| Title: | The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma |
| Authors: | Wong, DM Li, LL Jurado, S King, A Bamford, R Wall, M Walia, MK Kelly, GL Walkley, CR Tarlinton, DM Strasser, A Heierhorst, J |
| Issue Year: | 2016 |
| Publisher | CELL PRESS |
| Series | Cell Reports: |
| Abstract | How MYC promotes the development of cancer remains to be fully understood. Here, we report that the Zn2+-finger transcription factor ASCIZ (ATMIN, ZNF822) synergizes with MYC to activate the expression of dynein light chain (DYNLL1, LC8) in the murine Em-Myc model of lymphoma. Deletion of Asciz or Dynll1 prevented the abnormal expansion of pre-B cells in pre-cancerous Em-Myc mice and potentiated the pro-apoptotic activity of MYC in pre-leukemic immature B cells. Constitutive loss of Asciz or Dynll1 delayed lymphoma development in Em-Myc mice, and induced deletion of Asciz in established lymphomas extended the survival of tumor-bearing mice. We propose that ASCIZ-dependent upregulation of DYNLL1 levels is essential for the development and expansion of MYC-driven lymphomas by enabling the survival of pre-neoplastic and malignant cells. |
| URI: | https://publications.svi.edu.au/publications/2000 |
| Other Identifiers | 10.1016/j.celrep.2016.01.012 |
| Publication type | Article |
| Grant ID | GNT1022469; GNT1026125 |