Publications by Researcher: Deans, AJ

2012 Fanconi proteins get histones moving
Embo Journal
Deans, AJ
2012 The DNA translocase activity of FANCM protects stalled replication forks
Hum Mol Genet
Schwab, RA Blackford, AN Nieminuszczy, J Deans, AJ West, SC Niedzwiedz, W
2013 Architecture and DNA Recognition Elements of the Fanconi Anemia FANCM-FAAP24 Complex
Coulthard, R Deans, AJ Swuec, P Bowles, M Costa, A West, SC McDonald, NQ
2013 Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1
Cell Cycle
Caldon, CE Sergio, CM Burgess, A Deans, AJ Sutherland, RL Musgrove, EA
2014 The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis
Journal Of Clinical Investigation
Smeets, MF DeLuca, E Wall, M Quach, JM Chalk, AM Deans, AJ Heierhorst, J Purton, LE Izon, DJ Walkley, CR
2014 The Architecture and Evolution of Cancer Neochromosomes
Cancer Cell
Garsed, DW Marshall, OJ Corbin, VDA Hsu, A Di Stefano, L Schroder, J Li, J Feng, ZP Kim, BW Kowarsky, M Lansdell, B Brookwell, R Myklebost, O Meza-Zepeda, L Holloway, AJ Pedeutour, F Choo, KHA Damore, MA Deans, AJ Papenfuss, AT Thomas, DM
2015 The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription
Mol. Cell
Schwab, RA Nieminuszczy, J Shah, F Langton, J Martinez, DL Liang, CC Cohn, MA Gibbons, RJ Deans, AJ Niedzwiedz, W
O’Rourke, JJ Deans, AJ
2016 The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair
Sci Rep
Vuono, EA Mukherjee, A Vierra, DA Adroved, MM Hodson, C Deans, AJ Howlett, NG
2017 A defined role for multiple Fanconi anemia gene products in DNA-damage-associated ubiquitination
Exp. Hematol.
Tan, WN Deans, AJ
2017 ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress
Dna Repair
Liu, R King, A Hoch, NC Chang, C Kelly, GL Deans, AJ Heierhorst, J
2017 The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2
Cell Reports
Swuec, P Renault, L Borg, A Shah, F Murphy, VJ van Twest, S Snijders, AP Deans, AJ Costa, A
2017 Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway
Mol. Cell
van Twest, S Murphy, VJ Hodson, C Tan, WN Swuec, P O’Rourke, JJ Heierhorst, J Crismani, W Deans, AJ
2017 Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway
Mollah, ZUA Quah, HS Graham, KL Jhala, G Krishnamurthy, B Dharma, JFM Chee, J Trivedi, PM Pappas, EG Mackin, L Chu, EPF Akazawa, S Fynch, S Hodson, C Deans, AJ Trapani, JA Chong, MMW Bird, PI Brodnicki, TC Thomas, HE Kay, TWH
2018 Phosphorylation of Drosophila Brahma on CDK-phosphorylation sites is important for cell cycle regulation and differentiation
Cell Cycle
Roesley, SNA La Marca, JE Deans, AJ Mckenzie, L Suryadinata, R Burke, P Portela, M Wang, HY Bernard, O Sarcevic, B Richardson, HE
2019 ALT control, delete: FANCM as an anti-cancer target in Alternative Lengthening of Telomeres
O’Rourke, JJ Bythell-Douglas, R Dunn, EA Deans, AJ
2019 ATP-dependent helicase activity is dispensable for the physiological functions of Recql4
Plos Genetics
Castillo-Tandazo, W Smeets, MF Murphy, V Liu, R Hodson, C Heierhorst, J Deans, AJ Walkley, CR
2019 FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops
Nature Communications
Silva, B Pentz, R Figueira, AM Arora, R Lee, YW Hodson, C Wischnewski, H Deans, AJ Azzalin, CM
2019 The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)
Nature Communications
Lu, R O’Rourke, JJ Sobinoff, AP Allen, JAM Nelson, CB Tomlinson, CG Lee, M Reddel, RR Deans, AJ Pickett, HA
2020 Formaldehyde Causes Bone Marrow Failure Linked to Transcriptional Reprogramming or Metabolic Deficiency
Molecular Cell
Tan, W Deans, AJ
2020 Structural insight into FANCI-FANCD2 monoubiquitination
Guardians Of The Genome: Dna Damage And Repair
Li, LD Tan, WN Deans, AJ
2020 ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2
Frontiers In Cell And Developmental Biology
Tan, WN van Twest, S Murphy, VJ Deans, AJ
2020 Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex
Scientific Reports
Sharp, MF Murphy, VJ Tan, W Lui, J Simpson, KJ Deans, AJ Crismani, W
2020 Monoubiquitination by the human Fanconi anemia core complex clamps FANCI: FANCD2 on DNA in filamentous arrays
Tan, W van Twest, S Leis, A Bythell-Douglas, R Murphy, VJ Sharp, M Parker, MW Crismani, W Deans, AJ
2020 Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin
Plos One
Tan, WN Murphy, VJ Charron, A van Twest, S Sharp, M Constantinou, A Parker, MW Crismani, W Bythell-Douglas, R Deans, AJ
2020 Association of clinical severity with FANCB variant type in Fanconi anemia
Jung, MJ Ramanagoudr-Bhojappa, R van Twest, S Rosti, RO Murphy, V Tan, W Donovan, FX Lach, FP Kimble, DC Jiang, CS Vaughan, R Mehta, PA Pierri, F Dufour, C Auerbach, AD Deans, AJ Smogorzewska, A Chandrasekharappa, SC
2020 CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer
Nature Communications
Sanij, E Hannan, KM Xuan, JC Yan, SF Ahern, JE Trigos, AS Brajanovski, N Son, J Chan, KT Kondrashova, O Lieschke, E Wakefield, MJ Frank, D Ellis, S Cullinane, C Kang, J Poortinga, G Nag, P Deans, AJ Khanna, KK Mileshkin, L McArthur, GA Soong, J Berns, EMJJ Hannan, RD Scott, CL Sheppard, KE Pearson, RB
2021 Fanconi anemia, put to sleep
Deans, AJ
2021 A Structural Guide to the Bloom Syndrome Complex
Bythell-Douglas, R Deans, AJ
2021 The ubiquitination machinery of the Fanconi Anemia DNA repair pathway
Progress In Biophysics & Molecular Biology
Tan, W Deans, AJ
2021 The Fanconi anemia ubiquitin E3 ligase complex as an anti-cancer target
Molecular Cell
Sharp, MF Bythell-Douglas, R Deans, AJ Crismani, W
2021 Protein truncating variants in FANCM and risk for ER-negative/triple negative breast cancer COMMENT
Npj Breast Cancer
Peterlongo, P Figlioli, G Deans, AJ Couch, FJ
2021 Cyclin-Dependent Kinase-Mediated Phosphorylation of FANCD2 Promotes Mitotic Fidelity
Molecular And Cellular Biology
Cantres-Velez, JA Blaize, JL Vierra, DA Boisvert, RA Garzon, JL Piraino, B Tan, WN Deans, AJ Howlett, NG
2021 Childhood acute myeloid leukemia shows a high level of germline predisposition
Samaraweera, SE Wang, PPS Li, KL Casolari, DA Feng, JH Pinese, M Maung, KZY Leo, P Cowley, M Perkins, K Smith, AM Ellis, J Wee, A Hiwase, DK Scott, HS Schreiber, AW Brown, AL Deans, AJ Ross, DM Moore, AS Gonda, TJ Hahn, CN Andrea, RJ
2022 Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability
Proceedings Of The National Academy Of Sciences Of The United States Of America
Hodson, C Low, JKK van Twest, S Jones, SE Swuec, P Murphy, V Tsukada, K Fawkes, M Bythell-Douglas, R Davies, A Holien, JK O’Rourke, JJ Parker, BL Glaser, A Parker, MW Mackay, JP Blackford, AN Costa, A Deans, AJ