Title: The Architecture and Evolution of Cancer Neochromosomes
Authors: Garsed, DW
Marshall, OJ
Corbin, VDA
Hsu, A
Di Stefano, L
Schroder, J
Li, J
Feng, ZP
Kim, BW
Kowarsky, M
Lansdell, B
Brookwell, R
Myklebost, O
Meza-Zepeda, L
Holloway, AJ
Pedeutour, F
Choo, KHA
Damore, MA
Deans, AJ
Papenfuss, AT
Thomas, DM
Issue Year: 2014
Publisher CELL PRESS
Series CANCER CELL: 26(5): 653-667
Abstract We isolated and analyzed, at single-nucleotide resolution, cancer-associated neochromosomes from well-and/or dedifferentiated liposarcomas. Neochromosomes, which can exceed 600 Mb in size, initially arise as circular structures following chromothripsis involving chromosome 12. The core of the neochromosome is amplified, rearranged, and corroded through hundreds of breakage-fusion-bridge cycles. Under selective pressure, amplified oncogenes are overexpressed, while coamplified passenger genes may be silenced epigenetically. New material may be captured during punctuated chromothriptic events. Centromeric corrosion leads to crisis, which is resolved through neocentromere formation or native centromere capture. Finally, amplification terminates, and the neochromosome core is stabilized in linear form by telomere capture. This study investigates the dynamic mutational processes underlying the life history of a special form of cancer mutation.
URI: https://publications.svi.edu.au/publications/1777
ISSN 1535-6108
Other Identifiers 10.1016/j.ccell.2014.09.010
Publication type Article
Grant ID GNT1031104
Find it online http://ac.els-cdn.com/S1535610814003730/1-s2.0-S1535610814003730-main.pdf?_tid=c37637dc-2f50-11e5-b18a-00000aab0f6c&acdnat=1437446142_b6e93146e42fbb405eac9884f26e6b04