Publications by Researcher: Mannering, SI

2012 Extraction of tissue antigens for functional assays
J Vis Exp
Chand, R Necula, AS Albatat, B Mannering, SI
2012 Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors
International Immunology
Joffe, M Necula, AS Chand, R McWhinney, BC Krishnamurthy, B Loudovaris, T Goodman, D Thomas, HE Kay, TWH Mannering, SI
2012 Biased T Cell Receptor Usage Directed against Human Leukocyte Antigen DQ8-Restricted Gliadin Peptides Is Associated with Celiac Disease
Broughton, SE Petersen, J Theodossis, A Scally, SW Loh, KL Thompson, A van Bergen, J Kooy-Winkelaar, Y Henderson, KN Beddoe, T Tye-Din, JA Mannering, SI Purcell, AW McCluskey, J Anderson, RP Koning, F Reid, HH Rossjohn, J
2013 Ara h 1 CD4+T cell epitope-based peptides: candidates for a peanut allergy therapeutic
Clinical And Experimental Allergy
Prickett, SR Voskamp, AL Phan, T Dacumos-Hill, A Mannering, SI Rolland, JM O’Hehir, RE
2013 Rapid and Unidirectional Perforin Pore Delivery at the Cytotoxic Immune Synapse
Journal Of Immunology
Lopez, JA Jenkins, MR Rudd-Schmidt, JA Brennan, AJ Danne, JC Mannering, SI Trapani, JA Voskoboinik, I
2014 Congenic mice reveal genetic epistasis and overlapping disease loci for autoimmune diabetes and listeriosis
Wang, N Elso, CM Mackin, L Mannering, SI Strugnell, RA Wijburg, OL Brodnicki, TC
2015 Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time
Journal Of Experimental Medicine
Jenkins, MR Rudd-Schmidt, JA Lopez, JA Ramsbottom, KM Mannering, SI Andrews, DM Voskoboinik, I Trapani, JA
2015 Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate
Eur. J. Immunol.
Zhao, YX Scott, NA Quah, HS Krishnamurthy, B Bond, F Loudovaris, T Mannering, SI Kay, TWH Thomas, HE
2015 Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer-Restricted CD4(+) T Cells Infiltrate Islets in Type 1 Diabetes
Pathiraja, V Kuehlich, JP Campbell, PD Krishnamurthy, B Loudovaris, T Coates, PTH Brodnicki, TC O’Connell, PJ Kedzierska, K Rodda, C Bergman, P Hill, E Purcell, AW Dudek, NL Thomas, HE Kay, TWH Mannering, SI
2016 The case for an autoimmune aetiology of type 1 diabetes
Clin. Exp. Immunol.
Mannering, SI Pathiraja, V Kay, TWH
2016 Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
Delong, T Wiles, TA Baker, RL Bradley, B Barbour, G Reisdorph, R Armstrong, M Powell, RL Reisdorph, N Kumar, N Elso, CM DeNicola, M Bottino, R Powers, AC Harlan, DM Kent, SC Mannering, SI Haskins, K
2017 Deciphering the Pathogenesis of Human Type 1 Diabetes (T1D) by Interrogating T Cells from the "Scene of the Crime"
Curr. Diabetes Rep.
Kent, SC Mannering, SI Michels, AW Babon, JAB
2017 Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice
Trivedi, PM Graham, KL Scott, NA Jenkins, MR Majaw, S Sutherland, RM Fynch, S Lew, AM Burns, CJ Krishnamurthy, B Brodnicki, TC Mannering, SI Kay, TW Thomas, HE
2018 Shuffling peptides to create T-cell epitopes: does the immune system play cards?
Immunol. Cell Biol.
Mannering, SI So, M Elso, CM Kay, TWH
2018 IFN gamma-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4(+) T Cell Migration
Front. Immunol.
Scott, NA Zhao, YX Krishnamurthy, B Mannering, SI Kay, TWH Thomas, HE
2018 Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles
J. Clin. Invest.
Pizzolla, A Nguyen, THO Sant, S Jaffar, J Loudovaris, T Mannering, SI Thomas, PG Westall, GP Kedzierska, K Wakim, LM
2018 Single-Cell Approach to Influenza Specific CD8(+) T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection
Front. Immunol.
Sant, S Grzelak, L Wang, ZF Pizzollal, A Koutsakos, M Crowe, J Loudoyaris, T Mannering, SI Westall, GP Wakiml, LM Rossjohn, J Gras, S Richards, M Xu, JQ Thomas, PG Loh, L Nguyen, TH Kedzierska, K
2018 Proinsulin C-peptide is an autoantigen in people with type 1 diabetes
Proc. Natl. Acad. Sci. U. S. A.
So, M Elso, CM Tresoldi, E Pakusch, M Pathiraja, V Wentworth, JM Harrison, LC Krishnamurthy, B Thomas, HE Rodda, C Cameron, FJ McMahon, J Kay, TWH Mannering, SI
2018 Circulating T-FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity
Sci. Transl. Med.
Koutsakos, M Wheatley, AK Loh, L Clemens, EB Sant, S Nussing, S Fox, A Chung, AW Laurie, KL Hurt, AC Rockman, S Lappas, M Loudovaris, T Mannering, SI Westall, GP Elliot, M Tangye, SG Wakim, LM Kent, SJ Nguyen, THO Kedzierska, K
2019 Neoepitopes: a new take on beta cell autoimmunity in type 1 diabetes
Mannering, SI Di Carluccio, AR Elso, CM
2019 Quantification of Proliferating Human Antigen-specific CD4(+)T Cells using Carboxyfluorescein Succinimidyl Ester
Jove-journal Of Visualized Experiments
Di Carluccio, AR Tresoldi, E So, M Mannering, SI
2019 Divergent SATB1 expression across human life span and tissue compartments
Immunology And Cell Biology
Nussing, S Koay, HF Sant, S Loudovaris, T Mannering, SI Lappas, M d’Udekem, Y Konstantinov, IE Berzins, SP Rimmelzwaan, GF Turner, SJ Clemens, EB Godfrey, DI Nguyen, TH Kedzierska, K
2019 Replacing murine insulin 1 with human insulin protects NOD mice from diabetes
Plos One
Elso, CM Scott, NA Mariana, L Masterman, EI Sutherland, APR Thomas, HE Mannering, SI
2019 Induced pluripotent stem cell macrophages present antigen to proinsulin-specific T cell receptors from donor-matched islet-infiltrating T cells in type 1 diabetes
Joshi, K Elso, C Motazedian, A Labonne, T Schiesser, JV Cameron, F Mannering, SI Elefanty, AG Stanley, EG
2019 Human gamma delta T-cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation
Clinical & Translational Immunology
Sant, S Jenkins, MR Dash, P Watson, KA Wang, ZF Pizzolla, A Koutsakos, M Nguyen, THO Lappas, M Crowe, J Loudovaris, T Mannering, SI Westall, GP Kotsimbos, TC Cheng, AC Wakim, L Doherty, PC Thomas, PG Loh, L Kedzierska, K
2019 Human CD8(+) T cell cross-reactivity across influenza A, B and C viruses
Nat. Immunol.
Koutsakos, M Illing, PT Nguyen, THO Mifsud, NA Crawford, JC Rizzetto, S Eltahla, AA Clemens, EB Sant, S Chua, BY Wong, CY Allen, EK Teng, D Dash, P Boyd, DF Grzelak, L Zeng, WG Hurt, AC Barr, I Rockman, S Jackson, DC Kotsimbos, TC Cheng, AC Richards, M Westall, GP Loudovaris, T Mannering, SI Elliott, M Tangye, SG Wakim, LM Rossjohn, J Vijaykrishna, D Luciani, F Thomas, PG Gras, S Purcell, AW Kedzierska, K
2020 HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8(+)T cells
Plos Pathogens
Sant, S Quinones-Parra, SM Koutsakos, M Grant, EJ Loudovaris, T Mannering, SI Crowe, J van de Sandt, CE Rimmelzwaan, GF Rossjohn, J Gras, S Loh, L Nguyen, THO Kedzierska, K
2020 Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes
Science Immunology
Bedford, JG Heinlein, M Garnham, AL Nguyen, THO Loudovaris, T Ge, CH Mannering, SI Elliott, M Tangye, SG Kedzierska, K Gray, DHD Heath, WR Wakim, LM
2021 Insulin's other life: an autoantigen in type 1 diabetes
Immunology And Cell Biology
Mannering, SI Bhattacharjee, P
2021 Identifying New Hybrid Insulin Peptides (HIPs) in Type 1 Diabetes
Frontiers In Immunology
Mannering, SI Rubin, AF Wang, RK Bhattacharjee, P
2021 It all started with the discovery of insulin
Immunology And Cell Biology
Mannering, SI
2021 Modeling Type 1 Diabetes Using Pluripotent Stem Cell Technology
Frontiers In Endocrinology
Joshi, K Cameron, F Tiwari, S Mannering, SI Elefanty, AG Stanley, EG
2021 T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
Nature Communications
Tran, MT Faridi, P Lim, JJ Ting, YT Onwukwe, G Bhattacharjee, P Jones, CM Tresoldi, E Cameron, FJ La Gruta, NL Purcell, AW Mannering, SI Rossjohn, J Reid, HH
2021 CD8(+) T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph
Nature Communications
Hensen, L Illing, PT Clemens, EB Nguyen, THO Koutsakos, M van de Sandt, CE Mifsud, NA Nguyen, AT Szeto, C Chua, BY Halim, H Rizzetto, S Luciani, F Loh, L Grant, EJ Saunders, PM Brooks, AG Rockman, S Kotsimbos, TC Cheng, AC Richards, M Westall, GP Wakim, LM Loudovaris, T Mannering, SI Elliott, M Tangye, SG Jackson, DC Flanagan, KL Rossjohn, J Gras, S Davies, J Miller, A Tong, SYC Purcell, AW Kedzierska, K