Liu, B Mayoh, C Keenan, B Stevenson, BW Gorman, MA Bell, JL Doughty, L Huttelmaier, S Oberthuer, A Fischer, M Gifford, AJ Liu, T Zhang, XL Zhu, SZ Gustafson, WC Haber, M Norris, MD Fletcher, JI Perini, G Parker, MW Cheung, BB Marshall, GM
2019	A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4 Scientific Reports	Gilson, PR Kumarasingha, R Thompson, J Zhang, XX Sietsma Penington, J Kalhor, R Bullen, HE Lehane, AM Dans, MG de Koning-Ward, TF Holien, JK Soares da Costa, TP Hulett, MD Buskes, MJ Crabb, BS Kirk, K Papenfuss, AT Cowman, AF Abbott, BM
2020	Sequence comparisons of cytochrome P450 aromatases from Australian animals predict differences in enzymatic activity and/or efficiency Biology Of Reproduction	Fatima, A Holien, JK Tiwari, C Parker, MW Rodgers, RJ Martin, LL
2020	Identification of RNA-Binding Proteins as Targetable Putative Oncogenes in Neuroblastoma International Journal Of Molecular Sciences	Bell, JL Hagemann, S Holien, JK Liu, T Nagy, Z Schulte, JH Misiak, D Huttelmaier, S
2020	A structural view of PA2G4 isoforms with opposing functions in cancer Journal Of Biological Chemistry	Stevenson, BW Gorman, MA Koach, J Cheung, BB Marshall, GM Parker, MW Holien, JK
2020	New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology Pharmacology & Therapeutics	Rosdah, AA Smiles, WJ Oakhill, JS Scott, JW Langendorf, CG Delbridge, LMD Holien, JK Lim, SY
2021	A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma Oncogene	Cheung, BB Kleynhans, A Mittra, R Kim, PY Holien, JK Nagy, Z Ciampa, OC Seneviratne, JA Mayoh, C Raipuria, M Gadde, S Massudi, H Wong, IPL Tan, O Gong, A Suryano, A Diakiw, SM Liu, B Arndt, GM Liu, T Kumar, N Sangfelt, O Zhu, SZ Norris, MD Haber, M Carter, DR Parker, MW Marshall, GM
2021	Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster Insect Biochemistry And Molecular Biology	Perry, T Chen, W Ghazali, R Yang, YT Christesen, D Martelli, F Lumb, C Luong, HNB Mitchell, J Holien, JK Parker, MW Sparks, TC Batterham, P
2022	Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission Cardiovascular Research	Kalkhoran, SB Kriston-Vizi, J Hernandez-Resendiz, S Crespo-Avilan, GE Rosdah, AA Lees, JG Da Costa, JRS Ling, NXY Holien, JK Samangouei, P Chinda, K Yap, EP Riquelme, JA Ketteler, R Yellon, DM Lim, SY Hausenloy, DJ
2022	Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability Proceedings Of The National Academy Of Sciences Of The United States Of America	Hodson, C Low, JKK van Twest, S Jones, SE Swuec, P Murphy, V Tsukada, K Fawkes, M Bythell-Douglas, R Davies, A Holien, JK O’Rourke, JJ Parker, BL Glaser, A Parker, MW Mackay, JP Blackford, AN Costa, A Deans, AJ