Publications by Researcher: Kay, TWH

Year	Title	Author(s)
2012	Normalized NEFA Dynamics During an OGTT After Islet Transplantation Transplantation	Vethakkan, SR Walters, JM Gooley, JL Boston, RC Kay, TWH Goodman, DJ Jenkins, AJ Ward, GM
2012	Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients Journal Of Experimental Medicine	Coppieters, KT Dotta, F Amirian, N Campbell, PD Kay, TWH Atkinson, MA Roep, BO von Herrath, MG
2012	Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression European Journal Of Immunology	Graham, KL Krishnamurthy, B Fynch, S Ayala-Perez, R Slattery, RM Santamaria, P Thomas, HE Kay, TWH
2012	Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors International Immunology	Joffe, M Necula, AS Chand, R McWhinney, BC Krishnamurthy, B Loudovaris, T Goodman, D Thomas, HE Kay, TWH Mannering, SI
2012	Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells Diabetes	Krishnamurthy, B Chee, J Jhala, G Fynch, S Graham, KL Santamaria, P Morahan, G Allison, J Izon, D Thomas, HE Kay, TWH
2012	Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010 Diabetes Care	Barton, FB Rickels, MR Alejandro, R Hering, BJ Wease, S Naziruddin, B Oberholzer, J Odorico, JS Garfinkel, MR Levy, M Pattou, F Berney, T Secchi, A Messinger, S Senior, PA Maffi, P Posselt, A Stock, PG Kaufman, DB Luo, XR Kandeel, F Cagliero, E Turgeon, NA Witkowski, P Naji, A O’Connell, PJ Greenbaum, C Kudva, YC Brayman, KL Aull, MJ Larsen, C Kay, TWH Fernandez, LA Vantyghem, MC Bellin, M Shapiro, AMJ
2014	The Incretin Response After Successful Islet Transplantation Transplantation	Vethakkan, SR Walters, JM Gooley, JL Boston, RC Kay, TWH Goodman, DJ Jenkins, AJ Ward, GM
2014	Functional cytotoxic T lymphocytes against IGRP(206-214) predict diabetes in the non-obese diabetic mouse Immunology And Cell Biology	Ko, HJ Chee, J Sutherland, RM Thomas, HE Zhan, YF Krishnamurthy, B Kay, TWH Lew, AM
2014	Deficiency in Type I Interferon Signaling Prevents the Early Interferon-Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice Diabetes	Quah, HS Miranda-Hernandez, S Khoo, A Harding, A Fynch, S Elkerbout, L Brodnicki, TC Baxter, AG Kay, TWH Thomas, HE Graham, KL
2014	The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity Cell Death & Disease	Wali, JA Rondas, D McKenzie, MD Zhao, Y Elkerbout, L Fynch, S Gurzov, EN Akira, S Mathieu, C Kay, TWH Overbergh, L Strasser, A Thomas, HE
2014	Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes Journal Of Immunology	Chee, J Ko, HJ Skowera, A Jhala, G Catterall, T Graham, KL Sutherland, RM Thomas, HE Lew, AM Peakman, M Kay, TWH Krishnamurthy, B
2015	Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets Diabetes	Stanley, WJ Litwak, SA Quah, HS Tan, SM Kay, TWH Tiganis, T de Haan, JB Thomas, HE Gurzov, EN
2015	Lipotoxic Stress Induces Pancreatic beta-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System Journal Of Diabetes Research	Litwak, SA Wali, JA Pappas, EG Saadi, H Stanley, WJ Varanasi, LC Kay, TWH Thomas, HE Gurzov, EN
2015	Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate Eur. J. Immunol.	Zhao, YX Scott, NA Quah, HS Krishnamurthy, B Bond, F Loudovaris, T Mannering, SI Kay, TWH Thomas, HE
2015	Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes Diabetologia	Zhao, YX Scott, NA Fynch, S Elkerbout, L Wong, WWL Mason, KD Strasser, A Huang, DC Kay, TWH Thomas, HE
2015	A comparative analysis of high-throughput platforms for validation of a circulating microRNA signature in diabetic retinopathy Sci Rep	Farr, RJ Januszewski, AS Joglekar, MV Liang, H McAulley, AK Hewitt, AW Thomas, HE Loudovaris, T Kay, TWH Jenkins, A Hardikar, AA
2015	Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer-Restricted CD4(+) T Cells Infiltrate Islets in Type 1 Diabetes Diabetes	Pathiraja, V Kuehlich, JP Campbell, PD Krishnamurthy, B Loudovaris, T Coates, PTH Brodnicki, TC O’Connell, PJ Kedzierska, K Rodda, C Bergman, P Hill, E Purcell, AW Dudek, NL Thomas, HE Kay, TWH Mannering, SI
2015	BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells Diabetes	Krishnamurthy, B Chee, J Jhala, G Trivedi, P Catterall, T Selck, C Gurzov, EN Brodnicki, TC Graham, KL Wali, JA Zhan, YF Gray, D Strasser, A Allison, J Thomas, HE Kay, TWH
2016	Long-term effects of islet transplantation Curr. Opin. Organ Transpl.	Holmes-Walker, DJ Kay, TWH
2016	The case for an autoimmune aetiology of type 1 diabetes Clin. Exp. Immunol.	Mannering, SI Pathiraja, V Kay, TWH
2016	Regenerative Medicine: Clinical Islet Transplantation Stem Cell Biol. Regen. Med.	Thomas, HE Graham, KL Loudovaris, T Kay, TWH
2016	Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling Sci Rep	Pane, JA Fleming, FE Graham, KL Thomas, HE Kay, TWH Coulson, BS
2016	Coxsackievirus B5 Infection Induces Dysregulation of microRNAs Predicted to Target Known Type 1 Diabetes Risk Genes in Human Pancreatic Islets Diabetes	Kim, KW Ho, A Alshabee-Akil, A Hardikar, AA Kay, TWH Rawlinson, WD Craig, ME
2016	Analysis of antigen specific T cells in diabetes - Lessons from pre-clinical studies and early clinical trials J. Autoimmun.	Krishnamurthy, B Selck, C Chee, J Jhala, G Kay, TWH
2016	Report from IPITA-TTS Opinion Leaders Meeting on the Future of beta-Cell Replacement Transplantation	Bartlett, ST Markmann, JF Johnson, P Korsgren, O Hering, BJ Scharp, D Kay, TWH Bromberg, J Odorico, JS Weir, GC Bridges, N Kandaswamy, R Stock, P Friend, P Gotoh, M Cooper, DKC Park, CG O’Connell, P Stabler, C Matsumoto, S Ludwig, B Choudhary, P Kovatchev, B Rickels, MR Sykes, M Wood, K Kraemer, K Hwa, A Stanley, E Ricordi, C Zimmerman, M Greenstein, J Montanya, E Otonkoski, T
2016	Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of beta-Cell Replacement Transplantation	Markmann, JF Bartlett, ST Johnson, P Korsgren, O Hering, BJ Scharp, D Kay, TWH Bromberg, J Odorico, JS Weir, GC Bridges, N Kandaswamy, R Stock, P Friend, P Gotoh, M Cooper, DKC Park, CG O’Connell, PJ Stabler, C Matsumoto, S Ludwig, B Choudhary, P Khovatchev, B Rickels, MR Sykes, M Wood, K Kraemer, K Hwa, A Stanley, E Ricordi, C Zimmerman, M Greenstein, J Montanya, E Otonkoski, T
2016	Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes Jci Insight	Jhala, G Chee, J Trivedi, PM Selck, C Gurzov, EN Graham, KL Thomas, HE Kay, TWH Krishnamurthy, B
2017	First Report of Successful Total Pancreatectomy and Islet Autotransplant in Australia Pancreas	Geyer, MC Coates, PT Khurana, S Chen, JWC Kay, TWH Balamurugan, AN Couper, JJ Radford, T Drogemuller, CJ Loudovaris, T Pathi, R Wilks, MJ Couper, RTL
2017	Understanding and preventing type 1 diabetes through the unique working model of TrialNet Diabetologia	Battaglia, M Anderson, MS Buckner, JH Geyer, SM Gottlieb, PA Kay, TWH Lernmark, A Muller, S Pugliese, A Roep, BO Greenbaum, CJ Peakman, M
2017	Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility Mol. Immunol.	Chu, EPF Elso, CM Pollock, AH Alsayb, MA Mackin, L Thomas, HE Kay, TWH Silveira, PA Mansell, AS Gaus, K Brodnicki, TC
2017	Islet Transplantation Provides Superior Glycemic Control With Less Hypoglycemia Compared With Continuous Subcutaneous Insulin Infusion or Multiple Daily Insulin Injections Transplantation	Holmes-Walker, DJ Gunton, JE Hawthorne, W Payk, M Anderson, P Donath, S Loudovaris, T Ward, GM Kay, TWH O’Connell, PJ
2017	Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway Diabetes	Mollah, ZUA Quah, HS Graham, KL Jhala, G Krishnamurthy, B Dharma, JFM Chee, J Trivedi, PM Pappas, EG Mackin, L Chu, EPF Akazawa, S Fynch, S Hodson, C Deans, AJ Trapani, JA Chong, MMW Bird, PI Brodnicki, TC Thomas, HE Kay, TWH
2018	Shuffling peptides to create T-cell epitopes: does the immune system play cards? Immunol. Cell Biol.	Mannering, SI So, M Elso, CM Kay, TWH
2018	IFN gamma-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4(+) T Cell Migration Front. Immunol.	Scott, NA Zhao, YX Krishnamurthy, B Mannering, SI Kay, TWH Thomas, HE
2018	NF-kappa B is weakly activated in the NOD mouse model of type 1 diabetes Sci Rep	Irvin, AE Jhala, G Zhao, YX Blackwell, TS Krishnamurthy, B Thomas, HE Kay, TWH
2018	Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans Plos One	Simeonovic, CJ Popp, SK Starrs, LM Brown, DJ Ziolkowski, AF Ludwig, B Bornstein, SR Wilson, JD Pugliese, A Kay, TWH Thomas, HE Loudovaris, T Choong, FJ Freeman, C Parish, CR
2018	Defining Outcomes for -cell Replacement Therapy in the Treatment of Diabetes: A Consensus Report on the Igls Criteria From the IPITA/EPITA Opinion Leaders Workshop Transplantation	Rickels, MR Stock, PG de Koning, EJP Piemonti, L Pratschke, J Alejandro, R Bellin, MD Berney, T Choudhary, P Johnson, PR Kandaswamy, R Kay, TWH Keymeulen, B Kudva, YC Latres, E Langer, RM Lehmann, R Ludwig, B Markmann, JF Marinac, M Odorico, JS Pattou, F Senior, PA Shaw, JAM Vantyghem, MC White, S
2018	Oxygen-permeable microwell device maintains islet mass and integrity during shipping Endocr. Connect.	Rojas-Canales, DM Waibel, M Forget, A Penko, D Nitschke, J Harding, FJ Delalat, B Blencowe, A Loudovaris, T Grey, ST Thomas, HE Kay, TWH Drogemuller, CJ Voelcker, NH Coates, PT
2018	Proinsulin C-peptide is an autoantigen in people with type 1 diabetes Proc. Natl. Acad. Sci. U. S. A.	So, M Elso, CM Tresoldi, E Pakusch, M Pathiraja, V Wentworth, JM Harrison, LC Krishnamurthy, B Thomas, HE Rodda, C Cameron, FJ McMahon, J Kay, TWH Mannering, SI
2018	Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice Cell Death Differ.	Wali, JA Galic, S Tan, CYR Gurzov, EN Frazier, AE Connor, T Ge, JJ Pappas, EG Stroud, D Varanasi, LC Selck, C Ryan, MT Thorburn, DR Kemp, BE Krishnamurthy, B Kay, TWH Thomas, HE
2019	IL-21 regulates SOCS1 expression in autoreactive CD8(+) T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice Scientific Reports	Sutherland, APR Graham, KL Papadimitriou, M Jhala, G Trivedi, P Catterall, T Fynch, S Kay, TWH Thomas, HE
2019	Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice Cell Death Discovery	Trivedi, PM Fynch, S Kennedy, LM Chee, J Krishnamurthy, B O’Reilly, LA Strasser, A Kay, TWH Thomas, HE
2019	T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities Diabetes	Wiede, F Brodnicki, TC Goh, PK Leong, YA Jones, GW Yu, D Baxter, AG Jones, SA Kay, TWH Tiganis, T
2020	IL-17F induces inflammation, dysfunction and cell death in mouse islets Scientific Reports	Catterall, T Fynch, S Kay, TWH Thomas, HE Sutherland, APR
2021	Harnessing CD8(+) T-cell exhaustion to treat type 1 diabetes Immunology And Cell Biology	Kwong, CTJ Selck, C Tahija, K McAnaney, LJ Le, DV Kay, TWH Thomas, HE Krishnamurthy, B
2021	Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice Frontiers In Immunology	Jhala, G Selck, C Chee, J Kwong, CTJ Pappas, EG Thomas, HE Kay, TWH Krishnamurthy, B
2021	Severe acute respiratory syndrome coronavirus 2 as a potential cause of type 1 diabetes facilitated by spike protein receptor binding domain attachment to human islet cells: An illustrative case study and experimental data Diabetic Medicine	Venkatesh, N Astbury, N Thomas, MC Rosado, CJ Pappas, E Krishnamurthy, B MacIsaac, RJ Kay, TWH Thomas, HE O’Neal, DN
2021	Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice Diabetologia	Akazawa, S Mackin, L Jhala, G Fynch, S Catterall, T Selck, C Graham, KL Krishnamurthy, B Pappas, EG Kwong, CTJ Sutherland, APR Kay, TWH Brodnicki, TC Thomas, HE
2021	Development of a standardized MRI protocol for pancreas assessment in humans Plos One	Virostko, J Craddock, RC Williams, JM Triolo, TM Hilmes, MA Kang, H Du, LP Wright, JJ Kinney, M Maki, JH Medved, M Waibel, M Kay, TWH Thomas, HE Greeley, SAW Steck, AK Moore, DJ Powers, AC
2022	Case Report: Hypoglycemia Due to a Novel Activating Glucokinase Variant in an Adult - a Molecular Approach Frontiers In Endocrinology	Koneshamoorthy, A Seniveratne-Epa, D Calder, G Sawyer, M Kay, TWH Farrell, S Loudovaris, T Mariana, L McCarthy, D Lyu, RQ Liu, X Thorn, P Tong, JS Chin, LK Zacharin, M Trainer, A Taylor, S MacIsaac, RJ Sachithanandan, N Thomas, HE Krishnamurthy, B