Publications by Researcher: Steinberg, GR

2012 Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance
Palanivel, R Fullerton, MD Galic, S Honeyman, J Hewitt, KA Jorgensen, SB Steinberg, GR
2012 The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase
Hawley, SA Fullerton, MD Ross, FA Schertzer, JD Chevtzoff, C Walker, KJ Peggie, MW Zibrova, D Green, KA Mustard, KJ Kemp, BE Sakamoto, K Steinberg, GR Hardie, DG
2013 AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity
Molecular And Cellular Endocrinology
O’Neill, HM Holloway, GP Steinberg, GR
2013 Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity
Jorgensen, SB O’Neill, HM Sylow, L Honeyman, J Hewitt, KA Palanivel, R Fullerton, MD Oberg, L Balendran, A Galic, S van der Poel, C Trounce, IA Lynch, GS Schertzer, JD Steinberg, GR
2013 Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
Nature Medicine
Fullerton, MD Galic, S Marcinko, K Sikkema, S Pulinilkunnil, T Chen, ZP O’Neill, HM Ford, RJ Palanivel, R O’Brien, M Hardie, DG Macaulay, SL Schertzer, JD Dyck, JRB van Denderen, B Kemp, BE Steinberg, GR
2014 Hepatic Glucose Intolerance Precedes Hepatic Steatosis in the Male Aromatase Knockout (ArKO) Mouse
Plos One
Van Sinderen, ML Steinberg, GR Jorgensen, SB To, SQ Knower, KC Clyne, CD Honeyman, J Chow, JD Herridge, KA Jones, MEE Simpson, ER Boon, WC
2014 Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity
Biochemical Journal
Galic, S Sachithanandan, N Kay, TW Steinberg, GR
2014 Reduced skeletal muscle AMPK and mitochondrial markers do not promote age-induced insulin resistance
Journal Of Applied Physiology
Bujak, AL Blumer, RME Marcinko, K Fullerton, MD Kemp, BE Steinberg, GR
2014 Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662
American Journal Of Physiology-endocrinology And Metabolism
Ducommun, S Ford, RJ Bultot, L Deak, M Bertrand, L Kemp, BE Steinberg, GR Sakamoto, K
2014 Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress
Faseb Journal
McGee, SL Swinton, C Morrison, S Gaur, V Campbell, DE Jorgensen, SB Kemp, BE Baar, K Steinberg, GR Hargreaves, M
2014 Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling
Chemistry & Biology
Scott, JW Ling, NM Issa, SMA Dite, TA O’Brien, MT Chen, ZP Galic, S Langendorf, CG Steinberg, GR Kemp, BE Oakhill, JS
2014 PPAR delta activation attenuates hepatic steatosis in Ldlr(-/-) mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity
Journal Of Lipid Research
Bojic, LA Telford, DE Fullerton, MD Ford, RJ Sutherland, BG Edwards, JY Sawyez, CG Gros, R Kemp, BE Steinberg, GR Huff, MW
2014 Muscle-specific AMPK beta 1 beta 2-null mice display a myopathy due to loss of capillary density in nonpostural muscles
Faseb Journal
Thomas, MM Wang, DC D’Souza, DM Krause, MP Layne, AS Criswell, DS O’Neill, HM Connor, MK Anderson, JE Kemp, BE Steinberg, GR Hawke, TJ
2014 AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
O’Neill, HM Lally, JS Galic, S Thomas, M Azizi, PD Fullerton, MD Smith, BK Pulinilkunnil, T Chen, ZP Samaan, MC Jorgensen, SB Dyck, JRB Holloway, GP Hawke, TJ van Denderen, B Kemp, BE Steinberg, GR
2015 Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release
Chem Biol
Kay, TW Ling, NXY Thomas, HE Foitzik, R Weng, QP Kemp, BE Graham, KL Langendorf, CG Steinberg, GR Galic, S Issa, SMA Birnberg, NC Scott, JW Dite, TA Oakhill, JS
2015 Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice
Plos One
Van Sinderen, ML Steinberg, GR Jorgensen, SB Honeyman, J Chow, JD Herridge, KA Winship, AL Dimitriadis, E Jones, MEE Simpson, ER Boon, WC
2015 High intensity interval training improves liver and adipose tissue insulin sensitivity
Mol. Metab.
Marcinko, K Sikkema, SR Samaan, MC Kemp, BE Fullerton, MD Steinberg, GR
2015 Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging
Aging Cell
Crane, JD MacNeil, LG Lally, JS Ford, RJ Bujak, AL Brar, IK Kemp, BE Raha, S Steinberg, GR Tarnopolsky, MA
2015 Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis
Biochem. J.
O’Brien, AJ Villani, LA Broadfield, LA Houde, VP Galic, S Blandino, G Kemp, BE Tsakiridis, T Muti, P Steinberg, GR
2015 AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism
Cardiovasc. Res.
Sung, MM Zordoky, BN Bujak, AL Lally, JSV Fung, D Young, ME Horman, S Miller, EJ Light, PE Kemp, BE Steinberg, GR Dyck, JRB
2015 AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging
Cell Metab.
Bujak, AL Crane, JD Lally, JS Ford, RJ Kang, SJ Rebalka, IA Green, AE Kemp, BE Hawke, TJ Schertzer, JD Steinberg, GR
2015 The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice
Mol. Metab.
Marcinko, K Bujak, AL Lally, JSV Ford, RJ Wong, TH Smith, BK Kemp, BE Jenkins, Y Li, W Kinsella, TM Hitoshi, Y Steinberg, GR
2015 Salicylate improves macrophage cholesterol homeostasis via activation of Ampk
Journal Of Lipid Research
Fullerton, MD Ford, RJ McGregor, CP LeBlond, ND Snider, SA Stypa, SA Day, EA Lhotak, S Schertzer, JD Austin, RC Kemp, BE Steinberg, GR
2015 Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release
Chem. Biol.
Scott, JW Galic, S Graham, KL Foitzik, R Ling, NXY Dite, TA Issa, SMA Langendorf, CG Weng, QP Thomas, HE Kay, TW Birnberg, NC Steinberg, GR Kemp, BE Oakhill, JS
2015 Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity
Biochem. J.
Ford, RJ Fullerton, MD Pinkosky, SL Day, EA Scott, JW Oakhill, JS Bujak, AL Smith, BK Crane, JD Blumer, RM Marcinko, K Kemp, BE Gerstein, HC Steinberg, GR
2016 Exercise reverses age-related vulnerability of the retina to injury by preventing complement-mediated synapse elimination via a BDNF-dependent pathway
Aging Cell
Chrysostomou, V Galic, S van Wijngaarden, P Trounce, IA Steinberg, GR Crowston, JG
2016 Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-beta 1
Smith, BK Ford, RJ Desjardins, EM Green, AE Hughes, MC Houde, VP Day, EA Marcinko, K Crane, JD Mottillo, EP Perry, CGR Kemp, BE Tarnopolsky, MA Steinberg, GR
2016 Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function
Cell Metab.
Mottillo, EP Desjardins, EM Crane, JD Smith, BK Green, AE Ducommun, S Henriksen, TI Rebalka, IA Razi, A Sakamoto, K Scheele, C Kemp, BE Hawke, TJ Ortega, J Granneman, JG Steinberg, GR
2016 An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice
Nat. Med.
Rohm, M Schafer, M Laurent, V Ustunel, BE Niopek, K Algire, C Hautzinger, O Sijmonsma, TP Zota, A Medrikova, D Pellegata, NS Ryden, M Kulyte, A Dahlman, I Arner, P Petrovic, N Cannon, B Amri, EZ Kemp, BE Steinberg, GR Janovska, P Kopecky, J Wolfrum, C Bluher, M Diaz, MB Herzig, S
2017 The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
Nat. Commun.
Dite, TA Ling, NXY Scott, JW Hoque, A Galic, S Parker, BL Ngoei, KRW Langendorf, CG O’Brien, MT Kundu, M Viollet, B Steinberg, GR Sakamoto, K Kemp, BE Oakhill, JS
2017 AMPK beta 1 reduces tumor progression and improves survival in p53 null mice
Mol. Oncol.
Houde, VP Donzelli, S Sacconi, A Galic, S Hammill, JA Bramson, JL Foster, RA Tsakiridis, T Kemp, BE Grasso, G Blandino, G Muti, P Steinberg, GR
2018 AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis
Galic, S Loh, K Murray-Segal, L Steinberg, GR Andrews, ZB Kemp, BE
2018 AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation
Lepropre, S Kautbally, S Octave, M Ginion, A Onselaer, MB Steinberg, GR Kemp, BE Hego, A Wera, O Brouns, S Swieringa, F Giera, M Darley-Usmar, VM Ambroise, J Guigas, B Heemskerk, J Bertrand, L Oury, C Beauloye, C Horman, S
2018 Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo
Nat. Med.
Madiraju, AK Qiu, Y Perry, RJ Rahimi, Y Zhang, XM Zhang, DY Camporez, JPG Cline, GW Butrico, GM Kemp, BE Casals, G Steinberg, GR Vatner, DF Petersen, KF Shulman, GI
2019 Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance
Hepatol. Commun.
Loh, K Tam, S Murray-Segal, L Huynh, K Meikle, PJ Scott, JW van Denderen, B Chen, ZP Steel, R LeBlond, ND Burkovsky, LA O’Dwyer, C Nunes, JRC Steinberg, GR Fullerton, MD Galic, S Kemp, BE
2020 Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue
Biochemical Journal
Hussain, N Chuang, SJ Johanns, M Vertommen, D Steinberg, GR Kemp, BE Rider, MH
2020 Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK beta 1 isoforms
Nature Metabolism
Pinkosky, SL Scott, JW Desjardins, EM Smith, BK Day, EA Ford, RJ Langendorf, CG Ling, NXY Nero, TL Loh, K Galic, S Hoque, A Smiles, WJ Ngoei, KRW Parker, MW Yan, Y Melcher, K Kemp, BE Oakhill, JS Steinberg, GR
2021 AMPK activation by SC4 inhibits noradrenaline- induced lipolysis and insulin-stimulated lipogenesis in white tissue
Biochemical Journal
Chuang, SJ Johanns, M Ruys, SPD Steinberg, GR Kemp, BE Viollet, B Rider, MH
2021 AMPK mediates energetic stress-induced liver GDF15
Faseb Journal
Townsend, LK Weber, AJ Day, EA Shamshoum, H Shaw, SJ Perry, CGR Kemp, BE Steinberg, GR Wright, DC
2021 Salsalate reduces atherosclerosis through AMPK beta 1 in mice
Molecular Metabolism
Day, EA Ford, RJ Smith, BK Ronde, VP Stypa, S Rehal, S Lhotak, S Kemp, BE Trigatti, BL Werstuck, GH Austin, RC Fullerton, MD Steinberg, GR
2021 Compound- and fiber type-selective requirement of AMPKy3 for insulin-independent glucose uptake in skeletal muscle
Molecular Metabolism
Rhein, P Desjardins, EM Rong, P Ahwazi, D Bonhoure, N Stolte, J Santos, MD Ovens, AJ Ehrlich, AM Garcia, JLS Ouyang, Q Yabut, JM Membrez, M Kjolby, M Jessen, N Oakhill, JS Treebak, JT Maire, P Scott, JW Sanders, MJ Descombes, P Chen, S Steinberg, GR Sakamoto, K
2022 Blocking AMPK?1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis
Cell Reports
Neopane, K Kozlov, N Negoita, F Murray-Segal, L Brink, R Hoque, A Ovens, AJ Tjin, G McAloon, LM Yu, DY Ling, NXY Sanders, MJ Oakhill, JS Scott, JW Steinberg, GR Loh, K Kemp, BE Sakamoto, K Galic, S
2022 Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia
Cell Metabolism
Morrow, MR Batchuluun, B Wu, JH Ahmadi, E Leroux, JM Mohammadi-Shemirani, P Desjardins, EM Wang, ZC Tsakiridis, EE Lavoie, DCT Reihani, A Smith, BK Kwiecien, JM Lally, JSV Nero, TL Parker, MW Ask, K Scott, JW Jiang, L Pare, G Pinkosky, SL Steinberg, GR