Publications by Researcher: Steinberg, GR

Year	Title	Author(s)
2012	Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance Diabetologia	Palanivel, R Fullerton, MD Galic, S Honeyman, J Hewitt, KA Jorgensen, SB Steinberg, GR
2012	The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase Science	Hawley, SA Fullerton, MD Ross, FA Schertzer, JD Chevtzoff, C Walker, KJ Peggie, MW Zibrova, D Green, KA Mustard, KJ Kemp, BE Sakamoto, K Steinberg, GR Hardie, DG
2013	AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity Molecular And Cellular Endocrinology	O’Neill, HM Holloway, GP Steinberg, GR
2013	Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity Diabetes	Jorgensen, SB O’Neill, HM Sylow, L Honeyman, J Hewitt, KA Palanivel, R Fullerton, MD Oberg, L Balendran, A Galic, S van der Poel, C Trounce, IA Lynch, GS Schertzer, JD Steinberg, GR
2013	Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin Nature Medicine	Fullerton, MD Galic, S Marcinko, K Sikkema, S Pulinilkunnil, T Chen, ZP O’Neill, HM Ford, RJ Palanivel, R O’Brien, M Hardie, DG Macaulay, SL Schertzer, JD Dyck, JRB van Denderen, B Kemp, BE Steinberg, GR
2014	Hepatic Glucose Intolerance Precedes Hepatic Steatosis in the Male Aromatase Knockout (ArKO) Mouse Plos One	Van Sinderen, ML Steinberg, GR Jorgensen, SB To, SQ Knower, KC Clyne, CD Honeyman, J Chow, JD Herridge, KA Jones, MEE Simpson, ER Boon, WC
2014	Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity Biochemical Journal	Galic, S Sachithanandan, N Kay, TW Steinberg, GR
2014	Reduced skeletal muscle AMPK and mitochondrial markers do not promote age-induced insulin resistance Journal Of Applied Physiology	Bujak, AL Blumer, RME Marcinko, K Fullerton, MD Kemp, BE Steinberg, GR
2014	Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662 American Journal Of Physiology-endocrinology And Metabolism	Ducommun, S Ford, RJ Bultot, L Deak, M Bertrand, L Kemp, BE Steinberg, GR Sakamoto, K
2014	Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress Faseb Journal	McGee, SL Swinton, C Morrison, S Gaur, V Campbell, DE Jorgensen, SB Kemp, BE Baar, K Steinberg, GR Hargreaves, M
2014	Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling Chemistry & Biology	Scott, JW Ling, NM Issa, SMA Dite, TA O’Brien, MT Chen, ZP Galic, S Langendorf, CG Steinberg, GR Kemp, BE Oakhill, JS
2014	PPAR delta activation attenuates hepatic steatosis in Ldlr(-/-) mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity Journal Of Lipid Research	Bojic, LA Telford, DE Fullerton, MD Ford, RJ Sutherland, BG Edwards, JY Sawyez, CG Gros, R Kemp, BE Steinberg, GR Huff, MW
2014	Muscle-specific AMPK beta 1 beta 2-null mice display a myopathy due to loss of capillary density in nonpostural muscles Faseb Journal	Thomas, MM Wang, DC D’Souza, DM Krause, MP Layne, AS Criswell, DS O’Neill, HM Connor, MK Anderson, JE Kemp, BE Steinberg, GR Hawke, TJ
2014	AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice Diabetologia	O’Neill, HM Lally, JS Galic, S Thomas, M Azizi, PD Fullerton, MD Smith, BK Pulinilkunnil, T Chen, ZP Samaan, MC Jorgensen, SB Dyck, JRB Holloway, GP Hawke, TJ van Denderen, B Kemp, BE Steinberg, GR
2015	Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release Chem Biol	Kay, TW Ling, NXY Thomas, HE Foitzik, R Weng, QP Kemp, BE Graham, KL Langendorf, CG Steinberg, GR Galic, S Issa, SMA Birnberg, NC Scott, JW Dite, TA Oakhill, JS
2015	Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice Plos One	Van Sinderen, ML Steinberg, GR Jorgensen, SB Honeyman, J Chow, JD Herridge, KA Winship, AL Dimitriadis, E Jones, MEE Simpson, ER Boon, WC
2015	High intensity interval training improves liver and adipose tissue insulin sensitivity Mol. Metab.	Marcinko, K Sikkema, SR Samaan, MC Kemp, BE Fullerton, MD Steinberg, GR
2015	Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging Aging Cell	Crane, JD MacNeil, LG Lally, JS Ford, RJ Bujak, AL Brar, IK Kemp, BE Raha, S Steinberg, GR Tarnopolsky, MA
2015	Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis Biochem. J.	O’Brien, AJ Villani, LA Broadfield, LA Houde, VP Galic, S Blandino, G Kemp, BE Tsakiridis, T Muti, P Steinberg, GR
2015	AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism Cardiovasc. Res.	Sung, MM Zordoky, BN Bujak, AL Lally, JSV Fung, D Young, ME Horman, S Miller, EJ Light, PE Kemp, BE Steinberg, GR Dyck, JRB
2015	AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging Cell Metab.	Bujak, AL Crane, JD Lally, JS Ford, RJ Kang, SJ Rebalka, IA Green, AE Kemp, BE Hawke, TJ Schertzer, JD Steinberg, GR
2015	The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice Mol. Metab.	Marcinko, K Bujak, AL Lally, JSV Ford, RJ Wong, TH Smith, BK Kemp, BE Jenkins, Y Li, W Kinsella, TM Hitoshi, Y Steinberg, GR
2015	Salicylate improves macrophage cholesterol homeostasis via activation of Ampk Journal Of Lipid Research	Fullerton, MD Ford, RJ McGregor, CP LeBlond, ND Snider, SA Stypa, SA Day, EA Lhotak, S Schertzer, JD Austin, RC Kemp, BE Steinberg, GR
2015	Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release Chem. Biol.	Scott, JW Galic, S Graham, KL Foitzik, R Ling, NXY Dite, TA Issa, SMA Langendorf, CG Weng, QP Thomas, HE Kay, TW Birnberg, NC Steinberg, GR Kemp, BE Oakhill, JS
2015	Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity Biochem. J.	Ford, RJ Fullerton, MD Pinkosky, SL Day, EA Scott, JW Oakhill, JS Bujak, AL Smith, BK Crane, JD Blumer, RM Marcinko, K Kemp, BE Gerstein, HC Steinberg, GR
2016	Exercise reverses age-related vulnerability of the retina to injury by preventing complement-mediated synapse elimination via a BDNF-dependent pathway Aging Cell	Chrysostomou, V Galic, S van Wijngaarden, P Trounce, IA Steinberg, GR Crowston, JG
2016	Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-beta 1 Diabetes	Smith, BK Ford, RJ Desjardins, EM Green, AE Hughes, MC Houde, VP Day, EA Marcinko, K Crane, JD Mottillo, EP Perry, CGR Kemp, BE Tarnopolsky, MA Steinberg, GR
2016	Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function Cell Metab.	Mottillo, EP Desjardins, EM Crane, JD Smith, BK Green, AE Ducommun, S Henriksen, TI Rebalka, IA Razi, A Sakamoto, K Scheele, C Kemp, BE Hawke, TJ Ortega, J Granneman, JG Steinberg, GR
2016	An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice Nat. Med.	Rohm, M Schafer, M Laurent, V Ustunel, BE Niopek, K Algire, C Hautzinger, O Sijmonsma, TP Zota, A Medrikova, D Pellegata, NS Ryden, M Kulyte, A Dahlman, I Arner, P Petrovic, N Cannon, B Amri, EZ Kemp, BE Steinberg, GR Janovska, P Kopecky, J Wolfrum, C Bluher, M Diaz, MB Herzig, S
2017	The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs Nat. Commun.	Dite, TA Ling, NXY Scott, JW Hoque, A Galic, S Parker, BL Ngoei, KRW Langendorf, CG O’Brien, MT Kundu, M Viollet, B Steinberg, GR Sakamoto, K Kemp, BE Oakhill, JS
2017	AMPK beta 1 reduces tumor progression and improves survival in p53 null mice Mol. Oncol.	Houde, VP Donzelli, S Sacconi, A Galic, S Hammill, JA Bramson, JL Foster, RA Tsakiridis, T Kemp, BE Grasso, G Blandino, G Muti, P Steinberg, GR
2018	AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis Elife	Galic, S Loh, K Murray-Segal, L Steinberg, GR Andrews, ZB Kemp, BE
2018	AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation Blood	Lepropre, S Kautbally, S Octave, M Ginion, A Onselaer, MB Steinberg, GR Kemp, BE Hego, A Wera, O Brouns, S Swieringa, F Giera, M Darley-Usmar, VM Ambroise, J Guigas, B Heemskerk, J Bertrand, L Oury, C Beauloye, C Horman, S
2018	Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo Nat. Med.	Madiraju, AK Qiu, Y Perry, RJ Rahimi, Y Zhang, XM Zhang, DY Camporez, JPG Cline, GW Butrico, GM Kemp, BE Casals, G Steinberg, GR Vatner, DF Petersen, KF Shulman, GI
2019	Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance Hepatol. Commun.	Loh, K Tam, S Murray-Segal, L Huynh, K Meikle, PJ Scott, JW van Denderen, B Chen, ZP Steel, R LeBlond, ND Burkovsky, LA O’Dwyer, C Nunes, JRC Steinberg, GR Fullerton, MD Galic, S Kemp, BE
2020	Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue Biochemical Journal	Hussain, N Chuang, SJ Johanns, M Vertommen, D Steinberg, GR Kemp, BE Rider, MH
2020	Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK beta 1 isoforms Nature Metabolism	Pinkosky, SL Scott, JW Desjardins, EM Smith, BK Day, EA Ford, RJ Langendorf, CG Ling, NXY Nero, TL Loh, K Galic, S Hoque, A Smiles, WJ Ngoei, KRW Parker, MW Yan, Y Melcher, K Kemp, BE Oakhill, JS Steinberg, GR
2021	AMPK activation by SC4 inhibits noradrenaline- induced lipolysis and insulin-stimulated lipogenesis in white tissue Biochemical Journal	Chuang, SJ Johanns, M Ruys, SPD Steinberg, GR Kemp, BE Viollet, B Rider, MH
2021	AMPK mediates energetic stress-induced liver GDF15 Faseb Journal	Townsend, LK Weber, AJ Day, EA Shamshoum, H Shaw, SJ Perry, CGR Kemp, BE Steinberg, GR Wright, DC
2021	Salsalate reduces atherosclerosis through AMPK beta 1 in mice Molecular Metabolism	Day, EA Ford, RJ Smith, BK Ronde, VP Stypa, S Rehal, S Lhotak, S Kemp, BE Trigatti, BL Werstuck, GH Austin, RC Fullerton, MD Steinberg, GR
2021	Compound- and fiber type-selective requirement of AMPKy3 for insulin-independent glucose uptake in skeletal muscle Molecular Metabolism	Rhein, P Desjardins, EM Rong, P Ahwazi, D Bonhoure, N Stolte, J Santos, MD Ovens, AJ Ehrlich, AM Garcia, JLS Ouyang, Q Yabut, JM Membrez, M Kjolby, M Jessen, N Oakhill, JS Treebak, JT Maire, P Scott, JW Sanders, MJ Descombes, P Chen, S Steinberg, GR Sakamoto, K
2022	Blocking AMPK?1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis Cell Reports	Neopane, K Kozlov, N Negoita, F Murray-Segal, L Brink, R Hoque, A Ovens, AJ Tjin, G McAloon, LM Yu, DY Ling, NXY Sanders, MJ Oakhill, JS Scott, JW Steinberg, GR Loh, K Kemp, BE Sakamoto, K Galic, S
2022	Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia Cell Metabolism	Morrow, MR Batchuluun, B Wu, JH Ahmadi, E Leroux, JM Mohammadi-Shemirani, P Desjardins, EM Wang, ZC Tsakiridis, EE Lavoie, DCT Reihani, A Smith, BK Kwiecien, JM Lally, JSV Nero, TL Parker, MW Ask, K Scott, JW Jiang, L Pare, G Pinkosky, SL Steinberg, GR