Publications by Researcher: Fynch, S

Year	Title	Author(s)
2012	Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression European Journal Of Immunology	Graham, KL Krishnamurthy, B Fynch, S Ayala-Perez, R Slattery, RM Santamaria, P Thomas, HE Kay, TWH
2012	Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells Diabetes	Krishnamurthy, B Chee, J Jhala, G Fynch, S Graham, KL Santamaria, P Morahan, G Allison, J Izon, D Thomas, HE Kay, TWH
2013	The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin-Induced Diabetes in Mice Diabetes	Chia, JSJ McRae, JL Thomas, HE Fynch, S Elkerbout, L Hill, P Murray-Segal, L Robson, SC Chen, JF d’Apice, AJF Cowan, PJ Dwyer, KM
2014	Activation of the NLRP3 Inflammasome Complex is Not Required for Stress-Induced Death of Pancreatic Islets Plos One	Wali, JA Gurzov, EN Fynch, S Elkerbout, L Kay, TW Masters, SL Thomas, HE
2014	Deficiency in Type I Interferon Signaling Prevents the Early Interferon-Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice Diabetes	Quah, HS Miranda-Hernandez, S Khoo, A Harding, A Fynch, S Elkerbout, L Brodnicki, TC Baxter, AG Kay, TWH Thomas, HE Graham, KL
2014	The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity Cell Death & Disease	Wali, JA Rondas, D McKenzie, MD Zhao, Y Elkerbout, L Fynch, S Gurzov, EN Akira, S Mathieu, C Kay, TWH Overbergh, L Strasser, A Thomas, HE
2015	Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes Diabetologia	Zhao, YX Scott, NA Fynch, S Elkerbout, L Wong, WWL Mason, KD Strasser, A Huang, DC Kay, TWH Thomas, HE
2016	Perforin facilitates beta cell killing and regulates autoreactive CD8+ T cell responses to antigen in mouse models of type 1 dia Immunol Cell Biol	Fynch, S Krishnamurthy, B Graham, KL Trivedi, P Kay, TW Slattery, RM Thomas, HE
2017	Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice Diabetes	Trivedi, PM Graham, KL Scott, NA Jenkins, MR Majaw, S Sutherland, RM Fynch, S Lew, AM Burns, CJ Krishnamurthy, B Brodnicki, TC Mannering, SI Kay, TW Thomas, HE
2017	Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway Diabetes	Mollah, ZUA Quah, HS Graham, KL Jhala, G Krishnamurthy, B Dharma, JFM Chee, J Trivedi, PM Pappas, EG Mackin, L Chu, EPF Akazawa, S Fynch, S Hodson, C Deans, AJ Trapani, JA Chong, MMW Bird, PI Brodnicki, TC Thomas, HE Kay, TWH
2019	Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice Cell Death Discovery	Trivedi, PM Fynch, S Kennedy, LM Chee, J Krishnamurthy, B O’Reilly, LA Strasser, A Kay, TWH Thomas, HE
2019	IL-21 regulates SOCS1 expression in autoreactive CD8(+) T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice Scientific Reports	Sutherland, APR Graham, KL Papadimitriou, M Jhala, G Trivedi, P Catterall, T Fynch, S Kay, TWH Thomas, HE
2020	IL-17F induces inflammation, dysfunction and cell death in mouse islets Scientific Reports	Catterall, T Fynch, S Kay, TWH Thomas, HE Sutherland, APR
2020	The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-gamma and Common gamma Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice Frontiers In Immunology	Ge, TT Jhala, G Fynch, S Akazawa, S Litwak, S Pappas, EG Catterall, T Vakil, I Long, AJ Olson, LM Krishnamurthy, B Kay, TW Thomas, HE
2020	ABCA12 regulates insulin secretion from beta-cells Embo Reports	Ursino, GM Fu, Y Cottle, DL Mukhamedova, N Jones, LK Low, H Tham, MS Gan, WJ Mellett, NA Das, PP Weir, JM Ditiatkovski, M Fynch, S Thorn, P Thomas, HE Meikle, PJ Parkington, HC Smyth, IM Sviridov, D
2021	Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice Diabetologia	Akazawa, S Mackin, L Jhala, G Fynch, S Catterall, T Selck, C Graham, KL Krishnamurthy, B Pappas, EG Kwong, CTJ Sutherland, APR Kay, TWH Brodnicki, TC Thomas, HE
2022	Neuropeptide Y1 receptor antagonism protects beta-cells and improves glycemic control in type 2 diabetes Molecular Metabolism	Yang, CH Ann-Onda, D Lin, XZ Fynch, S Nadarajah, S Pappas, EG Liu, X Scott, JW Oakhill, JS Galic, S Shi, YC Moreno-Asso, A Smith, C Loudovaris, T Levinger, I Eizirik, DL Laybutt, DR Herzog, H Thomas, HE Loh, K