Publications by Researcher: Fynch, S

YearTitleAuthor(s)
2012 Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression
European Journal Of Immunology
Graham, KL Krishnamurthy, B Fynch, S Ayala-Perez, R Slattery, RM Santamaria, P Thomas, HE Kay, TWH
2012 Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells
Diabetes
Krishnamurthy, B Chee, J Jhala, G Fynch, S Graham, KL Santamaria, P Morahan, G Allison, J Izon, D Thomas, HE Kay, TWH
2013 The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin-Induced Diabetes in Mice
Diabetes
Chia, JSJ McRae, JL Thomas, HE Fynch, S Elkerbout, L Hill, P Murray-Segal, L Robson, SC Chen, JF d’Apice, AJF Cowan, PJ Dwyer, KM
2014 Activation of the NLRP3 Inflammasome Complex is Not Required for Stress-Induced Death of Pancreatic Islets
Plos One
Wali, JA Gurzov, EN Fynch, S Elkerbout, L Kay, TW Masters, SL Thomas, HE
2014 Deficiency in Type I Interferon Signaling Prevents the Early Interferon-Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice
Diabetes
Quah, HS Miranda-Hernandez, S Khoo, A Harding, A Fynch, S Elkerbout, L Brodnicki, TC Baxter, AG Kay, TWH Thomas, HE Graham, KL
2014 The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity
Cell Death & Disease
Wali, JA Rondas, D McKenzie, MD Zhao, Y Elkerbout, L Fynch, S Gurzov, EN Akira, S Mathieu, C Kay, TWH Overbergh, L Strasser, A Thomas, HE
2015 Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes
Diabetologia
Zhao, YX Scott, NA Fynch, S Elkerbout, L Wong, WWL Mason, KD Strasser, A Huang, DC Kay, TWH Thomas, HE
2016 Perforin facilitates beta cell killing and regulates autoreactive CD8+ T cell responses to antigen in mouse models of type 1 dia
Immunol Cell Biol
Graham, KL Trivedi, P Kay, TW Slattery, RM Fynch, S Krishnamurthy, B Thomas, HE
2017 Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice
Diabetes
Trivedi, PM Graham, KL Scott, NA Jenkins, MR Majaw, S Sutherland, RM Fynch, S Lew, AM Burns, CJ Krishnamurthy, B Brodnicki, TC Mannering, SI Kay, TW Thomas, HE
2017 Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway
Diabetes
Mollah, ZUA Quah, HS Graham, KL Jhala, G Krishnamurthy, B Dharma, JFM Chee, J Trivedi, PM Pappas, EG Mackin, L Chu, EPF Akazawa, S Fynch, S Hodson, C Deans, AJ Trapani, JA Chong, MMW Bird, PI Brodnicki, TC Thomas, HE Kay, TWH