Title: Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction
Authors: Kompa, AR
Greening, DW
Kong, AM
McMillan, PJ
Fang, HY
Saxena, R
Wong, RCB
Lees, JG
Sivakumaran, P
Newcomb, AE
Tannous, BA
Kos, C
Mariana, L
Loudovaris, T
Hausenloy, DJ
Lim, SY
Issue Year: 2021
Publisher OXFORD UNIV PRESS
Series CARDIOVASCULAR RESEARCH:
Abstract Purpose To report the clinical and radiological outcomes after medial femoral trochlear (MFT) osteochondral graft for the salvage of proximal scaphoid fractures with a minimum 2-year follow-up. Methods A retrospective review was performed of patients with comminuted fractures of the proximal scaphoid treated by excision of the proximal pole and replacement with free vascularized MFT osteochondral graft. Demographic data, objective and radiographic measurements, and patient-reported outcome measures of the upper limb and knee were collected. Pain was assessed by completion of a visual analog scale (VAS). Results Between February 2014 and May 2015, 12 MFT osteochondral grafts were performed. Eight patients were available for follow-up at a mean of 34 months (range, 28-39 months). The mean range of wrist flexion was 31 degrees (range, 15 degrees-60 degrees), extension was 34 degrees (range, 5 degrees-60 degrees), radial deviation was 9 degrees (range, 0 degrees-20 degrees), ulnar deviation was 28 degrees (range, 10 degrees-45 degrees) and grip strength was 42 kg (range, 25-53 kg). The median wrist pain, as measured by VAS, was 0.7 (mean, 1.3; range, 0-6). The average follow-up scapholunate, radiolunate, and radioscaphoid angles were 58.9 degrees (range, 44 degrees-93 degrees), 12.9 degrees (range, 0 degrees-30 degrees), and 46.0 degrees (range, 35 degrees-63 degrees), respectively. The mean Disabilities of the Arm, Shoulder, and Hand (DASH) score was 13.9 (range, 3-43) and Patient Rated Wrist Evaluation (PRWE) score was 22.4 (range, 2-68). The mean postoperative Oxford Knee Score was 42 (range, 14-48). One patient suffered notable knee pain at 37-month follow-up. One patient suffered notable pain on the radial side of the wrist and underwent scaphoid excision and 4-comer arthrodesis. Conclusions Replacement of the fragmented proximal scaphoid by MFT graft is an alternative to other salvage options and most patients can expect pain relief and acceptable wrist motion. These results need to be balanced against the potential for donor-site morbidity. Copyright (C) 2021 by the American Society for Surgery of the Hand. All rights reserved.
URI: https://publications.svi.edu.au/publications/6880
Other Identifiers 10.1093/cvr/cvaa088
Publication type Article