Title: The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma
Authors: Wong, DM
Li, LL
Jurado, S
King, A
Bamford, R
Wall, M
Walia, MK
Kelly, GL
Walkley, CR
Tarlinton, DM
Strasser, A
Heierhorst, J
Issue Year: 2016
Publisher CELL PRESS
Series Cell Reports:
Abstract How MYC promotes the development of cancer remains to be fully understood. Here, we report that the Zn2+-finger transcription factor ASCIZ (ATMIN, ZNF822) synergizes with MYC to activate the expression of dynein light chain (DYNLL1, LC8) in the murine Em-Myc model of lymphoma. Deletion of Asciz or Dynll1 prevented the abnormal expansion of pre-B cells in pre-cancerous Em-Myc mice and potentiated the pro-apoptotic activity of MYC in pre-leukemic immature B cells. Constitutive loss of Asciz or Dynll1 delayed lymphoma development in Em-Myc mice, and induced deletion of Asciz in established lymphomas extended the survival of tumor-bearing mice. We propose that ASCIZ-dependent upregulation of DYNLL1 levels is essential for the development and expansion of MYC-driven lymphomas by enabling the survival of pre-neoplastic and malignant cells.
URI: https://publications.svi.edu.au/publications/2000
Other Identifiers 10.1016/j.celrep.2016.01.012
Publication type Article
Grant ID GNT1022469; GNT1026125