Title: Darbepoietin-alfa has comparable erythropoietic stimulatory effects to recombinant erythropoietin whilst preserving the bone marrow microenvironment
Authors: Dewamitta, SR
Russell, MR
Nandurkar, H
Walkley, CR
Issue Year: 2013
Series HAEMATOLOGICA: 98(5): 686-690
Abstract Erythropoiesis stimulating agents are widely used for the treatment of anemia. Recently, we reported erythroid expansion with impaired B lymphopoiesis and loss of trabecular bone in C57BL/6 mice following ten days of treatment with low-dose short acting recombinant human erythropoietin. We have assessed erythropoietin against longer-acting darbepoietin-alfa at a comparable erythroid stimulatory dosage regime. Darbepoietin-alfa and erythropoietin induced similar in vivo erythropoietic expansion. Both agents induced an expansion of the colony-forming unit-erythroid populations. However, unlike erythropoietin, darbepoietin-alfa did not impair bone marrow B lymphopoiesis. Strikingly the bone loss observed with erythropoietin was not apparent following darbepoietin-alfa treatment. This analysis demonstrates that whilst darbepoietin-alfa has similar in vivo erythropoietic potency to erythropoietin, it preserves the bone marrow microenvironment. Thus erythropoietin and darbepoietin-alfa manifest different action showing that erythropoiesis stimulating agents have differential non-erythroid effects dependent on their duration of action.
URI: https://publications.svi.edu.au/publications/1678
ISSN 0390-6078
Other Identifiers 10.3324/haematol.2012.078709
Publication type Article
Grant ID GNT0559016; GNT1031481
Find it online http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640110/pdf/0980686.pdf