Publications by Researcher: Walkley, CR

Year	Title	Author(s)
2011	Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment Blood. 117(21):5631-42	Liddicoat, B Jovic, T Russell, MR Singbrant, S Izon, DJ Purton, LE Sankaran, VG Martin, TJ Sims, NA Walkley, CR
2012	Genetically engineered mouse models and human osteosarcoma Clin Sarcoma Res	Ng, AJM Baker, EK Mutsaers, AJ Walkley, CR
2012	The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim Journal Of Experimental Medicine	Jurado, S Gleeson, K O’Donnell, K Izon, DJ Walkley, CR Strasser, A Tarlinton, DM Heierhorst, J
2013	Deciphering Hematopoietic Stem Cells in Their Niches: A Critical Appraisal of Genetic Models, Lineage Tracing, and Imaging Strategies Cell Stem Cell	Joseph, C Quach, JM Walkley, CR Lane, SW Lo Celso, C Purton, LE
2013	Darbepoietin-alfa has comparable erythropoietic stimulatory effects to recombinant erythropoietin whilst preserving the bone marrow microenvironment Haematologica	Dewamitta, SR Russell, MR Nandurkar, H Walkley, CR
2013	Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation Journal Of Clinical Investigation	Kansara, M Leong, HS Lin, DM Popkiss, S Pang, PY Garsed, DW Walkley, CR Cullinane, C Ellul, J Haynes, NM Hicks, R Kuijjer, ML Cleton-Jansen, AM Hinds, PW Smyth, MJ Thomas, DM
2013	Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA Bone	Mutsaers, AJ Ng, AJM Baker, EK Russell, MR Chalk, AM Wall, M Liddicoat, BJJ Ho, PWM Slavin, JL Goradia, A Martin, TJ Purton, LE Dickins, RA Walkley, CR
2014	PTHrP, its receptor, and protein kinase A activation in osteosarcoma Molecular & Cellular Oncology	Ho, PW Walia, MK Walkley, CR Martin, TJ
2014	Cells of origin in osteosarcoma: Mesenchymal stem cells or osteoblast committed cells? Bone	Mutsaers, AJ Walkley, CR
2014	Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors British Journal Of Haematology	Dewamitta, SR Joseph, C Purton, LE Walkley, CR
2014	The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease Haematologica	Singbrant, S Wall, M Moody, J Karlsson, G Chalk, AM Liddicoat, B Russell, MR Walkley, CR Karlsson, S
2014	The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis Journal Of Clinical Investigation	Smeets, MF DeLuca, E Wall, M Quach, JM Chalk, AM Deans, AJ Heierhorst, J Purton, LE Izon, DJ Walkley, CR
2015	Ciliary neutrotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure. Sci Rep	Walkley, CR Jovic, T Smeets, MF White, KE Baker, EK Askmyr, M Maluenda, AC Quach, JM King, HA Purton, LE
2015	Modeling osteosarcoma: in vitro and in vivo approaches Bone Cancer: Primary Bone Cancer And Bone Metastases, 2nd Edition	Walkley, CR
2015	Src family kinases and their role in hematological malignancies Leukemia & Lymphoma	Ku, M Wall, M MacKinnon, RN Walkley, CR Purton, LE Tam, C Izon, D Campbell, L Cheng, HC Nandurkar, H
2015	Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation Stem Cells	Martin, SK Fitter, S Dutta, AK Matthews, MP Walkley, CR Hall, MN Ruegg, MA Gronthos, S Zannettino, ACW
2015	RAR gamma is a negative regulator of osteoclastogenesis J. Steroid Biochem. Mol. Biol.	Green, AC Poulton, IJ Vrahnas, C Hausler, KD Walkley, CR Wu, JY Martin, TJ Gillespie, MT Chandraratna, RAS Quinn, JMW Sims, NA Purton, LE
2015	HIF-1 alpha is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1 alpha Leukemia	Forristal, CE Nowlan, B Jacobsen, RN Barbier, V Walkinshaw, G Walkley, CR Winkler, IG Levesque, JP
2015	Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure Cell Reports	Askmyr, M White, KE Jovic, T King, HA Quach, JM Maluenda, JC Baker, EK Smeets, MF Walkley, CR Purton, LE
2015	RNA EDITING RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself Science	Liddicoat, BJ Piskol, R Chalk, AM Ramaswami, G Higuchi, M Hartner, JC Li, JB Seeburg, PH Walkley, CR
2015	The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation Plos Genetics	Ng, AJM Walia, MK Smeets, MF Mutsaers, AJ Sims, NA Purton, LE Walsh, NC Martin, TJ Walkley, CR
2015	Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure Sci Rep	Askmyr, M White, KE Jovic, T King, HA Quach, JM Maluenda, AC Baker, EK Smeets, MF Walkley, CR Purton, LE
2015	BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells Sci Rep	Baker, EK Taylor, S Gupte, A Sharp, PP Walia, M Walsh, NC Zannettino, ACW Chalk, AM Burns, CJ Walkley, CR
2015	Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma Bone	Baker, EK Taylor, S Gupte, A Chalk, AM Bhattacharya, S Green, AC Martin, TJ Strbenac, D Robinson, MD Purton, LE Walkley, CR
2015	Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo Oncogene	Ho, PWM Goradia, A Russell, MR Chalk, AM Milley, KM Baker, EK Danks, JA Slavin, JL Walia, M Crimeen-Irwin, B Dickins, RA Martin, TJ Walkley, CR
2015	Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo. Oncogene	Ho, PW Goradia, A Russell, MR Chalk, AM Milley, KM Baker, EK Danks, JA Slavin, JL Walia, M Crimeen-Irwin, B Dickins, RA Martin, TJ Walkley, CR
2015	Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma Clin. Cancer Res.	Gupte, A Baker, EK Wan, SS Stewart, E Loh, A Shelat, AA Gould, CM Chalk, AM Taylor, S Lackovic, K Karlstrom, A Mutsaers, AJ Desai, J Madhamshettiwar, PB Zannettino, ACW Burns, C Huang, DCS Dyer, MA Simpson, KJ Walkley, CR
2015	Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research	Gupte, A Baker, EK Wan, SS Stewart, E Loh, A Shelat, AA Gould, CM Chalk, AM Taylor, S Lackovic, K Karlstrom, A Mutsaers, AJ Desai, J Madhamshettiwar, PB Zannettino, AC Burns, C Huang, DC Dyer, MA Simpson, KJ Walkley, CR
2016	Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during Bone	Arthur, A Walkley, CR Nguyen, TM Codrington, JD Panagopoulos, R Hemming, S. Paton, S Zannettino, AC Gronthos, S
2016	The role of RNA editing by ADAR1 in prevention of innate immune sensing of self-RNA J. Mol. Med.	Heraud-Farlow, JE Walkley, CR
2016	ADAR1, inosine and the immune sensing system: distinguishing self from non-self Wiley Interdiscip. Rev.-rna	Liddicoat, BJ Chalk, AM Walkley, CR
2016	IAP antagonists sensitize murine osteosarcoma cells to killing by TNF alpha Oncotarget	Shekhar, TM Miles, MA Gupte, A Taylor, S Tascone, B Walkley, CR Hawkins, CJ
2016	Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion Cell Reports	Capellera-Garcia, S Pulecio, J Dhulipala, K Siva, K Rayon-Estrada, V Singbrant, S Sommarin, MNE Walkley, CR Soneji, S Karlsson, G Raya, A Sankaran, VG Flygare, J
2016	The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma Cell Reports	Wong, DM Li, LL Jurado, S King, A Bamford, R Wall, M Walia, MK Kelly, GL Walkley, CR Tarlinton, DM Strasser, A Heierhorst, J
2016	Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death Oncogene	Bhattacharya, S Chalk, AM Ng, AJM Martin, TJ Zannettino, AC Purton, LE Lu, J Baker, EK Walkley, CR
2016	Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis Exp Hematol	Liddicoat, BJ Kingsley, PD Palis, J Chalk, AM Seeburg, PH Ramaswami, G Purton, LE Li, JB Piskol, R Wall, M Lu, J Hartner, JC Sankaran, VG Orkin, SH Walkley, CR
2016	PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells Proc. Natl. Acad. Sci. U. S. A.	Chandrakanthan, V Yeola, A Kwan, JC Oliver, RA Qiao, Q Kang, YC Zarzour, P Beck, D Boelen, L Unnikrishnan, A Villanueva, JE Nunez, AC Knezevic, K Palu, C Nasrallah, R Carnell, M Macmillan, A Whan, R Yu, Y Hardy, P Grey, ST Gladbach, A Delerue, F Ittner, L Mobbs, R Walkley, CR Purton, LE Ward, RL Wong, JWH Hesson, LB Walsh, W Pimanda, JE
2017	Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs Genome Biol.	Walkley, CR Li, JB
2017	mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation Mol. Cell. Biol.	Fitter, S Matthews, MP Martin, SK Xie, JL Ooi, SS Walkley, CR Codrington, JD Ruegg, MA Hall, MN Proud, CG Gronthos, S Zannettino, ACW
2017	The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation Plos One	Wolwer, CB Godde, N Pase, LB Elsum, IA Lim, KYB Sacirbegovic, F Walkley, CR Ellis, S Ohno, S Matsuzaki, F Russell, SM Humbert, PO
2017	Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis Genome Biol.	Heraud-Farlow, JE Chalk, AM Linder, SE Li, Q Taylor, S White, JM Pang, L Liddicoat, BJ Gupte, A Li, JB Walkley, CR
2017	Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors Acs Med. Chem. Lett.	Sharp, PP Garnier, JM Hatfaludi, T Xu, Z Segal, D Jarman, KE Jousset, H Garnham, A Feutrill, JT Cuzzupe, A Hall, P Taylor, S Walkley, CR Tyler, D Dawson, MA Czabotar, P Wilks, AF Glaser, S Huang, DCS Burns, CJ
2017	Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress Blood	Shi, W Vu, T Boucher, D Biernacka, A Nde, J Pandita, RK Straube, J Boyle, GM Al-Ejeh, F Nag, P Jeffery, J Harris, JL Bain, AL Grzelak, M Skrzypczak, M Mitra, A Dojer, N Crosetto, N Cloonan, N Becherel, OJ Finnie, J Skaar, JR Walkley, CR Pandita, TK Rowicka, M Ginalski, K Lane, SW Khanna, KK
2017	Dynamic landscape and regulation of RNA editing in mammals Nature	Tan, MH Li, Q Shanmugam, R Piskol, R Kohler, J Young, AN Liu, KI Zhang, R Amaswami, GR Ariyoshi, K Gupte, A Keegan, LP George, CX Amu, AR Huang, N Pollina, EA Leeman, DS Ustighi, AR Goh, YPS Hawla, AC Del Sal, G Peltz, G Runet, AB Onrad, DFC Samuel, CE O’Connell, MA Walkley, CR Nishikura, K Li, JB
2018	Small animal models for the study of bone sarcoma pathogenesis: characteristics, therapeutic interests and limitations J. Bone Oncol.	Jacques, C Renema, N Lezot, F Ory, B Walkley, CR Grigoriadis, AE Heymann, D
2018	mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis Sci Rep	Martin, SK Fitter, S El Khawanky, N Grose, RH Walkley, CR Purton, LE Ruegg, MA Hall, MN Gronthos, S Zannettino, ACW
2018	Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53 Cell Death Dis.	Walia, MK Taylor, S Ho, PWM Martin, TJ Walkley, CR
2018	Murine models of osteosarcoma: A piece of the translational puzzle J. Cell. Biochem.	Walia, MK Castillo-Tandazo, W Mutsaers, AJ Martin, TJ Walkley, CR
2018	ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity Embo Rep.	Nakahama, T Kato, Y Kim, JI Vongpipatana, T Suzuki, Y Walkley, CR Kawahara, Y
2018	Srsf2(P95H) initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells Blood	Smeets, MF Tan, SY Xu, JJ Anande, G Unnikrishnan, A Chalk, AM Taylor, SR Pimanda, JE Wall, M Purton, LE Walkley, CR
2018	Adar3 Is Involved in Learning and Memory in Mice Front. Neurosci.	Mladenova, D Barry, G Konen, LM Pineda, SS Guennewig, B Avesson, L Zinn, R Schonrock, N Bitar, M Jonkhout, N Crumlish, L Kaczorowski, DC Gong, A Pinese, M Franco, GR Walkley, CR Vissel, B Mattick, JS
2019	Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the intrinsic apoptosis pathway Cell Death & Disease	Walkley, CR Kile, BT
2019	Osteosarcoma in the Post Genome Era: Preclinical Models and Approaches to Identify Tractable Therapeutic Targets Current Osteoporosis Reports	Castillo-Tandazo, W Mutsaers, AJ Walkley, CR
2019	Defining the functions of adenosine-to-inosine RNA editing through hematology Current Opinion In Hematology	Heraud-Farlow, JE Chalk, AM Walkley, CR
2019	The majority of A-to-I RNA editing is not required for mammalian homeostasis Genome Biology	Chalk, AM Taylor, S Heraud-Farlow, JE Walkley, CR
2019	Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal Exp. Hematol.	Xu, JJ Srneets, MF Tan, SY Wall, M Purton, LE Walkley, CR
2019	Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice Bmc Cancer	Shekhar, TM Burvenich, IJG Harris, MA Rigopoulos, A Zanker, D Spurling, A Parker, BS Walkley, CR Scott, AM Hawkins, CJ
2019	ATP-dependent helicase activity is dispensable for the physiological functions of Recql4 Plos Genetics	Castillo-Tandazo, W Smeets, MF Murphy, V Liu, R Hodson, C Heierhorst, J Deans, AJ Walkley, CR
2020	What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs Open Biology	Heraud-Farlow, JE Walkley, CR
2020	Enhancing mitochondrial function in vivo rescues MDS-like anemia induced by pRb deficiency Experimental Hematology	Sen, T Jain, M Gram, M Mattebo, A Soneji, S Walkley, CR Singbrant, S
2020	Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction Nature Neuroscience	Marshall, PR Zhao, QY Li, X Wei, W Periyakaruppiah, A Zajaczkowski, EL Leighton, LJ Madugalle, SU Basic, D Wang, ZQ Yin, JY Liau, WS Gupte, A Walkley, CR Bredy, TW
2020	Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia Nature Communications	Vu, T Straube, J Porter, AH Bywater, M Song, A Ling, V Cooper, L Pali, G Bruedigam, C Jacquelin, S Green, J Magor, G Perkins, A Chalk, AM Walkley, CR Heidel, FH Mukhopadhyay, P Cloonan, N Groschel, S Mallm, JP Frohling, S Scholl, C Lane, SW
2020	ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress Cell Stem Cell	Guallar, D Fuentes-Iglesias, A Souto, Y Ameneiro, C Freire-Agulleiro, O Pardavila, JA Escudero, A Garcia-Outeiral, V Moreira, T Saenz, C Xiong, H Liu, DB Xiao, SD Hou, Y Wu, K Torrecilla, D Hartner, JC Blanco, MG Lee, LJ Lopez, M Walkley, CR Wang, JL Fidalgo, M
2021	Rothmund-Thomson Syndrome-Like RECQL4 Truncating Mutations Cause a Haploinsufficient Low-Bone-Mass Phenotype in Mice Molecular And Cellular Biology	Castillo-Tandazo, W Frazier, AE Sims, NA Smeets, MF Walkley, CR
2022	Patience is a virtue Blood	Walkley, CR