Publications by Researcher: Kay, TWH

YearTitleAuthor(s)
2012 Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
Journal Of Experimental Medicine
Coppieters, KT Dotta, F Amirian, N Campbell, PD Kay, TWH Atkinson, MA Roep, BO von Herrath, MG
2012 Normalized NEFA Dynamics During an OGTT After Islet Transplantation
Transplantation
Vethakkan, SR Walters, JM Gooley, JL Boston, RC Kay, TWH Goodman, DJ Jenkins, AJ Ward, GM
2012 Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression
European Journal Of Immunology
Graham, KL Krishnamurthy, B Fynch, S Ayala-Perez, R Slattery, RM Santamaria, P Thomas, HE Kay, TWH
2012 Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors
International Immunology
Joffe, M Necula, AS Chand, R McWhinney, BC Krishnamurthy, B Loudovaris, T Goodman, D Thomas, HE Kay, TWH Mannering, SI
2012 Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells
Diabetes
Krishnamurthy, B Chee, J Jhala, G Fynch, S Graham, KL Santamaria, P Morahan, G Allison, J Izon, D Thomas, HE Kay, TWH
2012 Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010
Diabetes Care
Barton, FB Rickels, MR Alejandro, R Hering, BJ Wease, S Naziruddin, B Oberholzer, J Odorico, JS Garfinkel, MR Levy, M Pattou, F Berney, T Secchi, A Messinger, S Senior, PA Maffi, P Posselt, A Stock, PG Kaufman, DB Luo, XR Kandeel, F Cagliero, E Turgeon, NA Witkowski, P Naji, A O’Connell, PJ Greenbaum, C Kudva, YC Brayman, KL Aull, MJ Larsen, C Kay, TWH Fernandez, LA Vantyghem, MC Bellin, M Shapiro, AMJ
2014 The Incretin Response After Successful Islet Transplantation
Transplantation
Vethakkan, SR Walters, JM Gooley, JL Boston, RC Kay, TWH Goodman, DJ Jenkins, AJ Ward, GM
2014 Functional cytotoxic T lymphocytes against IGRP(206-214) predict diabetes in the non-obese diabetic mouse
Immunology And Cell Biology
Ko, HJ Chee, J Sutherland, RM Thomas, HE Zhan, YF Krishnamurthy, B Kay, TWH Lew, AM
2014 Deficiency in Type I Interferon Signaling Prevents the Early Interferon-Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice
Diabetes
Quah, HS Miranda-Hernandez, S Khoo, A Harding, A Fynch, S Elkerbout, L Brodnicki, TC Baxter, AG Kay, TWH Thomas, HE Graham, KL
2014 The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity
Cell Death & Disease
Wali, JA Rondas, D McKenzie, MD Zhao, Y Elkerbout, L Fynch, S Gurzov, EN Akira, S Mathieu, C Kay, TWH Overbergh, L Strasser, A Thomas, HE
2014 Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes
Journal Of Immunology
Chee, J Ko, HJ Skowera, A Jhala, G Catterall, T Graham, KL Sutherland, RM Thomas, HE Lew, AM Peakman, M Kay, TWH Krishnamurthy, B
2015 Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets
Diabetes
Stanley, WJ Litwak, SA Quah, HS Tan, SM Kay, TWH Tiganis, T de Haan, JB Thomas, HE Gurzov, EN
2015 Lipotoxic Stress Induces Pancreatic beta-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System
Journal Of Diabetes Research
Litwak, SA Wali, JA Pappas, EG Saadi, H Stanley, WJ Varanasi, LC Kay, TWH Thomas, HE Gurzov, EN
2015 Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate
Eur. J. Immunol.
Zhao, YX Scott, NA Quah, HS Krishnamurthy, B Bond, F Loudovaris, T Mannering, SI Kay, TWH Thomas, HE
2015 A comparative analysis of high-throughput platforms for validation of a circulating microRNA signature in diabetic retinopathy
Sci Rep
Farr, RJ Januszewski, AS Joglekar, MV Liang, H McAulley, AK Hewitt, AW Thomas, HE Loudovaris, T Kay, TWH Jenkins, A Hardikar, AA
2015 Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes
Diabetologia
Zhao, YX Scott, NA Fynch, S Elkerbout, L Wong, WWL Mason, KD Strasser, A Huang, DC Kay, TWH Thomas, HE
2015 Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer-Restricted CD4(+) T Cells Infiltrate Islets in Type 1 Diabetes
Diabetes
Pathiraja, V Kuehlich, JP Campbell, PD Krishnamurthy, B Loudovaris, T Coates, PTH Brodnicki, TC O’Connell, PJ Kedzierska, K Rodda, C Bergman, P Hill, E Purcell, AW Dudek, NL Thomas, HE Kay, TWH Mannering, SI
2015 BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells
Diabetes
Krishnamurthy, B Chee, J Jhala, G Trivedi, P Catterall, T Selck, C Gurzov, EN Brodnicki, TC Graham, KL Wali, JA Zhan, YF Gray, D Strasser, A Allison, J Thomas, HE Kay, TWH
2016 Long-term effects of islet transplantation
Curr. Opin. Organ Transpl.
Holmes-Walker, DJ Kay, TWH
2016 The case for an autoimmune aetiology of type 1 diabetes
Clin. Exp. Immunol.
Mannering, SI Pathiraja, V Kay, TWH
2016 Regenerative Medicine: Clinical Islet Transplantation
Stem Cell Biol. Regen. Med.
Thomas, HE Graham, KL Loudovaris, T Kay, TWH
2016 Analysis of antigen specific T cells in diabetes - Lessons from pre-clinical studies and early clinical trials
J. Autoimmun.
Krishnamurthy, B Selck, C Chee, J Jhala, G Kay, TWH
2016 Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling
Sci Rep
Pane, JA Fleming, FE Graham, KL Thomas, HE Kay, TWH Coulson, BS
2016 Coxsackievirus B5 Infection Induces Dysregulation of microRNAs Predicted to Target Known Type 1 Diabetes Risk Genes in Human Pancreatic Islets
Diabetes
Kim, KW Ho, A Alshabee-Akil, A Hardikar, AA Kay, TWH Rawlinson, WD Craig, ME
2016 Report from IPITA-TTS Opinion Leaders Meeting on the Future of beta-Cell Replacement
Transplantation
Bartlett, ST Markmann, JF Johnson, P Korsgren, O Hering, BJ Scharp, D Kay, TWH Bromberg, J Odorico, JS Weir, GC Bridges, N Kandaswamy, R Stock, P Friend, P Gotoh, M Cooper, DKC Park, CG O’Connell, P Stabler, C Matsumoto, S Ludwig, B Choudhary, P Kovatchev, B Rickels, MR Sykes, M Wood, K Kraemer, K Hwa, A Stanley, E Ricordi, C Zimmerman, M Greenstein, J Montanya, E Otonkoski, T
2016 Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of beta-Cell Replacement
Transplantation
Markmann, JF Bartlett, ST Johnson, P Korsgren, O Hering, BJ Scharp, D Kay, TWH Bromberg, J Odorico, JS Weir, GC Bridges, N Kandaswamy, R Stock, P Friend, P Gotoh, M Cooper, DKC Park, CG O’Connell, PJ Stabler, C Matsumoto, S Ludwig, B Choudhary, P Khovatchev, B Rickels, MR Sykes, M Wood, K Kraemer, K Hwa, A Stanley, E Ricordi, C Zimmerman, M Greenstein, J Montanya, E Otonkoski, T
2016 Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes
Jci Insight
Jhala, G Chee, J Trivedi, PM Selck, C Gurzov, EN Graham, KL Thomas, HE Kay, TWH Krishnamurthy, B
2017 First Report of Successful Total Pancreatectomy and Islet Autotransplant in Australia
Pancreas
Geyer, MC Coates, PT Khurana, S Chen, JWC Kay, TWH Balamurugan, AN Couper, JJ Radford, T Drogemuller, CJ Loudovaris, T Pathi, R Wilks, MJ Couper, RTL
2017 Understanding and preventing type 1 diabetes through the unique working model of TrialNet
Diabetologia
Battaglia, M Anderson, MS Buckner, JH Geyer, SM Gottlieb, PA Kay, TWH Lernmark, A Muller, S Pugliese, A Roep, BO Greenbaum, CJ Peakman, M
2017 Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility
Mol. Immunol.
Chu, EPF Elso, CM Pollock, AH Alsayb, MA Mackin, L Thomas, HE Kay, TWH Silveira, PA Mansell, AS Gaus, K Brodnicki, TC
2017 Islet Transplantation Provides Superior Glycemic Control With Less Hypoglycemia Compared With Continuous Subcutaneous Insulin Infusion or Multiple Daily Insulin Injections
Transplantation
Holmes-Walker, DJ Gunton, JE Hawthorne, W Payk, M Anderson, P Donath, S Loudovaris, T Ward, GM Kay, TWH O’Connell, PJ
2017 Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway
Diabetes
Mollah, ZUA Quah, HS Graham, KL Jhala, G Krishnamurthy, B Dharma, JFM Chee, J Trivedi, PM Pappas, EG Mackin, L Chu, EPF Akazawa, S Fynch, S Hodson, C Deans, AJ Trapani, JA Chong, MMW Bird, PI Brodnicki, TC Thomas, HE Kay, TWH
2018 Shuffling peptides to create T-cell epitopes: does the immune system play cards?
Immunol. Cell Biol.
Mannering, SI So, M Elso, CM Kay, TWH
2018 IFN gamma-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4(+) T Cell Migration
Front. Immunol.
Scott, NA Zhao, YX Krishnamurthy, B Mannering, SI Kay, TWH Thomas, HE
2018 NF-kappa B is weakly activated in the NOD mouse model of type 1 diabetes
Sci Rep
Irvin, AE Jhala, G Zhao, YX Blackwell, TS Krishnamurthy, B Thomas, HE Kay, TWH
2018 Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans
Plos One
Simeonovic, CJ Popp, SK Starrs, LM Brown, DJ Ziolkowski, AF Ludwig, B Bornstein, SR Wilson, JD Pugliese, A Kay, TWH Thomas, HE Loudovaris, T Choong, FJ Freeman, C Parish, CR
2018 Defining Outcomes for -cell Replacement Therapy in the Treatment of Diabetes: A Consensus Report on the Igls Criteria From the IPITA/EPITA Opinion Leaders Workshop
Transplantation
Rickels, MR Stock, PG de Koning, EJP Piemonti, L Pratschke, J Alejandro, R Bellin, MD Berney, T Choudhary, P Johnson, PR Kandaswamy, R Kay, TWH Keymeulen, B Kudva, YC Latres, E Langer, RM Lehmann, R Ludwig, B Markmann, JF Marinac, M Odorico, JS Pattou, F Senior, PA Shaw, JAM Vantyghem, MC White, S
2018 Oxygen-permeable microwell device maintains islet mass and integrity during shipping
Endocr. Connect.
Rojas-Canales, DM Waibel, M Forget, A Penko, D Nitschke, J Harding, FJ Delalat, B Blencowe, A Loudovaris, T Grey, ST Thomas, HE Kay, TWH Drogemuller, CJ Voelcker, NH Coates, PT
2018 Proinsulin C-peptide is an autoantigen in people with type 1 diabetes
Proc. Natl. Acad. Sci. U. S. A.
So, M Elso, CM Tresoldi, E Pakusch, M Pathiraja, V Wentworth, JM Harrison, LC Krishnamurthy, B Thomas, HE Rodda, C Cameron, FJ McMahon, J Kay, TWH Mannering, SI
2018 Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice
Cell Death Differ.
Wali, JA Galic, S Tan, CYR Gurzov, EN Frazier, AE Connor, T Ge, JJ Pappas, EG Stroud, D Varanasi, LC Selck, C Ryan, MT Thorburn, DR Kemp, BE Krishnamurthy, B Kay, TWH Thomas, HE