Title: Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes
Authors: Chee, J
Ko, HJ
Skowera, A
Jhala, G
Catterall, T
Graham, KL
Sutherland, RM
Thomas, HE
Lew, AM
Peakman, M
Kay, TWH
Krishnamurthy, B
Issue Year: 2014
Series JOURNAL OF IMMUNOLOGY: 192(2): 572-580
Abstract CD8(+) T cells are critical in human type 1 diabetes and in the NOD mouse. In this study, we elucidated the natural history of islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)-specific CD8(+) T cells in NOD diabetes using MHC-tetramer technology. IGRP(206-214)-specific T cells in the peripheral lymphoid tissue increased with age, and their numbers correlated with insulitis progression. IGRP(206-214)-specific T cells in the peripheral lymphoid tissue expressed markers of chronic Ag stimulation, and their numbers were stable after diagnosis of diabetes, consistent with their memory phenotype. IGRP(206-214)-specific T cells in NOD mice expand, acquire the phenotype of effector-memory T cells in the islets, and emigrate to the peripheral lymphoid tissue. Our observations suggest that enumeration of effector-memory T cells of multiple autoantigen specificities in the periphery of type 1 diabetic subjects could be a reliable reporter for progression of islet pathology.
URI: https://publications.svi.edu.au/publications/1746
Other Identifiers 10.4049/jimmunol.1302100
Publication type Article
Grant ID GNT0516700; GNT1037321; GNT1042735
Find it online http://www.jimmunol.org/content/192/2/572.full.pdf+html