Publications by Researcher: Kemp, BE

YearTitleAuthor(s)
2012 AMPK functions as an adenylate charge-regulated protein kinase
Trends In Endocrinology And Metabolism
Oakhill, JS Scott, JW Kemp, BE
2012 Pro-GRP-Derived Peptides Are Expressed in Colorectal Cancer Cells and Tumors and Are Biologically Active in Vivo
Endocrinology
Patel, O Clyde, D Chang, M Nordlund, MS Steel, R Kemp, BE Pritchard, DM Shulkes, A Baldwin, GS
2012 The Outcome of Renal Ischemia-Reperfusion Injury Is Unchanged in AMPK-beta 1 Deficient Mice
Plos One
Mount, PF Gleich, K Tam, S Fraser, SA Choy, SW Dwyer, KM Lu, B van Denderen, B Fingerle-Rowson, G Bucala, R Kemp, BE Power, DA
2012 The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase
Science
Hawley, SA Fullerton, MD Ross, FA Schertzer, JD Chevtzoff, C Walker, KJ Peggie, MW Zibrova, D Green, KA Mustard, KJ Kemp, BE Sakamoto, K Steinberg, GR Hardie, DG
2013 AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1
American Journal Of Physiology-renal Physiology
Fraser, SA Choy, SW Pastor-Soler, NM Li, H Davies, MRP Cook, N Katerelos, M Mount, PF Gleich, K McRae, JL Dwyer, KM van Denderen, B Hallows, KR Kemp, BE Power, DA
2013 Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
Nature Medicine
Fullerton, MD Galic, S Marcinko, K Sikkema, S Pulinilkunnil, T Chen, ZP O’Neill, HM Ford, RJ Palanivel, R O’Brien, M Hardie, DG Macaulay, SL Schertzer, JD Dyck, JRB van Denderen, B Kemp, BE Steinberg, GR
2014 Mutant TDP-43 Deregulates AMPK Activation by PP2A in ALS Models
Plos One
Perera, ND Sheean, RK Scott, JW Kemp, BE Horne, MK Turner, BJ
2014 Reduced skeletal muscle AMPK and mitochondrial markers do not promote age-induced insulin resistance
Journal Of Applied Physiology
Bujak, AL Blumer, RME Marcinko, K Fullerton, MD Kemp, BE Steinberg, GR
2014 ATP sensitive bi-quinoline activator of the AMP-activated protein kinase
Biochemical And Biophysical Research Communications
Scott, JW Oakhill, JS Ling, NXY Langendorf, CG Foitzik, RC Kemp, BE Issinger, OG
2014 Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662
American Journal Of Physiology-endocrinology And Metabolism
Ducommun, S Ford, RJ Bultot, L Deak, M Bertrand, L Kemp, BE Steinberg, GR Sakamoto, K
2014 Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK
American Journal Of Physiology-renal Physiology
Davies, M Fraser, SA Galic, S Choy, SW Katerelos, M Gleich, K Kemp, BE Mount, PF Power, DA
2014 Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress
Faseb Journal
McGee, SL Swinton, C Morrison, S Gaur, V Campbell, DE Jorgensen, SB Kemp, BE Baar, K Steinberg, GR Hargreaves, M
2014 PPAR delta activation attenuates hepatic steatosis in Ldlr(-/-) mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity
Journal Of Lipid Research
Bojic, LA Telford, DE Fullerton, MD Ford, RJ Sutherland, BG Edwards, JY Sawyez, CG Gros, R Kemp, BE Steinberg, GR Huff, MW
2014 Activation of AMPK reduces the co-transporter activity of NKCC1
Molecular Membrane Biology
Fraser, SA Davies, M Katerelos, M Gleich, K Choy, SW Steel, R Galic, S Mount, PF Kemp, BE Power, DA
2014 Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling
Chemistry & Biology
Scott, JW Ling, NM Issa, SMA Dite, TA O’Brien, MT Chen, ZP Galic, S Langendorf, CG Steinberg, GR Kemp, BE Oakhill, JS
2014 Muscle-specific AMPK beta 1 beta 2-null mice display a myopathy due to loss of capillary density in nonpostural muscles
Faseb Journal
Thomas, MM Wang, DC D’Souza, DM Krause, MP Layne, AS Criswell, DS O’Neill, HM Connor, MK Anderson, JE Kemp, BE Steinberg, GR Hawke, TJ
2014 AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
Diabetologia
O’Neill, HM Lally, JS Galic, S Thomas, M Azizi, PD Fullerton, MD Smith, BK Pulinilkunnil, T Chen, ZP Samaan, MC Jorgensen, SB Dyck, JRB Holloway, GP Hawke, TJ van Denderen, B Kemp, BE Steinberg, GR
2015 Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release
Chem Biol
Langendorf, CG Steinberg, GR Galic, S Issa, SMA Birnberg, NC Scott, JW Dite, TA Kay, TW Ling, NXY Thomas, HE Foitzik, R Weng, QP Kemp, BE Graham, KL Oakhill, JS
2015 Choreography of AMPK activation
Cell Research
Langendorf, CG Kemp, BE
2015 High intensity interval training improves liver and adipose tissue insulin sensitivity
Mol. Metab.
Marcinko, K Sikkema, SR Samaan, MC Kemp, BE Fullerton, MD Steinberg, GR
2015 Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis
Biochem. J.
O’Brien, AJ Villani, LA Broadfield, LA Houde, VP Galic, S Blandino, G Kemp, BE Tsakiridis, T Muti, P Steinberg, GR
2015 Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging
Aging Cell
Crane, JD MacNeil, LG Lally, JS Ford, RJ Bujak, AL Brar, IK Kemp, BE Raha, S Steinberg, GR Tarnopolsky, MA
2015 The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice
Mol. Metab.
Marcinko, K Bujak, AL Lally, JSV Ford, RJ Wong, TH Smith, BK Kemp, BE Jenkins, Y Li, W Kinsella, TM Hitoshi, Y Steinberg, GR
2015 AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging
Cell Metab.
Bujak, AL Crane, JD Lally, JS Ford, RJ Kang, SJ Rebalka, IA Green, AE Kemp, BE Hawke, TJ Schertzer, JD Steinberg, GR
2015 AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism
Cardiovasc. Res.
Sung, MM Zordoky, BN Bujak, AL Lally, JSV Fung, D Young, ME Horman, S Miller, EJ Light, PE Kemp, BE Steinberg, GR Dyck, JRB
2015 Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder
Sci Rep
Scott, JW Park, E Rodriguiz, RM Oakhill, JS Issa, SMA O’Brien, MT Dite, TA Langendorf, CG Wetsel, WC Means, AR Kemp, BE
2015 Salicylate improves macrophage cholesterol homeostasis via activation of Ampk
Journal Of Lipid Research
Fullerton, MD Ford, RJ McGregor, CP LeBlond, ND Snider, SA Stypa, SA Day, EA Lhotak, S Schertzer, JD Austin, RC Kemp, BE Steinberg, GR
2015 SnRK1 from Arabidopsis thaliana is an atypical AMPK
Plant Journal
Emanuelle, S Hossain, MI Moller, IE Pedersen, HL van de Meene, AML Doblin, MS Koay, A Oakhill, JS Scott, JW Willats, WGT Kemp, BE Bacic, A Gooley, PR Stapleton, DI
2015 Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity
Biochem. J.
Ford, RJ Fullerton, MD Pinkosky, SL Day, EA Scott, JW Oakhill, JS Bujak, AL Smith, BK Crane, JD Blumer, RM Marcinko, K Kemp, BE Gerstein, HC Steinberg, GR
2015 Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release
Chem. Biol.
Scott, JW Galic, S Graham, KL Foitzik, R Ling, NXY Dite, TA Issa, SMA Langendorf, CG Weng, QP Thomas, HE Kay, TW Birnberg, NC Steinberg, GR Kemp, BE Oakhill, JS
2016 Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons
Plos One
Bayliss, JA Lemus, MB Santos, VV Deo, M Davies, JS Kemp, BE Elsworth, JD Andrews, ZB
2016 Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 & 2 and AMP-activated Protein Kinase in the Kidney
Sci Rep
Christensen, M Jensen, JB Jakobsen, S Jessen, N Frokiaer, J Kemp, BE Marciszyn, AL Li, H Pastor-Soler, NM Hallows, KR Norregaard, R
2016 beta-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase
Sci Rep
Ali, N Ling, NM Krishnamurthy, S Oakhill, JS Scott, JW Stapleton, DI Kemp, BE Anand, GS Gooley, PR
2016 Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease
J. Neurosci.
Bayliss, JA Lemus, MB Stark, R Santos, VV Thompson, A Rees, DJ Galic, S Elsworth, JD Kemp, BE Davies, JS Andrews, ZB
2016 Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding
Nat. Commun.
Langendorf, CG Ngoei, KRW Scott, JW Ling, NXY Issa, SMA Gorman, MA Parker, MW Sakamoto, K Oakhill, JS Kemp, BE
2016 Immortalized Parkinson's disease lymphocytes have enhanced mitochondrial respiratory activity
Dis. Model. Mech.
Annesley, SJ Lay, ST De Piazza, SW Sanislav, O Hammersley, E Allan, CY Francione, LM Bui, MQ Chen, ZP Ngoei, KRW Tassone, F Kemp, BE Storey, E Evans, A Loesch, DZ Fisher, PR
2016 Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-beta 1
Diabetes
Smith, BK Ford, RJ Desjardins, EM Green, AE Hughes, MC Houde, VP Day, EA Marcinko, K Crane, JD Mottillo, EP Perry, CGR Kemp, BE Tarnopolsky, MA Steinberg, GR
2016 Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function
Cell Metab.
Mottillo, EP Desjardins, EM Crane, JD Smith, BK Green, AE Ducommun, S Henriksen, TI Rebalka, IA Razi, A Sakamoto, K Scheele, C Kemp, BE Hawke, TJ Ortega, J Granneman, JG Steinberg, GR
2016 An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice
Nat. Med.
Rohm, M Schafer, M Laurent, V Ustunel, BE Niopek, K Algire, C Hautzinger, O Sijmonsma, TP Zota, A Medrikova, D Pellegata, NS Ryden, M Kulyte, A Dahlman, I Arner, P Petrovic, N Cannon, B Amri, EZ Kemp, BE Steinberg, GR Janovska, P Kopecky, J Wolfrum, C Bluher, M Diaz, MB Herzig, S
2017 Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation
Sci Rep
O’Brien, MT Oakhill, JS Ling, NMXY Langendorf, CG Hoque, A Dite, TA Means, AR Kemp, BE Scott, JW
2017 AMPK beta 1 reduces tumor progression and improves survival in p53 null mice
Mol. Oncol.
Houde, VP Donzelli, S Sacconi, A Galic, S Hammill, JA Bramson, JL Foster, RA Tsakiridis, T Kemp, BE Grasso, G Blandino, G Muti, P Steinberg, GR
2017 The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
Nat. Commun.
Dite, TA Ling, NXY Scott, JW Hoque, A Galic, S Parker, BL Ngoei, KRW Langendorf, CG O’Brien, MT Kundu, M Viollet, B Steinberg, GR Sakamoto, K Kemp, BE Oakhill, JS
2018 Visualizing AMPK Drug Binding Sites Through Crystallization of Full-Length Phosphorylated alpha 2 beta 1 gamma 1 Heterotrimer
Methods Mol. Biol.
Langendorf, CG Oakhill, JS Kemp, BE
2018 Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin
J. Am. Soc. Nephrol.
Lee, M Katerelos, M Gleich, K Galic, S Kemp, BE Mount, PF Power, DA
2018 AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis
Elife
Galic, S Loh, K Murray-Segal, L Steinberg, GR Andrews, ZB Kemp, BE
2018 AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation
Blood
Lepropre, S Kautbally, S Octave, M Ginion, A Onselaer, MB Steinberg, GR Kemp, BE Hego, A Wera, O Brouns, S Swieringa, F Giera, M Darley-Usmar, VM Ambroise, J Guigas, B Heemskerk, J Bertrand, L Oury, C Beauloye, C Horman, S
2018 Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo
Nat. Med.
Madiraju, AK Qiu, Y Perry, RJ Rahimi, Y Zhang, XM Zhang, DY Camporez, JPG Cline, GW Butrico, GM Kemp, BE Casals, G Steinberg, GR Vatner, DF Petersen, KF Shulman, GI
2018 AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965
J. Biol. Chem.
Dite, TA Langendorf, CG Hoque, A Galic, S Rebello, RJ Ovens, AJ Lindqvist, LM Ngoei, KRW Ling, NXY Furic, L Kemp, BE Scott, JW Oakhill, JS
2018 The Spectrum of Neurological and White Matter Changes and Premutation Status Categories of Older Male Carriers of the FMR1 Alleles Are Linked to Genetic (CGG and FMR1 mRNA) and Cellular Stress (AMPK) Markers
Front. Genet.
Loesch, DZ Trost, N Bui, MQ Hammersley, E Lay, ST Annesley, SJ Sanislav, O Allan, CY Tassone, F Chen, ZP Ngoei, KRW Kemp, BE Francis, D Fisher, PR Storey, E
2018 Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells
Cell Death Discov.
Hogue, A Sivakumaran, P Bond, ST Ling, NXY Kong, AM Scott, JW Bandara, N Hernandez, D Liu, GS Wong, RCB Ryan, MT Hausenloy, DJ Kemp, BE Oakhill, JS Drew, BG Pebay, A Lim, SY
2018 Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice
Cell Death Differ.
Wali, JA Galic, S Tan, CYR Gurzov, EN Frazier, AE Connor, T Ge, JJ Pappas, EG Stroud, D Varanasi, LC Selck, C Ryan, MT Thorburn, DR Kemp, BE Krishnamurthy, B Kay, TWH Thomas, HE
2018 Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4
Cell Chem. Biol.
Ngoei, KRW Langendorf, CG Ling, NXY Hoque, A Varghese, S Camerino, MA Walker, SR Bozikis, YE Dite, TA Ovens, AJ Smiles, WJ Jacobs, R Huang, H Parker, MW Scott, JW Rider, MH Foitzik, RC Kemp, BE Baell, JB Oakhill, JS
2019 Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance
Hepatol. Commun.
Loh, K Tam, S Murray-Segal, L Huynh, K Meikle, PJ Scott, JW van Denderen, B Chen, ZP Steel, R LeBlond, ND Burkovsky, LA O’Dwyer, C Nunes, JRC Steinberg, GR Fullerton, MD Galic, S Kemp, BE