Title: Long-term effects of islet transplantation
Authors: Holmes-Walker, DJ
Kay, TWH
Issue Year: 2016
Publisher LIPPINCOTT WILLIAMS & WILKINS
Series Curr. Opin. Organ Transpl.:
Abstract Purpose of reviewIslet transplantation has made great progress in recent years. This is a remarkable technical feat but raises the question of what the long-term benefits and risks are for type I diabetes recipients.Recent findingsGraft survival continues to improve, and recent multicenter studies show that islet transplantation is particularly effective to prevent hypoglycemic events even in those who do not become insulin-independent and to achieve excellent glycemic control. Concerns include histocompatability leucocyte antigen (HLA) sensitization and other risks including from immunosuppression that islet transplantation shares with other forms of allotransplantation.SummaryReversal of hypoglycemia unawareness and protection from severe hypoglycemia events are two of the main benefits of islet transplantation and they persist for the duration of graft function. Islet transplantation compares favorably with other therapies for those with hypoglycemia unawareness, although new technologies have not been tested head-to-head with transplantation. HLA sensitization increases with time after transplantation especially if immunosuppression is ceased and is a risk for those who may require future transplantation as well as being associated with loss of graft function.
URI: https://publications.svi.edu.au/publications/6513
Other Identifiers 10.1097/MOT.0000000000000355
Publication type Review