Publications by Researcher: Walkley, CR

YearTitleAuthor(s)
2011 Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment
Blood. 117(21):5631-42
Liddicoat, B Jovic, T Russell, MR Singbrant, S Izon, DJ Purton, LE Sankaran, VG Martin, TJ Sims, NA Walkley, CR
2012 Genetically engineered mouse models and human osteosarcoma
Clin Sarcoma Res
Ng, AJM Baker, EK Mutsaers, AJ Walkley, CR
2012 The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim
Journal Of Experimental Medicine
Jurado, S Gleeson, K O’Donnell, K Izon, DJ Walkley, CR Strasser, A Tarlinton, DM Heierhorst, J
2013 Deciphering Hematopoietic Stem Cells in Their Niches: A Critical Appraisal of Genetic Models, Lineage Tracing, and Imaging Strategies
Cell Stem Cell
Joseph, C Quach, JM Walkley, CR Lane, SW Lo Celso, C Purton, LE
2013 Darbepoietin-alfa has comparable erythropoietic stimulatory effects to recombinant erythropoietin whilst preserving the bone marrow microenvironment
Haematologica
Dewamitta, SR Russell, MR Nandurkar, H Walkley, CR
2013 Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation
Journal Of Clinical Investigation
Kansara, M Leong, HS Lin, DM Popkiss, S Pang, PY Garsed, DW Walkley, CR Cullinane, C Ellul, J Haynes, NM Hicks, R Kuijjer, ML Cleton-Jansen, AM Hinds, PW Smyth, MJ Thomas, DM
2013 Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA
Bone
Mutsaers, AJ Ng, AJM Baker, EK Russell, MR Chalk, AM Wall, M Liddicoat, BJJ Ho, PWM Slavin, JL Goradia, A Martin, TJ Purton, LE Dickins, RA Walkley, CR
2014 PTHrP, its receptor, and protein kinase A activation in osteosarcoma
Molecular & Cellular Oncology
Ho, PW Walia, MK Walkley, CR Martin, TJ
2014 Cells of origin in osteosarcoma: Mesenchymal stem cells or osteoblast committed cells?
Bone
Mutsaers, AJ Walkley, CR
2014 Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors
British Journal Of Haematology
Dewamitta, SR Joseph, C Purton, LE Walkley, CR
2014 The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease
Haematologica
Singbrant, S Wall, M Moody, J Karlsson, G Chalk, AM Liddicoat, B Russell, MR Walkley, CR Karlsson, S
2014 The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis
Journal Of Clinical Investigation
Smeets, MF DeLuca, E Wall, M Quach, JM Chalk, AM Deans, AJ Heierhorst, J Purton, LE Izon, DJ Walkley, CR
2015 Ciliary neutrotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure.
Sci Rep
King, HA Walkley, CR Jovic, T Smeets, MF White, KE Baker, EK Askmyr, M Maluenda, AC Quach, JM Purton, LE
2015 Modeling osteosarcoma: in vitro and in vivo approaches
Bone Cancer: Primary Bone Cancer And Bone Metastases, 2nd Edition
Walkley, CR
2015 Src family kinases and their role in hematological malignancies
Leukemia & Lymphoma
Ku, M Wall, M MacKinnon, RN Walkley, CR Purton, LE Tam, C Izon, D Campbell, L Cheng, HC Nandurkar, H
2015 Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation
Stem Cells
Martin, SK Fitter, S Dutta, AK Matthews, MP Walkley, CR Hall, MN Ruegg, MA Gronthos, S Zannettino, ACW
2015 RAR gamma is a negative regulator of osteoclastogenesis
J. Steroid Biochem. Mol. Biol.
Green, AC Poulton, IJ Vrahnas, C Hausler, KD Walkley, CR Wu, JY Martin, TJ Gillespie, MT Chandraratna, RAS Quinn, JMW Sims, NA Purton, LE
2015 HIF-1 alpha is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1 alpha
Leukemia
Forristal, CE Nowlan, B Jacobsen, RN Barbier, V Walkinshaw, G Walkley, CR Winkler, IG Levesque, JP
2015 Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure
Cell Reports
Askmyr, M White, KE Jovic, T King, HA Quach, JM Maluenda, JC Baker, EK Smeets, MF Walkley, CR Purton, LE
2015 Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure
Sci Rep
Askmyr, M White, KE Jovic, T King, HA Quach, JM Maluenda, AC Baker, EK Smeets, MF Walkley, CR Purton, LE
2015 RNA EDITING RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself
Science
Liddicoat, BJ Piskol, R Chalk, AM Ramaswami, G Higuchi, M Hartner, JC Li, JB Seeburg, PH Walkley, CR
2015 The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation
Plos Genetics
Ng, AJM Walia, MK Smeets, MF Mutsaers, AJ Sims, NA Purton, LE Walsh, NC Martin, TJ Walkley, CR
2015 BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells
Sci Rep
Baker, EK Taylor, S Gupte, A Sharp, PP Walia, M Walsh, NC Zannettino, ACW Chalk, AM Burns, CJ Walkley, CR
2015 Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma
Bone
Baker, EK Taylor, S Gupte, A Chalk, AM Bhattacharya, S Green, AC Martin, TJ Strbenac, D Robinson, MD Purton, LE Walkley, CR
2015 Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo.
Oncogene
Ho, PW Goradia, A Russell, MR Chalk, AM Milley, KM Baker, EK Danks, JA Slavin, JL Walia, M Crimeen-Irwin, B Dickins, RA Martin, TJ Walkley, CR
2015 Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo
Oncogene
Ho, PWM Goradia, A Russell, MR Chalk, AM Milley, KM Baker, EK Danks, JA Slavin, JL Walia, M Crimeen-Irwin, B Dickins, RA Martin, TJ Walkley, CR
2015 Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma
Clin. Cancer Res.
Gupte, A Baker, EK Wan, SS Stewart, E Loh, A Shelat, AA Gould, CM Chalk, AM Taylor, S Lackovic, K Karlstrom, A Mutsaers, AJ Desai, J Madhamshettiwar, PB Zannettino, ACW Burns, C Huang, DCS Dyer, MA Simpson, KJ Walkley, CR
2015 Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Gupte, A Baker, EK Wan, SS Stewart, E Loh, A Shelat, AA Gould, CM Chalk, AM Taylor, S Lackovic, K Karlstrom, A Mutsaers, AJ Desai, J Madhamshettiwar, PB Zannettino, AC Burns, C Huang, DC Dyer, MA Simpson, KJ Walkley, CR
2016 Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during
Bone
Arthur, A Walkley, CR Nguyen, TM Codrington, JD Panagopoulos, R Hemming, S. Paton, S Zannettino, AC Gronthos, S
2016 The role of RNA editing by ADAR1 in prevention of innate immune sensing of self-RNA
J. Mol. Med.
Heraud-Farlow, JE Walkley, CR
2016 ADAR1, inosine and the immune sensing system: distinguishing self from non-self
Wiley Interdiscip. Rev.-rna
Liddicoat, BJ Chalk, AM Walkley, CR
2016 IAP antagonists sensitize murine osteosarcoma cells to killing by TNF alpha
Oncotarget
Shekhar, TM Miles, MA Gupte, A Taylor, S Tascone, B Walkley, CR Hawkins, CJ
2016 Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion
Cell Reports
Capellera-Garcia, S Pulecio, J Dhulipala, K Siva, K Rayon-Estrada, V Singbrant, S Sommarin, MNE Walkley, CR Soneji, S Karlsson, G Raya, A Sankaran, VG Flygare, J
2016 Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death
Oncogene
Bhattacharya, S Chalk, AM Ng, AJM Martin, TJ Zannettino, AC Purton, LE Lu, J Baker, EK Walkley, CR
2016 The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma
Cell Reports
Wong, DM Li, LL Jurado, S King, A Bamford, R Wall, M Walia, MK Kelly, GL Walkley, CR Tarlinton, DM Strasser, A Heierhorst, J
2016 Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis
Exp Hematol
Orkin, SH Liddicoat, BJ Kingsley, PD Palis, J Chalk, AM Seeburg, PH Ramaswami, G Purton, LE Li, JB Piskol, R Wall, M Lu, J Hartner, JC Sankaran, VG Walkley, CR
2016 PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells
Proc. Natl. Acad. Sci. U. S. A.
Chandrakanthan, V Yeola, A Kwan, JC Oliver, RA Qiao, Q Kang, YC Zarzour, P Beck, D Boelen, L Unnikrishnan, A Villanueva, JE Nunez, AC Knezevic, K Palu, C Nasrallah, R Carnell, M Macmillan, A Whan, R Yu, Y Hardy, P Grey, ST Gladbach, A Delerue, F Ittner, L Mobbs, R Walkley, CR Purton, LE Ward, RL Wong, JWH Hesson, LB Walsh, W Pimanda, JE
2017 Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
Genome Biol.
Walkley, CR Li, JB
2017 mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation
Mol. Cell. Biol.
Fitter, S Matthews, MP Martin, SK Xie, JL Ooi, SS Walkley, CR Codrington, JD Ruegg, MA Hall, MN Proud, CG Gronthos, S Zannettino, ACW
2017 The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation
Plos One
Wolwer, CB Godde, N Pase, LB Elsum, IA Lim, KYB Sacirbegovic, F Walkley, CR Ellis, S Ohno, S Matsuzaki, F Russell, SM Humbert, PO
2017 Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis
Genome Biol.
Heraud-Farlow, JE Chalk, AM Linder, SE Li, Q Taylor, S White, JM Pang, L Liddicoat, BJ Gupte, A Li, JB Walkley, CR
2017 Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors
Acs Med. Chem. Lett.
Sharp, PP Garnier, JM Hatfaludi, T Xu, Z Segal, D Jarman, KE Jousset, H Garnham, A Feutrill, JT Cuzzupe, A Hall, P Taylor, S Walkley, CR Tyler, D Dawson, MA Czabotar, P Wilks, AF Glaser, S Huang, DCS Burns, CJ
2017 Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress
Blood
Shi, W Vu, T Boucher, D Biernacka, A Nde, J Pandita, RK Straube, J Boyle, GM Al-Ejeh, F Nag, P Jeffery, J Harris, JL Bain, AL Grzelak, M Skrzypczak, M Mitra, A Dojer, N Crosetto, N Cloonan, N Becherel, OJ Finnie, J Skaar, JR Walkley, CR Pandita, TK Rowicka, M Ginalski, K Lane, SW Khanna, KK
2017 Dynamic landscape and regulation of RNA editing in mammals
Nature
Tan, MH Li, Q Shanmugam, R Piskol, R Kohler, J Young, AN Liu, KI Zhang, R Amaswami, GR Ariyoshi, K Gupte, A Keegan, LP George, CX Amu, AR Huang, N Pollina, EA Leeman, DS Ustighi, AR Goh, YPS Hawla, AC Del Sal, G Peltz, G Runet, AB Onrad, DFC Samuel, CE O’Connell, MA Walkley, CR Nishikura, K Li, JB
2018 Small animal models for the study of bone sarcoma pathogenesis: characteristics, therapeutic interests and limitations
J. Bone Oncol.
Jacques, C Renema, N Lezot, F Ory, B Walkley, CR Grigoriadis, AE Heymann, D
2018 mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis
Sci Rep
Martin, SK Fitter, S El Khawanky, N Grose, RH Walkley, CR Purton, LE Ruegg, MA Hall, MN Gronthos, S Zannettino, ACW
2018 Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53
Cell Death Dis.
Walia, MK Taylor, S Ho, PWM Martin, TJ Walkley, CR
2018 Murine models of osteosarcoma: A piece of the translational puzzle
J. Cell. Biochem.
Walia, MK Castillo-Tandazo, W Mutsaers, AJ Martin, TJ Walkley, CR
2018 ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity
Embo Rep.
Nakahama, T Kato, Y Kim, JI Vongpipatana, T Suzuki, Y Walkley, CR Kawahara, Y
2018 Srsf2(P95H) initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells
Blood
Smeets, MF Tan, SY Xu, JJ Anande, G Unnikrishnan, A Chalk, AM Taylor, SR Pimanda, JE Wall, M Purton, LE Walkley, CR
2018 Adar3 Is Involved in Learning and Memory in Mice
Front. Neurosci.
Mladenova, D Barry, G Konen, LM Pineda, SS Guennewig, B Avesson, L Zinn, R Schonrock, N Bitar, M Jonkhout, N Crumlish, L Kaczorowski, DC Gong, A Pinese, M Franco, GR Walkley, CR Vissel, B Mattick, JS
2019 Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal
Exp. Hematol.
Xu, JJ Srneets, MF Tan, SY Wall, M Purton, LE Walkley, CR