Title: Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors
Authors: Dewamitta, SR
Joseph, C
Purton, LE
Walkley, CR
Issue Year: 2014
Publisher WILEY-BLACKWELL
Series BRITISH JOURNAL OF HAEMATOLOGY: 164(2): 280-285
Abstract Vitamin A and its derivatives (retinoids) are important regulators of haematopoiesis, acting via retinoic acid receptors (RARs). Epidemiological studies indicated an association of vitamin A deficiency with anaemia in humans. To define the requirements of RARs in erythropoiesis, we evaluated erythroid parameters in RAR germ-line deficient and conditional knock out mice with erythroid specific deletion of RARs. Adult RAR(-/-) mice were anaemic, however, Epor-Cre Rara(fl/fl), Epor-Cre Rarg(fl/fl) and Epor-Cre Rara(fl/fl)g(fl/fl) mice were normal, indicating a lack of an erythroid intrinsic RAR function. Therefore, erythroid-specific RAR function is dispensable for erythropoiesis and RAR plays an erythroid extrinsic role in erythropoiesis.
URI: https://publications.svi.edu.au/publications/1796
Other Identifiers 10.1111/bjh.12578
Publication type Article
Grant ID GNT0559016; GNT1031481;GNT1003339; GNT1006485;